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Biology and Biochemistry

D-Index
56
Citations
10370
World Ranking
14512
National Ranking
6099

Overview

Chad A. Brautigam is a researcher affiliated with The University of Texas Southwestern Medical Center in the United States. Their work primarily falls within the broad field of Biochemistry, Genetics, and Molecular Biology, focusing on several subfields including Molecular Biology, Computational Mechanics, Physiology, Physical and Theoretical Chemistry, and Oncology.

The research topics addressed by Brautigam include:

  • RNA Research and Splicing
  • Thermodynamics and Calorimetric Analyses
  • Nuclear Structure and Function
  • Field-Flow Fractionation Techniques
  • Syphilis Diagnosis and Treatment
  • HIV Research and Treatment
  • Microfluidic and Bio-sensing Technologies

Among their recent published papers are:

  • Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X), 2021, Scientific Reports
  • Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation, 2020, Molecular Biology of the Cell
  • Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study, 2021, European Biophysics Journal
  • A multi-laboratory benchmark study of isothermal titration calorimetry (ITC) using Ca2+ and Mg2+ binding to EDTA, 2021, European Biophysics Journal
  • Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase, 2020, Cell Reports

Brautigam has collaborated frequently with a number of co-authors in their research endeavors. These collaborators include Shih-Chia Tso, Ranjit K. Deka, Wei Z. Liu, Yuh Min Chook, and Shih-Chia Tso, with multiple joint publications each.

The venues where Brautigam's work is most commonly published are:

  • European Biophysics Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS ONE
  • Molecular Biology of the Cell
  • Nature Cell Biology

Best Publications

  • Structural and functional insights provided by crystal structures of DNA polymerases and their substrate complexes

    Chad A Brautigam;Thomas A Steitz

  • The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop.

    Xu Zhang;Jiaxi Wu;Fenghe Du;Hui Xu

  • Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

    Xiaomo Jiang;Lisa N. Kinch;Chad A. Brautigam;Xiang Chen

  • Structure of the photolyase-like domain of cryptochrome 1 from Arabidopsis thaliana.

    Chad A. Brautigam;Barbara S. Smith;Zhiquan Ma;Maya Palnitkar

  • Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions

    Chad A Brautigam;Huaying Zhao;Carolyn Vargas;Sandro Keller

  • Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

    Juan L. Mendoza;André Schmidt;Qin Li;Emmanuel Nuvaga

  • A TOG:αβ-Tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

    Pelin Ayaz;Xuecheng Ye;Patrick Huddleston;Chad A. Brautigam

  • Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.

    Chad A Brautigam;Thomas A Steitz

  • Hierarchical regulation of WASP/WAVE proteins.

    Shae B. Padrick;Hui Chun Cheng;Ayman M. Ismail;Sanjay C. Panchal

  • Arp2/3 complex is bound and activated by two WASP proteins

    Shae B. Padrick;Lynda K. Doolittle;Chad A. Brautigam;David S. King

  • Side chain and backbone contributions of Phe508 to CFTR folding.

    Patrick H Thibodeau;Chad A Brautigam;Mischa Machius;Philip J Thomas

  • Structural basis of histone demethylation by LSD1 revealed by suicide inactivation

    Maojun Yang;Jeffrey C Culhane;Lawrence M Szewczuk;Christian B Gocke

  • Overview of current methods in sedimentation velocity and sedimentation equilibrium analytical ultracentrifugation.

    Huaying Zhao;Chad A. Brautigam;Rodolfo Ghirlando;Peter Schuck

  • On the acquisition and analysis of microscale thermophoresis data.

    Thomas H. Scheuermann;Shae B. Padrick;Kevin H. Gardner;Chad A. Brautigam

  • Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites

    Baoyu Chen;Hui Ting Chou;Chad A Brautigam;Wenmin Xing

  • Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

    Jie Yin;Kerim Babaoglu;Chad A Brautigam;Lindsay Clark

  • Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.

    Chad A. Brautigam;Jacinta L. Chuang;Diana R. Tomchick;Mischa Machius

  • SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

    Sung Jun Bae;Lisheng Ni;Adam Osinski;Diana R Tomchick

  • Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex.

    Chad A. Brautigam;R. Max Wynn;Jacinta L. Chuang;Mischa Machius

  • A tethered delivery mechanism explains the catalytic action of a microtubule polymerase.

    Pelin Ayaz;Sarah Munyoki;Elisabeth A. Geyer;Felipe Andrés Piedra

Frequent Co-Authors

Diana R. Tomchick
Diana R. Tomchick The University of Texas Southwestern Medical Center
Michael V. Norgard
Michael V. Norgard The University of Texas Southwestern Medical Center
Peter Schuck
Peter Schuck National Institutes of Health
Mischa Machius
Mischa Machius The University of Texas Southwestern Medical Center
David T. Chuang
David T. Chuang The University of Texas Southwestern Medical Center
Hongtao Yu
Hongtao Yu The University of Texas Southwestern Medical Center
Josep Rizo
Josep Rizo The University of Texas Southwestern Medical Center
Michael K. Rosen
Michael K. Rosen The University of Texas Southwestern Medical Center
Nick V. Grishin
Nick V. Grishin The University of Texas Southwestern Medical Center
Rodolfo Ghirlando
Rodolfo Ghirlando National Institutes of Health

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