What is he best known for?
The fields of study he is best known for:
Zhijian J. Chen mostly deals with Cell biology, Signal transduction, Biochemistry, Cyclic GMP-AMP synthase and Innate immune system.
His Cell biology research is multidisciplinary, relying on both Ubiquitin and Transcription factor.
His Ubiquitin study combines topics in areas such as Molecular biology, CHUK, Phosphorylation and Proteasome.
His studies deal with areas such as Kinase and Viral replication as well as Signal transduction.
The various areas that Zhijian J. Chen examines in his Cyclic GMP-AMP synthase study include Nucleic acid and DNA.
His Innate immune system study integrates concerns from other disciplines, such as Immunity and Virology.
His most cited work include:
- Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 (2342 citations)
- Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway (1920 citations)
- TAK1 is a ubiquitin-dependent kinase of MKK and IKK (1716 citations)
What are the main themes of his work throughout his whole career to date?
Zhijian J. Chen mainly focuses on Cell biology, Innate immune system, Ubiquitin, Signal transduction and Ubiquitin ligase.
Zhijian J. Chen has included themes like RNA and Transcription factor in his Cell biology study.
His research integrates issues of Immunity and Virology in his study of Innate immune system.
Zhijian J. Chen works mostly in the field of Ubiquitin, limiting it down to topics relating to Molecular biology and, in certain cases, DNA.
He studied Signal transduction and Apoptosis that intersect with Mitochondrion.
His study in Ubiquitin ligase is interdisciplinary in nature, drawing from both Transport protein and HEK 293 cells.
He most often published in these fields:
- Cell biology (52.73%)
- Innate immune system (30.00%)
- Ubiquitin (27.73%)
What were the highlights of his more recent work (between 2016-2021)?
- Cell biology (52.73%)
- Innate immune system (30.00%)
- Sting (7.73%)
In recent papers he was focusing on the following fields of study:
Zhijian J. Chen mainly investigates Cell biology, Innate immune system, Sting, Signal transduction and Stimulator of interferon genes.
His Cell biology study incorporates themes from Interferon, Transcription factor and Immunity.
His research in Innate immune system intersects with topics in DNA damage, DNA, Senescence and Second messenger system.
Signal transduction is a subfield of Biochemistry that Zhijian J. Chen investigates.
Zhijian J. Chen combines subjects such as Autophagy, Cancer research, Conformational change and Immunotherapy with his study of Stimulator of interferon genes.
His Phosphorylation research incorporates themes from Protein subunit, Molecular biology, RNA interference, Protein kinase domain and Binding site.
Between 2016 and 2021, his most popular works were:
- The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. (339 citations)
- The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. (339 citations)
- cGAS is essential for cellular senescence (329 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Cell biology, Innate immune system, Stimulator of interferon genes, Signal transduction and Sting.
The concepts of his Cell biology study are interwoven with issues in Molecular biology, RNA interference, Immunity and IRF3.
His research in Immunity tackles topics such as Intracellular which are related to areas like Immunology.
His work carried out in the field of Innate immune system brings together such families of science as RNA, Senescence and DNA, DNA damage.
The Stimulator of interferon genes study combines topics in areas such as Cytoplasm, Antigen, Melanoma, Growth inhibition and Immunotherapy.
His Signal transduction research is multidisciplinary, incorporating elements of Autophagy and Plasma protein binding.
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