World's Best Scientists 2026 revealed!
Takashi Fujita

Takashi Fujita

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
56612
World Ranking
1956
National Ranking
111

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Takashi Fujita is affiliated with Kyoto University in Japan and has contributed extensively to the fields of Medicine and Immunology and Microbiology. Their research portfolio encompasses significant work in Immunology, Molecular Biology, Infectious Diseases, Cardiology and Cardiovascular Medicine, and Pulmonary and Respiratory Medicine.

Their scholarly output includes investigations primarily focused on interferon and immune responses, immune response and inflammation, viral infections and vectors, inflammasome and immune disorders, RNA regulation and disease, RNA research and splicing, and viral infections and outbreaks research.

Recent publications by Takashi Fujita include:

  • Viral RNA recognition by LGP2 and MDA5, and activation of signaling through step-by-step conformational changes (2020, Nucleic Acids Research)
  • Physiological functions of RIG-I-like receptors (2024, Immunity)
  • Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization (2020, Nucleic Acids Research)
  • Spatio-temporal characterization of the antiviral activity of the XRN1-DCP1/2 aggregation against cytoplasmic RNA viruses to prevent cell death (2020, Cell Death and Differentiation)
  • The Role of Non-Structural Protein NSs in the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome (2021, Viruses)

Takashi Fujita's frequent co-authors include:

  • Hiroki Kato
  • S. Ishida
  • Kei Yagami
  • Masato Mutsuga
  • Mitsutoshi Yoneyama

Their work has been published in several scientific journals with multiple publications in:

  • Scientific Reports
  • Nucleic Acids Research
  • Journal of Virology
  • Cell Death and Disease
  • International Immunology

Takashi Fujita's research contributes to understanding molecular and cellular mechanisms underlying immune system functions and viral pathogenesis. This includes detailed analyses of RNA recognition by cellular receptors, phosphorylation mechanisms in immune response regulation, and the role of viral proteins in disease progression.

Best Publications

  • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.

    Mitsutoshi Yoneyama;Mika Kikuchi;Takashi Natsukawa;Noriaki Shinobu

  • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

    Hiroki Kato;Osamu Takeuchi;Shintaro Sato;Mitsutoshi Yoneyama

  • Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

    Mitsutoshi Yoneyama;Mika Kikuchi;Kanae Matsumoto;Tadaatsu Imaizumi

  • Cell type-specific involvement of RIG-I in antiviral response

    Hiroki Kato;Shintaro Sato;Mitsutoshi Yoneyama;Masahiro Yamamoto

  • Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

    Hiroki Kato;Osamu Takeuchi;Eriko Mikamo-Satoh;Eriko Mikamo-Satoh;Reiko Hirai

  • A new protein containing an SH2 domain that inhibits JAK kinases

    Takaho A. Endo;Masaaki Masuhara;Masahiro Yokouchi;Ritsu Suzuki

  • Structure and expression of a cloned cDNA for human interleukin-2

    Tadatsugu Taniguchi;Hiroshi Matsui;Takashi Fujita;Chikako Takaoka

  • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.

    Taro Kawai;Osamu Takeuchi;Takashi Fujita;Jun-ichiro Inoue

  • Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

    Masahiro Yamamoto;Shintaro Sato;Hiroaki Hemmi;Hideki Sanjo

  • Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

    Masaaki Miyamoto;Takashi Fujita;Yoko Kimura;Mitsuo Maruyama

  • Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

    Hisashi Harada;Takashi Fujita;Masaaki Miyamoto;Yoko Kimura

  • Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

    Rhea Sumpter;Yueh Ming Loo;Eileen Foy;Kui Li

  • Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF‐3 and CBP/p300

    Mitsutoshi Yoneyama;Wakako Suhara;Yukiko Fukuhara;Makoto Fukuda

  • Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

    Takeshi Saito;Reiko Hirai;Yueh Ming Loo;David Owen

  • LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

    Takashi Satoh;Hiroki Kato;Yutaro Kumagai;Mitsutoshi Yoneyama

  • RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease

    Shinji Sato;Kana Hoshino;Takashi Satoh;Tomonobu Fujita

  • RNA recognition and signal transduction by RIG-I-like receptors.

    Mitsutoshi Yoneyama;Takashi Fujita

  • Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling.

    Eileen Foy;Kui Li;Rhea Sumpter;Yueh Ming Loo

  • The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.

    Sheng Cui;Katharina Eisenächer;Axel Kirchhofer;Krzysztof Brzózka

  • Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

    Kiyohiro Takahasi;Mitsutoshi Yoneyama;Mitsutoshi Yoneyama;Tatsuya Nishihori;Reiko Hirai

Frequent Co-Authors

Mitsutoshi Yoneyama
Mitsutoshi Yoneyama Chiba University
Tadatsugu Taniguchi
Tadatsugu Taniguchi University of Tokyo
Hiroji Iwata
Hiroji Iwata Aichi Cancer Center
Shizuo Akira
Shizuo Akira Osaka University
Suryaprakash Sambhara
Suryaprakash Sambhara Centers for Disease Control and Prevention
Koichi Watashi
Koichi Watashi National Institute of Infectious Diseases
Tadaatsu Imaizumi
Tadaatsu Imaizumi Hirosaki University
Fuyuhiko Inagaki
Fuyuhiko Inagaki Hokkaido University
Hisashi Harada
Hisashi Harada Virginia Commonwealth University
Osamu Takeuchi
Osamu Takeuchi Kyoto University

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