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Zhijian J. Chen

D-Index & Metrics

Biology and Biochemistry

D-Index
121
Citations
101858
World Ranking
594
National Ranking
379

Zhijian J. Chen publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Zhijian J. Chen sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 244 publications — 65th percentile

65% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Zhijian J. Chen D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Zhijian J. Chen sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 121 D-Index — 97th percentile

97% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2014 - Member of the National Academy of Sciences
  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Zhijian J. Chen is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research encompasses a broad range of topics within biochemistry, genetics, molecular biology, immunology, microbiology, and medicine. The scientist's work focuses significantly on molecular biology and immunology subfields, with notable contributions related to infectious diseases, oncology, and cancer research.

Their main research topics include:

  • Interferon and immune responses
  • Viral infections and vectors
  • Inflammasome and immune disorders
  • RNA modifications and cancer
  • Cancer immunotherapy and biomarkers
  • Immune cells in cancer
  • Immune response and inflammation

Zhijian J. Chen has published extensively in several scientific venues, with multiple papers appearing in:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Cancer Immunology Research
  • Science Advances

Some of the recent papers authored by Zhijian J. Chen include:

  • "Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway," 2020, Immunity
  • "TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections," 2021, Proceedings of the National Academy of Sciences
  • "Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression," 2021, Science Advances
  • "MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway," 2020, Cancer Cell
  • "Phosphorylation and chromatin tethering prevent cGAS activation during mitosis," 2021, Science

The scientist has collaborated frequently with several co-authors, including:

  • Tuo Li
  • Yan Fang
  • Mingjian Du
  • Seoyun Yum
  • Minghao Li

Zhijian J. Chen has been recognized by their peers with memberships and fellowships such as:

  • Member of the National Academy of Sciences (2014)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2012)

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway

    Lijun Sun;Jiaxi Wu;Fenghe Du;Xiang Chen

  • Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

    Rashu B. Seth;Lijun Sun;Chee Kwee Ea;Zhijian J. Chen

  • TAK1 is a ubiquitin-dependent kinase of MKK and IKK

    Chen Wang;Li Deng;Mei Hong;Giridhar R. Akkaraju

  • Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

    Li Deng;Chen Wang;Erika Spencer;Liyong Yang

  • Cyclic-GMP-AMP Is An Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

    Jiaxi Wu;Lijun Sun;Xiang Chen;Fenghe Du

  • STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

    Liufu Deng;Hua Liang;Meng Xu;Xuanming Yang

  • TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

    Michaela U. Gack;Young C. Shin;Chul Hyun Joo;Chul Hyun Joo;Tomohiko Urano;Tomohiko Urano

  • Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing

    Qi Chen;Lijun Sun;Zhijian J Chen

  • Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

    Zhijian Chen;J. Hagler;V. J. Palombella;F. Melandri

  • Ubiquitin signalling in the NF-κB pathway

    Zhijian J. Chen

  • Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

    Siqi Liu;Xin Cai;Jiaxi Wu;Qian Cong

  • The DNA sequence of the human X chromosome

    Mark T Ross;Darren V Grafham;Alison J Coffey;Steven Scherer

  • RNA Polymerase III Detects Cytosolic DNA and Induces Type-I Interferons Through the RIG-I Pathway

    Yu Hsin Chiu;John B. MacMillan;Zhijian J. Chen

  • STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.

    Yasuo Tanaka;Zhijian J. Chen

  • MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.

    Fajian Hou;Lijun Sun;Hui Zheng;Brian Skaug

  • Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

    Zhijian J Chen;Lana Parent;Tom Maniatis

  • Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

    Jiaxi Wu;Zhijian J. Chen

  • Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

    Chee Kwee Ea;Li Deng;Zong Ping Xia;Gabriel Pineda

  • Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects

    Xiao Dong Li;Jiaxi Wu;Daxing Gao;Hua Wang

Frequent Co-Authors

Ming Xu
Ming Xu University of Chicago
Tom Maniatis
Tom Maniatis Columbia University
Søren R. Paludan
Søren R. Paludan Aarhus University
Shizuo Akira
Shizuo Akira Osaka University
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Yang-Xin Fu
Yang-Xin Fu Tsinghua University
Donna M. Muzny
Donna M. Muzny Baylor College of Medicine
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine
Wei Huang
Wei Huang Northwestern Polytechnical University
Jun Wang
Jun Wang University of Central Florida

External Links

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