Jean-François Mouscadet

Overview

Best Publications

• Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

  Isabelle Malet;Olivier Delelis;Marc-Antoine Valantin;Brigitte Montes

  353
  Citations

• Styrylquinoline Derivatives: A New Class of Potent HIV-1 Integrase Inhibitors That Block HIV-1 Replication in CEM Cells

  Khalid Mekouar;Jean-François Mouscadet;Didier Desmaële;Frédéric Subra

  329
  Citations

• Integrase and integration: biochemical activities of HIV-1 integrase.

  Olivier Delelis;Kevin Carayon;Ali Saïb;Eric Deprez

  305
  Citations

• Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections.

  Mohammed A. Fakhfakh;Alain Fournet;Alain Fournet;Eric Prina;Jean-François Mouscadet

  238
  Citations

• Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.

  F. Zouhiri;J.-F. Mouscadet;K. Mekouar;D. Desmaële

  223
  Citations

• Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

  Claire Séror;Marie Thérèse Melki;Frédéric Subra;Syed Qasim Raza;Syed Qasim Raza

  197
  Citations

• Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity.

  Elvire Guiot;Kevin Carayon;Olivier Delelis;Françoise Simon

  189
  Citations

• Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy.

  Eric Deprez;Patrick Tauc;Hervé Leh;Jean-François Mouscadet

  174
  Citations

• The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation.

  Olivier Delelis;Isabelle Malet;Li Na;Luba Tchertanov

  166
  Citations

• Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.

  S Carteau;S C Batson;L Poljak;J F Mouscadet

  164
  Citations

• Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase.

  Hervé Leh;Priscille Brodin;Julien Bischerour;Eric Deprez

  161
  Citations

• Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

  Muriel Billamboz;Fabrice Bailly;Maria Letizia Barreca;Laura De Luca

  158
  Citations

• Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.

  Christophe Bénard;Fatima Zouhiri;Marie Normand-Bayle;Michèle Danet

  140
  Citations

• Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines.

  Jaroslaw Polanski;Fatima Zouhiri;Laurence Jeanson;Didier Desmaële

  139
  Citations

• HIV-1 replication inhibitors of the styrylquinoline class: introduction of an additional carboxyl group at the C-5 position of the quinoline

  Fatima Zouhiri;Michèle Danet;Christophe Bénard;Marie Normand-Bayle

  124
  Citations

• Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

  Fabrice Michel;Corinne Crucifix;Florence Granger;Sylvia Eiler

  120
  Citations

• Styrylquinolines, Integrase Inhibitors Acting Prior to Integration: a New Mechanism of Action for Anti-Integrase Agents

  Sabine Bonnenfant;Claire Marie Thomas;Claudio Vita;Frédéric Subra

  120
  Citations

• Inhibition of human immunodeficiency virus type 1 reverse transcriptase, RNase H, and integrase activities by hydroxytropolones.

  Joël Didierjean;Catherine Isel;Flore Querré;Jean-François Mouscadet

  117
  Citations

• Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro.

  Eric Deprez;Sophie Barbe;Macieij Kolaski;Hervé Leh

  114
  Citations

• DNA binding induces dissociation of the multimeric form of HIV-1 integrase: A time-resolved fluorescence anisotropy study

  Eric Deprez;Patrick Tauc;Hervé Leh;Jean-François Mouscadet

  114
  Citations