World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
18958
World Ranking
3589
National Ranking
1793

Overview

Rodolfo Ghirlando is affiliated with the National Institutes of Health in the United States. Their research is primarily situated within the field of Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Infectious Diseases, Computational Theory and Mathematics, Genetics, and Cell Biology as subfields.

Their research topics include RNA and protein synthesis mechanisms, protein structure and dynamics, computational drug discovery methods, SARS-CoV-2 and COVID-19 research, enzyme structure and function, RNA research and splicing, and CRISPR and genetic engineering.

Rodolfo Ghirlando has published extensively, with notable papers including:

  • Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms, 2020, Molecular Cell
  • Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor, 2022, Communications Biology
  • Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease, 2020, Proceedings of the National Academy of Sciences
  • HIV-1 matrix-tRNA complex structure reveals basis for host control of Gag localization, 2021, Cell Host & Microbe
  • Transient lipid-bound states of spike protein heptad repeats provide insights into SARS-CoV-2 membrane fusion, 2021, Science Advances

Frequent co-authors in Rodolfo Ghirlando's work include John M. Louis, Nashaat T. Nashed, Annie Aniana, Andrey Kovalevsky, and Leighton Coates. These collaborations reflect interdisciplinary efforts across multiple studies and research areas.

Their publications are regularly featured in several scientific venues, with concentrations in Communications Biology, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Proceedings of the National Academy of Sciences, and the Journal of Molecular Biology.

Best Publications

  • Mode of formation and structural features of DNA-cationic liposome complexes used for transfection.

    Hezi Gershon;Rodolfo Ghirlando;Susan B. Guttman;Abraham Minsky

  • Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex: A Role for Scaffolding in Enzyme Regulation

    Tomas Obsil;Rodolfo Ghirlando;David C Klein;Surajit Ganguly

  • Atomic-resolution dynamics on the surface of amyloid-β protofibrils probed by solution NMR

    Nicolas L. Fawzi;Jinfa Ying;Rodolfo Ghirlando;Dennis A. Torchia

  • The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms.

    Y Mimura;S Church;R Ghirlando;P.R Ashton

  • A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

    Hidenori Kato;Jiansheng Jiang;Bing Rui Zhou;Marieke Rozendaal

  • A Soluble Active Mutant of HIV-1 Integrase INVOLVEMENT OF BOTH THE CORE AND CARBOXYL-TERMINAL DOMAINS IN MULTIMERIZATION

    Timothy M. Jenkins;Alan Engelman;Rodolfo Ghirlando;Robert Craigie

  • Role of Oligosaccharide Residues of IgG1-Fc in FcγRIIb Binding

    Yusuke Mimura;Peter Sondermann;Rodolfo Ghirlando;John Lund

  • Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription

    Marcin Nowotny;Sergei A. Gaidamakov;Rodolfo Ghirlando;Susana M. Cerritelli

  • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

    Bettina M. Lengsfeld;Alison J. Rattray;Venugopal Bhaskara;Rodolfo Ghirlando

  • The TLR3 signaling complex forms by cooperative receptor dimerization

    Joshua N. Leonard;Rodolfo Ghirlando;Janine Askins;Jessica K. Bell

  • Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex

    Ronglan Zheng;Rodolfo Ghirlando;Myung Soo Lee;Kiyoshi Mizuuchi

  • CTCF: making the right connections.

    Rodolfo Ghirlando;Gary Felsenfeld

  • Mechanism of ubiquitin recognition by the CUE domain of Vps9p.

    Gali Prag;Saurav Misra;Eudora A. Jones;Rodolfo Ghirlando

  • Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55

    Hyung Ho Lee;Natalie Elia;Rodolfo Ghirlando;Jennifer Lippincott-Schwartz

  • Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA.

    Mengli Cai;Ying Huang;Rodolfo Ghirlando;Katherine L. Wilson

  • Structural Mechanisms of Nucleosome Recognition by Linker Histones.

    Bing Rui Zhou;Jiansheng Jiang;Hanqiao Feng;Rodolfo Ghirlando

  • Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues

    Timothy A. Schulz;Mal Gi Choi;Sumana Raychaudhuri;Jason A. Mears

  • Crystal structure of the Xrcc4 DNA repair protein and implications for end joining.

    Murray S. Junop;Mauro Modesti;Alba Guarné;Rodolfo Ghirlando

  • Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues.

    Timothy M. Jenkins;Alison B. Hickman;Fred Dyda;Rodolfo Ghirlando

  • Molecular Architecture and Functional Model of the Complete Yeast ESCRT-I Heterotetramer

    Michael S. Kostelansky;Cayetana Schluter;Yuen Yi C. Tam;Sangho Lee

Frequent Co-Authors

G. Marius Clore
G. Marius Clore National Institutes of Health
Peter Schuck
Peter Schuck National Institutes of Health
Gary Felsenfeld
Gary Felsenfeld National Institutes of Health
John M. Louis
John M. Louis National Institutes of Health
Robert Craigie
Robert Craigie National Institutes of Health
Carole A. Bewley
Carole A. Bewley National Institutes of Health
Fred Dyda
Fred Dyda National Institutes of Health
Hannah J. Gould
Hannah J. Gould King's College London
Frank McCormick
Frank McCormick University of California, San Francisco
Chad A. Brautigam
Chad A. Brautigam The University of Texas Southwestern Medical Center

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