Zhijian J. Chen

Research.com Recognitions

• 2014 - Member of the National Academy of Sciences
• 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

  Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  10661
  Citations

• Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway

  Lijun Sun;Jiaxi Wu;Fenghe Du;Xiang Chen

  4271
  Citations

• Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

  Rashu B. Seth;Lijun Sun;Chee Kwee Ea;Zhijian J. Chen

  3762
  Citations

• TAK1 is a ubiquitin-dependent kinase of MKK and IKK

  Chen Wang;Li Deng;Mei Hong;Giridhar R. Akkaraju

  2633
  Citations

• Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

  Li Deng;Chen Wang;Erika Spencer;Liyong Yang

  2370
  Citations

• Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

  Jiaxi Wu;Lijun Sun;Xiang Chen;Fenghe Du

  2272
  Citations

• STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

  Liufu Deng;Hua Liang;Meng Xu;Xuanming Yang

  2090
  Citations

• TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

  Michaela U. Gack;Young C. Shin;Chul Hyun Joo;Chul Hyun Joo;Tomohiko Urano;Tomohiko Urano

  1968
  Citations

• Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

  Qi Chen;Lijun Sun;Zhijian J Chen

  1760
  Citations

• Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

  Zhijian Chen;J. Hagler;V. J. Palombella;F. Melandri

  1732
  Citations

• Ubiquitin signalling in the NF-κB pathway

  Zhijian J. Chen

  1632
  Citations

• Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

  Siqi Liu;Xin Cai;Jiaxi Wu;Qian Cong

  1618
  Citations

• The DNA sequence of the human X chromosome

  Mark T Ross;Darren V Grafham;Alison J Coffey;Steven Scherer

  1405
  Citations

• RNA Polymerase III Detects Cytosolic DNA and Induces Type-I Interferons Through the RIG-I Pathway

  Yu Hsin Chiu;John B. MacMillan;Zhijian J. Chen

  1383
  Citations

• STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

  Yasuo Tanaka;Zhijian J. Chen

  1377
  Citations

• MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

  Fajian Hou;Lijun Sun;Hui Zheng;Brian Skaug

  1319
  Citations

• Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

  Zhijian J Chen;Lana Parent;Tom Maniatis

  1310
  Citations

• Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

  Jiaxi Wu;Zhijian J. Chen

  1209
  Citations

• Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

  Chee Kwee Ea;Li Deng;Zong Ping Xia;Gabriel Pineda

  1201
  Citations

• Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

  Xiao Dong Li;Jiaxi Wu;Daxing Gao;Hua Wang

  1092
  Citations