His main research concerns Integrase, DNA, DNA Integration, Protein structure and Stereochemistry. His Integrase study combines topics in areas such as Active site, Binding site and Host chromosome. His research in DNA is mostly focused on DNA Nucleotidyltransferases.
His biological study spans a wide range of topics, including Enzyme and Protein folding. His study in Stereochemistry is interdisciplinary in nature, drawing from both Crystallography and Helix. As part of one scientific family, he deals mainly with the area of DNA ligase, narrowing it down to issues related to the Molecular biology, and often Viral entry.
His primary areas of investigation include Integrase, DNA, Molecular biology, Virus Integration and Cell biology. His Integrase research is multidisciplinary, relying on both Protein structure, DNA Integration and Virology. His studies deal with areas such as Enzyme, Stereochemistry, Binding site and Protein folding as well as Protein structure.
His research in DNA intersects with topics in Biophysics, Reverse transcriptase and Viral replication. The study incorporates disciplines such as Base pair and DNA ligase in addition to Molecular biology. Robert Craigie combines subjects such as Retrovirus, DNA Nucleotidyltransferases and Host chromosome with his study of Virus Integration.
His primary scientific interests are in Integrase, DNA, Nucleoprotein, Retrovirus and Cell biology. The concepts of his Integrase study are interwoven with issues in DNA Integration, Computational biology and Virology. His studies in DNA integrate themes in fields like Virus, Viral replication and Stereochemistry.
The Nucleoprotein study combines topics in areas such as Chromatin, Strand transfer and Spumavirus. His work carried out in the field of Retrovirus brings together such families of science as Virus Integration and Biophysics. His Cell biology study frequently draws parallels with other fields, such as Molecular biology.
The scientist’s investigation covers issues in Integrase, Retrovirus, DNA, Cell biology and HIV integration. His Retrovirus research is multidisciplinary, incorporating elements of Virus Integration and DNA Integration. His DNA Integration study incorporates themes from Biochemical mechanism, Cellular dna and Enzyme.
Robert Craigie studies Nucleoprotein, a branch of DNA. Robert Craigie studied Cell biology and Chromatin that intersect with Nuclear membrane. Robert Craigie combines subjects such as Reverse transcriptase and Computational biology with his study of Genetics.
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Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases.
Fred Dyda;Alison B. Hickman;Timothy M. Jenkins;Alan Engelman.
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
Alan Engelman;Kiyoshi Mizuuchi;Robert Craigie.
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro.
A Engelman;R Craigie.
Journal of Virology (1992)
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design
Yehuda Goldgur;Robert Craigie;Gerson H. Cohen;Tamio Fujiwara.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
A Engelman;G Englund;J M Orenstein;M A Martin.
Journal of Virology (1995)
The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro
Robert Craigie;Tamio Fujiwara;Frederic Bushman.
Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium.
Yehuda Goldgur;Fred Dyda;Alison B. Hickman;Timothy M. Jenkins.
Proceedings of the National Academy of Sciences of the United States of America (1998)
Activities of Human Immunodeficiency Virus (HIV) Integration Protein In vitro: Specific Cleavage and Integration of HIV DNA
Frederic D. Bushman;Robert Craigie.
Proceedings of the National Academy of Sciences of the United States of America (1991)
Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex.
A Engelman;F D Bushman;R Craigie.
The EMBO Journal (1993)
Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding.
Frederic D. Bushman;Alan Engelman;Ira Palmer;Paul Wingfield.
Proceedings of the National Academy of Sciences of the United States of America (1993)
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