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Hiroyuki Oshiumi

Hiroyuki Oshiumi

D-Index & Metrics

Microbiology

D-Index
52
Citations
13113
World Ranking
4167
National Ranking
170

Overview

Hiroyuki Oshiumi is affiliated with Kumamoto University in Japan. Their research primarily spans the fields of biochemistry, genetics, molecular biology, immunology, microbiology, and medicine. Within these areas, Oshiumi's work frequently intersects with subfields such as immunology, molecular biology, infectious diseases, cancer research, and oncology.

Their main research topics cover a range of areas focused on immune responses and disease regulation, including:

  • interferon and immune responses
  • immunotherapy and immune responses
  • SARS-CoV-2 and COVID-19 research
  • immune response and inflammation
  • immune cells in cancer
  • extracellular vesicles in disease
  • microRNA in disease regulation

Oshiumi has contributed to scientific literature in various publication venues. Some of the most frequent outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Nature Communications
  • iScience
  • EMBO Reports

They have coauthored numerous papers with other researchers, with frequent collaborators including Takahisa Kouwaki, Hirotake Tsukamoto, Ken Takashima, Tasuku Nishimura, and Yusuke Miyashita.

Among their recent publications are the following papers:

  • "RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses," 2021, Frontiers in Immunology
  • "Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti-PD-1 therapy-induced adverse events," 2022, Proceedings of the National Academy of Sciences
  • "Supersulphides provide airway protection in viral and chronic lung diseases," 2023, Nature Communications
  • "Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly," 2020, iScience
  • "Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination," 2022, npj Vaccines

Best Publications

  • TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.

    Hiroyuki Oshiumi;Misako Matsumoto;Kenji Funami;Takashi Akazawa

  • Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells

    Misako Matsumoto;Kenji Funami;Masako Tanabe;Hiroyuki Oshiumi

  • TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β

    Hiroyuki Oshiumi;Miwa Sasai;Kyoko Shida;Takashi Fujita

  • Complex Formation and Functional Versatility of Mre11 of Budding Yeast in Recombination

    Takehiko Usui;Tsutomu Ohta;Hiroyuki Oshiumi;Hiroyuki Oshiumi;Jun-ichi Tomizawa

  • Riplet/RNF135, a RING Finger Protein, Ubiquitinates RIG-I to Promote Interferon-β Induction during the Early Phase of Viral Infection

    Hiroyuki Oshiumi;Misako Matsumoto;Shigetsugu Hatakeyama;Tsukasa Seya

  • Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.

    Aya Matsuo;Hiroyuki Oshiumi;Tadayuki Tsujita;Hiroshi Mitani

  • Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells

    Unknown

  • Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome

    Hiroyuki Oshiumi;Tadayuki Tsujita;Kyoko Shida;Misako Matsumoto

  • Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment.

    Hirotake Tsukamoto;Koji Fujieda;Azusa Miyashita;Satoshi Fukushima

  • DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling

    Moeko Miyashita;Hiroyuki Oshiumi;Misako Matsumoto;Tsukasa Seya

  • The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.

    Hiroyuki Oshiumi;Moeko Miyashita;Naokazu Inoue;Masaru Okabe

  • Sensing bacterial flagellin by membrane and soluble orthologs of toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss)

    Tadayuki Tsujita;Hironobu Tsukada;Miki Nakao;Hiroyuki Oshiumi

  • Toll-like receptor 3: a link between toll-like receptor, interferon and viruses.

    Misako Matsumoto;Kenji Funami;Hiroyuki Oshiumi;Tsukasa Seya

  • Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

    Kai Yasukawa;Hiroyuki Oshiumi;Makoto Takeda;Naotada Ishihara

  • Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

    Hiroaki Shime;Misako Matsumoto;Hiroyuki Oshiumi;Shinya Tanaka

  • DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.

    Hiroyuki Oshiumi;Keisuke Sakai;Misako Matsumoto;Tsukasa Seya

  • A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

    Hiroyuki Oshiumi;Moeko Miyashita;Misako Matsumoto;Tsukasa Seya

  • The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling

    Kenji Funami;Misako Matsumoto;Hiroyuki Oshiumi;Takashi Akazawa

  • Antiviral responses induced by the TLR3 pathway.

    Misako Matsumoto;Hiroyuki Oshiumi;Tsukasa Seya

  • DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation

    Hiroyuki Oshiumi;Moeko Miyashita;Masaaki Okamoto;Yuka Morioka

  • Collaborative Action of Brca1 and CtIP in Elimination of Covalent Modifications from Double-Strand Breaks to Facilitate Subsequent Break Repair

    Kyoko Nakamura;Toshiaki Kogame;Hiroyuki Oshiumi;Akira Shinohara

  • Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection.

    Takahisa Kouwaki;Yoshimi Fukushima;Takuji Daito;Takahiro Sanada

Frequent Co-Authors

Tsukasa Seya
Tsukasa Seya Hokkaido University
Misako Matsumoto
Misako Matsumoto Aomori University
Yasuharu Nishimura
Yasuharu Nishimura Kumamoto University
Masaru Okabe
Masaru Okabe Osaka University
Nobuyuki Kato
Nobuyuki Kato Okayama University
Fuyuhiko Inagaki
Fuyuhiko Inagaki Hokkaido University
Akira Shinohara
Akira Shinohara Osaka University
Tadaki Suzuki
Tadaki Suzuki National Institutes of Health
Michinori Kohara
Michinori Kohara Tokyo Metropolitan Institute of Medical Science
Masanori Kasahara
Masanori Kasahara Hokkaido University

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