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Søren R. Paludan

Søren R. Paludan

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Immunology
Denmark
2026

D-Index & Metrics

Immunology

D-Index
87
Citations
34789
World Ranking
1199
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Immunology in Denmark Leader Award
  • 2025 - Research.com Immunology in Denmark Leader Award

Overview

Søren R. Paludan is a researcher affiliated with Aarhus University in Denmark, focusing primarily on the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Immunology, Molecular Biology, Infectious Diseases, Epidemiology, and Neurology.

Their research emphasizes several main topics including interferon and immune responses, viral infections and vectors, herpesvirus infections and treatments, inflammasome and immune disorders, SARS-CoV-2 and COVID-19 research, cytomegalovirus and herpesvirus research, and immune response and inflammation.

Paludan has published extensively, with a significant number of works in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, The Journal of Experimental Medicine, Nature Immunology, and The EMBO Journal.

Frequent coauthors in their research include:

  • Line S. Reinert
  • Trine H. Mogensen
  • Manja Idorn
  • David Olagnier
  • Marie B. Iversen

Notable recent papers authored or coauthored by Søren R. Paludan include:

  • Constitutive immune mechanisms: mediators of host defence and immune regulation, 2020, Nature Reviews. Immunology
  • SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate, 2020, Nature Communications
  • Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice, 2021, Nature Biomedical Engineering
  • Targeting herpes simplex virus with CRISPR-Cas9 cures herpetic stromal keratitis in mice, 2021, Nature Biotechnology
  • STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses, 2022, Cell Metabolism

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • IFI16 is an innate immune sensor for intracellular DNA.

    Leonie Unterholzner;Sinead E. Keating;Marcin Baran;Kristy A. Horan

  • Double-Stranded RNA Is Produced by Positive-Strand RNA Viruses and DNA Viruses but Not in Detectable Amounts by Negative-Strand RNA Viruses

    Friedemann Weber;Valentina Wagner;Simon B. Rasmussen;Rune Hartmann

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Immune sensing of DNA

    Søren R. Paludan;Andrew G. Bowie

  • Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo

    Nina Ank;Hans West;Christina Bartholdy;Kristina Eriksson

  • Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases

    Zhangle Zhou;Ole J. Hamming;Nina Ank;Søren R. Paludan

  • Molecular Pathways in Virus-Induced Cytokine Production

    Trine H. Mogensen;Søren R. Paludan

  • An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity.

    Nina Ank;Marie B. Iversen;Christina Bartholdy;Peter Staeheli

  • Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.

    Rory R Koenen;Philipp von Hundelshausen;Irina V Nesmelova;Alma Zernecke

  • Attenuation of cGAS-STING Signaling Is Mediated by a p62/SQSTM1-dependent Autophagy Pathway Activated by TBK1

    Thaneas Prabakaran;Chiranjeevi Bodda;Chiranjeevi Bodda;Christian Krapp;Bao‐cun Zhang

  • Recognition of herpesviruses by the innate immune system

    Søren R. Paludan;Andrew G. Bowie;Kristy A. Horan;Katherine A. Fitzgerald

  • SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

    David Olagnier;Ensieh Farahani;Jacob Thyrsted;Julia Blay-Cadanet

  • Interferon-lambda contributes to innate immunity of mice against influenza A virus but not against hepatotropic viruses

    Markus Mordstein;Georg Kochs;Laure Dumoutier;Jean-Christophe Renauld

  • Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS

    Line S Reinert;Katarína Lopušná;Katarína Lopušná;Henriette Winther;Chenglong Sun

  • IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

    Martin R. Jakobsen;Rasmus O. Bak;Annika Andersen;Randi K. Berg;Randi K. Berg

  • Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

    Kenneth A Howard;Søren R Paludan;Mark A Behlke;Flemming Besenbacher

  • Constitutive immune mechanisms: mediators of host defence and immune regulation

    Søren R. Paludan;Søren R. Paludan;Thomas Pradeu;Seth L. Masters;Seth L. Masters;Trine H. Mogensen;Trine H. Mogensen

  • IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

    K L Jønsson;A Laustsen;C Krapp;C Krapp;K A Skipper

  • IFN-λ: Novel Antiviral Cytokines

    Nina Ank;Hans West;Søren R Paludan

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

Frequent Co-Authors

Trine H. Mogensen
Trine H. Mogensen Aarhus University
Lars Østergaard
Lars Østergaard Aarhus University Hospital
Rune Hartmann
Rune Hartmann Aarhus University
Andrew G. Bowie
Andrew G. Bowie Trinity College Dublin
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Sampsa Matikainen
Sampsa Matikainen University of Helsinki
Allan Randrup Thomsen
Allan Randrup Thomsen University of Copenhagen
Zhijian J. Chen
Zhijian J. Chen The University of Texas Southwestern Medical Center
Lars Iversen
Lars Iversen Aarhus University Hospital
Trairak Pisitkun
Trairak Pisitkun Chulalongkorn University

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