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Biology and Biochemistry

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Overview

Peter Cherepanov is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily focuses on Medicine, with significant contributions in Biochemistry, Genetics and Molecular Biology. The scientist's work spans several subfields including Infectious Diseases, Molecular Biology, Virology, Immunology, and Animal Science and Zoology.

Their body of research covers key topics mostly related to viral infections and immunology, with a strong emphasis on SARS-CoV-2 and COVID-19. Specific topics addressed in their work include:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • HIV Research and Treatment
  • Animal Virus Infections Studies
  • Long-Term Effects of COVID-19
  • HIV/AIDS drug development and treatment

Recent publications by Peter Cherepanov include:

  • Preexisting and de novo humoral immunity to SARS-CoV-2 in humans, 2020, Science
  • The effect of spike mutations on SARS-CoV-2 neutralization, 2021, Cell Reports
  • Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers, 2020, The Lancet
  • Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination, 2021, PLoS Pathogens
  • Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant, 2021, Immunity

They have collaborated frequently with a number of coauthors including Annachiara Rosa, Laura E. McCoy, Chloë Roustan, Eleni Nastouli, and Judith Heaney. These collaborations underscore a broad network within infectious disease and molecular biology research communities.

Their research is commonly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • mBio
  • Science
  • Cell Reports

Best Publications

  • Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

    Kevin W. Ng;Nikhil Faulkner;Georgina H. Cornish;Annachiara Rosa

  • HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

    Peter Cherepanov;Goedele Maertens;Paul Proost;Bart Devreese

  • Retroviral intasome assembly and inhibition of DNA strand transfer

    Stephen Hare;Saumya Shree Gupta;Saumya Shree Gupta;Eugene Valkov;Eugene Valkov;Alan N Engelman

  • LEDGF/p75 Is Essential for Nuclear and Chromosomal Targeting of HIV-1 Integrase in Human Cells

    Goedele Maertens;Peter Cherepanov;Willem Pluymers;Katrien Busschots

  • The structural biology of HIV-1: mechanistic and therapeutic insights.

    Alan Engelman;Peter Cherepanov

  • LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

    Ming-Chieh Shun;Nidhanapati K. Raghavendra;Nick Vandegraaff;Janet E. Daigle

  • Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

    Peter Cherepanov;Andre L. B. Ambrosio;Shaila Rahman;Tom Ellenberger

  • Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector.

    B. Joseph Hinnebusch;Amy E. Rudolph;Peter Cherepanov;Jack E. Dixon

  • Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.

    Stephen Hare;Ann M. Vos;Reginald F. Clayton;Jan W. Thuring

  • The mechanism of retroviral integration from X-ray structures of its key intermediates

    Goedele N Maertens;Stephen Hare;Peter Cherepanov Cherepanov

  • Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

    Peter Cherepanov;Eric Devroe;Pamela A. Silver;Alan Engelman

  • The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication

    Alan N. Engelman;Peter Cherepanov

  • Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).

    Stephen Hare;Steven J. Smith;Mathieu Métifiot;Albert Jaxa-Chamiec

  • Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75.

    Peter Cherepanov;Zhen-Yu J Sun;Shaila Rahman;Goedele Maertens

  • Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers.

    Catherine F Houlihan;Nina Vora;Thomas Byrne;Dan Lewer

  • Retroviral DNA Integration

    Paul Lesbats;Alan N. Engelman;Peter Cherepanov;Peter Cherepanov

  • The effect of spike mutations on SARS-CoV-2 neutralization.

    Chloe Rees-Spear;Luke Muir;Sarah A. Griffith;Judith Heaney

  • Structure-based modeling of the functional HIV-1 intasome and its inhibition

    Lavanya Krishnan;Xiang Li;Hema L. Naraharisetty;Stephen Hare

  • Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

    Kevin Ng;Nikhil Faulkner;Georgina Cornish;Annachiara Rosa

  • Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

    Stephen Hare;Steven J. Smith;Albert Jaxa-Chamiec;Yves Pommier

Frequent Co-Authors

Alan Engelman
Alan Engelman Harvard University
Zeger Debyser
Zeger Debyser KU Leuven
George Kassiotis
George Kassiotis The Francis Crick Institute
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Charles Swanton
Charles Swanton The Francis Crick Institute
Mike Hubank
Mike Hubank Royal Marsden NHS Foundation Trust
Rogier W. Sanders
Rogier W. Sanders University of Amsterdam
Stephen Hughes
Stephen Hughes National Cancer Institute
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research

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