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D-Index & Metrics

Molecular Biology

D-Index
66
Citations
19962
World Ranking
1607
National Ranking
814

Overview

Robert Craigie is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. Their work spans significant topics including HIV research and treatment, HIV/AIDS drug development and treatment, biochemical and molecular research, and related health complications and treatments.

Their published research includes studies on the molecular mechanisms of HIV integration and resistance to antiretroviral drugs. Notable recent papers include:

  • Structural basis for strand-transfer inhibitor binding to HIV intasomes, 2020, Science
  • Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants, 2023, Science Advances
  • HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA, 2022, Journal of Virology
  • A Peptide Derived from Lens Epithelium-Derived Growth Factor Stimulates HIV-1 DNA Integration and Facilitates Intasome Structural Studies, 2020, Journal of Molecular Biology
  • Human Three Prime Repair Exonuclease 1 Promotes HIV-1 Integration by Preferentially Degrading Unprocessed Viral DNA, 2021, Journal of Virology

Frequent co-authors in their work include Dmitry Lyumkis, Avik Biswas, Steven J. Smith, Terrence R. Burke, and Indrani Choudhuri. These collaborations have contributed to a range of studies primarily focused on the mechanisms of HIV infection and molecular biology of viral integration.

The scientist's work has been published frequently in journals such as Biophysical Journal, bioRxiv (Cold Spring Harbor Laboratory), Journal of Virology, Journal of Molecular Biology, and Science. This demonstrates a breadth of engagement with both preprint and peer-reviewed scientific communication platforms.

Their main fields of study encompass medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. The subfields they focus on include virology, infectious diseases, molecular biology, emergency medicine, and epidemiology.

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

  • Virology
  • Infectious Diseases
  • Molecular Biology
  • Emergency Medicine
  • Epidemiology

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Biochemical and Molecular Research
  • HIV-related health complications and treatments
  • Genomics and Chromatin Dynamics
  • RNA Interference and Gene Delivery
  • Cytomegalovirus and herpesvirus research

Best Publications

  • Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.

    Fred Dyda;Alison B. Hickman;Timothy M. Jenkins;Alan Engelman

  • HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer

    Alan Engelman;Kiyoshi Mizuuchi;Robert Craigie

  • Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design

    Yehuda Goldgur;Robert Craigie;Gerson H. Cohen;Tamio Fujiwara

  • Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.

    A Engelman;R Craigie

  • Activities of Human Immunodeficiency Virus (HIV) Integration Protein In vitro: Specific Cleavage and Integration of HIV DNA

    Frederic D. Bushman;Robert Craigie

  • Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.

    A Engelman;G Englund;J M Orenstein;M A Martin

  • The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro

    Robert Craigie;Tamio Fujiwara;Frederic Bushman

  • Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.

    Yehuda Goldgur;Fred Dyda;Alison B. Hickman;Timothy M. Jenkins

  • HIV DNA Integration

    Robert Craigie;Frederic D. Bushman

  • Retroviral DNA integration directed by HIV integration protein in vitro.

    Frederic D. Bushman;Tamio Fujiwara;Robert Craigie

  • Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

    Ronglan Zheng;Timothy M. Jenkins;Robert Craigie

  • Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding.

    Frederic D. Bushman;Alan Engelman;Ira Palmer;Paul Wingfield

  • Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.

    A Engelman;F D Bushman;R Craigie

  • Solution structure of the N-terminal zinc binding domain of HIV-1 integrase.

    M Cai;R Zheng;M Caffrey;R Craigie

  • Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.

    Jian-Yong Wang;Hong Ling;Wei Yang;Robert Craigie

  • The road to chromatin - nuclear entry of retroviruses.

    Youichi Suzuki;Robert Craigie

  • HIV Integrase, a Brief Overview from Chemistry to Therapeutics

    Robert Craigie

  • Solution structure of the DNA binding domain of HIV-1 integrase.

    P.J Lodi;J.A Ernst;J Kuszewski;A.B Hickman

  • A Soluble Active Mutant of HIV-1 Integrase INVOLVEMENT OF BOTH THE CORE AND CARBOXYL-TERMINAL DOMAINS IN MULTIMERIZATION

    Timothy M. Jenkins;Alan Engelman;Rodolfo Ghirlando;Robert Craigie

  • A Previously Unidentified Host Protein Protects Retroviral DNA from Autointegration

    Myung Soo Lee;Robert Craigie

Frequent Co-Authors

Alan Engelman
Alan Engelman Harvard University
Kiyoshi Mizuuchi
Kiyoshi Mizuuchi National Institutes of Health
Frederic D. Bushman
Frederic D. Bushman University of Pennsylvania
G. Marius Clore
G. Marius Clore National Institutes of Health
Rodolfo Ghirlando
Rodolfo Ghirlando National Institutes of Health
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
David R. Davies
David R. Davies National Institutes of Health
Mamuka Kvaratskhelia
Mamuka Kvaratskhelia University of Colorado Denver
Katherine L. Wilson
Katherine L. Wilson Johns Hopkins University School of Medicine
Fred Dyda
Fred Dyda National Institutes of Health

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