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Biology and Biochemistry

D-Index
62
Citations
32295
World Ranking
10509
National Ranking
4559

Overview

Hisashi Harada is affiliated with Virginia Commonwealth University in the United States. Their research focuses prominently on biochemistry, genetics, and molecular biology, with considerable contributions to medicine. The scientist's work spans several interconnected subfields, including molecular biology, oncology, physiology, immunology, and pathology and forensic medicine.

The research topics covered by Hisashi Harada emphasize key molecular processes and cancer biology. These include telomeres, telomerase, and senescence; ubiquitin and proteasome pathways; protein degradation and inhibitors; cancer-related molecular pathways; advanced biosensing and bioanalysis techniques; immunotherapy and immune responses; and PARP inhibition in cancer therapy.

Several recent papers exemplify the scientist's research scope and publication activity. These include:

  • Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-XL-BAX interaction (2020, Molecular Oncology)
  • FOSL1 promotes metastasis of head and neck squamous cell carcinoma through super-enhancer-driven transcription program (2021, Molecular Therapy)
  • Androgen-deprivation induced senescence in prostate cancer cells is permissive for the development of castration-resistance but susceptible to senolytic therapy (2021, Biochemical Pharmacology)
  • Senolytic-Mediated Elimination of Head and Neck Tumor Cells Induced Into Senescence by Cisplatin (2021, Molecular Pharmacology)
  • NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy (2023, Scientific Reports)

Hisashi Harada frequently publishes in specialized venues with a focus on oncology and molecular research. Venues with multiple publications include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemical Pharmacology
  • Cancers
  • International Journal of Molecular Sciences

Collaboration plays a role in their research activities, with a number of frequent co-authors contributing to shared studies. Long-term collaborators include Victoria Neely, David A. Gewirtz, Anthony C. Faber, Jennifer E. Koblinski, and Tareq Saleh.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

    Jiping Zha;Hisashi Harada;Elizabeth Yang;Jennifer Jockel

  • Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

    Toshio Hirano;Kiyoshi Yasukawa;Hisashi Harada;Tetsuya Taga

  • Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

    Masaaki Miyamoto;Takashi Fujita;Yoko Kimura;Mitsuo Maruyama

  • Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

    Hisashi Harada;Takashi Fujita;Masaaki Miyamoto;Yoko Kimura

  • Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

    R. Kamijo;H. Harada;T. Matsuyama;Maarten C. Bosland

  • Phosphorylation and Inactivation of BAD by Mitochondria-Anchored Protein Kinase A

    Hisashi Harada;Brian Becknell;Matthias Wilm;Matthias Mann

  • p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

    Hisashi Harada;Jens S. Andersen;Matthias Mann;Naohiro Terada

  • Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

    Nobuyuki Tanaka;Masahiko Ishihara;Motoo Kitagawa;Hisashi Harada

  • Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

    Hisashi Harada;Motoo Kitagawa;Nobuyuki Tanaka;Hitomi Yamamoto

  • Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia

    C L Willman;C E Sever;M G Pallavicini;H Harada

  • Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering.

    Mitsuo Maruyama;Hiroshi Shibuya;Hisashi Harada;Masanori Hatakeyama

  • Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.

    Shuang Chen;Yun Dai;Hisashi Harada;Paul Dent

  • Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

    Hisashi Harada;Keith Willison;Jun Sakakibara;Masaaki Miyamoto

  • BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity

    Jiping Zha;Hisashi Harada;Konstantin Osipov;Jennifer Jockel

  • Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

    Hisashi Harada;Bonnie Quearry;Antonio Ruiz-Vela;Stanley J. Korsmeyer

  • Involvement of the IRF-1 transcription factor in antiviral responses to interferons

    Tohru Kimura;Katsutoshi Nakayama;Josef Penninger;Motoo Kitagawa

  • Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

    H. Harada;E.-I. Takahashi;S. Itoh;K. Harada

  • Bad-deficient mice develop diffuse large B cell lymphoma

    Ann M. Ranger;Jiping Zha;Hisashi Harada;Sandeep Robert Datta

  • An Shp2/SFK/Ras/Erk Signaling Pathway Controls Trophoblast Stem Cell Survival

    Wentian Yang;Lori D. Klaman;Binbin Chen;Toshiyuki Araki

Frequent Co-Authors

Tadatsugu Taniguchi
Tadatsugu Taniguchi University of Tokyo
Norihiko Misawa
Norihiko Misawa Ishikawa Prefectural University
Steven Grant
Steven Grant Virginia Commonwealth University
Paul Dent
Paul Dent Virginia Commonwealth University
Takashi Fujita
Takashi Fujita Kyoto University
Stanley J. Korsmeyer
Stanley J. Korsmeyer Harvard University
David A. Gewirtz
David A. Gewirtz Virginia Commonwealth University
Cheryl L. Willman
Cheryl L. Willman University of New Mexico
Ray White
Ray White University of Utah
Yusuke Nakamura
Yusuke Nakamura National Institutes of Biomedical Innovation, Health and Nutrition

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