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D-Index & Metrics

Biology and Biochemistry

D-Index
50
Citations
7683
World Ranking
17743
National Ranking
785

Overview

Christian Auclair is affiliated with the École Normale Supérieure Paris-Saclay in France. Their research spans several intersecting scientific fields, primarily focused on molecular biology, immunology, and oncology. This multidisciplinary interest is reflected in their contributions to biochemistry, genetics, molecular biology, immunology and microbiology, and medicine.

The scientist's body of work includes research on immunotherapy, alkaloid synthesis and bioactivity, cancer treatment pharmacology, sphingolipid metabolism and signaling, chemical synthesis and analysis, click chemistry applications, and protein interactions, specifically involving 14-3-3 proteins.

Christian Auclair has published extensively on topics related to:

  • Immunotherapy and Immune Responses
  • Synthesis and Bioactivity of Alkaloids
  • Cancer Treatment and Pharmacology
  • Sphingolipid Metabolism and Signaling
  • Chemical Synthesis and Analysis
  • Click Chemistry and Applications
  • 14-3-3 Protein Interactions

Their recent papers include:

  • The β-carboline Harmine improves the therapeutic benefit of anti-PD1 in melanoma by increasing the MHC-I-dependent antigen presentation (2022, Frontiers in Immunology)
  • The β-carboline Harmine Induces Actin Dynamic Remodeling and Abrogates the Malignant Phenotype in Tumorigenic Cells (2020, Cells)
  • Is Sphingosine-1-Phosphate a Regulator of Tumor Vascular Functionality? (2022, Cancers)
  • Sphingosine-1-Phosphate as Lung and Cardiac Vasculature Protecting Agent in SARS-CoV-2 Infection (2023, International Journal of Molecular Sciences)
  • The 'Holy Grail' in Immuno-Oncology: AC BioScience SA is Aiming to Potentiate Anti-PD-1 Therapy Efficacy through Tumor Cell Conditioning Strategy (2020, CHIMIA International Journal for Chemistry)

Frequent collaborators in their research include Manale Karam, Bassam Janji, Annette Ives, Muhammad Zaeem Noman, and Kris Van Moer. These collaborations indicate a network of scientific partnerships focused on cancer biology, immunology, and molecular pharmacology.

Christian Auclair's work has been published in several notable scientific venues such as:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Frontiers in Immunology
  • Cells
  • Cancers
  • International Journal of Molecular Sciences

Best Publications

  • Nitroblue Tetrazolium Reduction

    Christian Auclair;Emmanuelle Voisin

  • Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

    Patrice Dubreuil;Sébastien Letard;Marco Ciufolini;Laurent Gros

  • Styrylquinoline Derivatives: A New Class of Potent HIV-1 Integrase Inhibitors That Block HIV-1 Replication in CEM Cells

    Khalid Mekouar;Jean-François Mouscadet;Didier Desmaële;Frédéric Subra

  • Multimodal action of antitumor agents on DNA: The ellipticine series

    Christian Auclair

  • Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.

    F. Zouhiri;J.-F. Mouscadet;K. Mekouar;D. Desmaële

  • Antioxidants in Therapy and Preventive Medicine

    Ingrid Emerit;Lester Packer;Christian Auclair

  • Superoxide Dismutase, Catalase, and Glutathione Peroxidase in Red Blood Cells from Patients with Malignant Diseases

    Renée Gonzales;Christian Auclair;Emmanuelle Voisin;Huguette Gautero

  • Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

    Jesus S. Mora;Angela Genge;Adriano Chio;Conrado J. Estol

  • Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy.

    Eric Deprez;Patrick Tauc;Hervé Leh;Jean-François Mouscadet

  • Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.

    S Carteau;S C Batson;L Poljak;J F Mouscadet

  • Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase.

    Hervé Leh;Priscille Brodin;Julien Bischerour;Eric Deprez

  • EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice.

    Gregory Lambert;Jean Rémi Bertrand;Elias Fattal;Frédéric Subra

  • HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

    Jean-Benoît Arlet;Jean-Antoine Ribeil;Flavia Guillem;Olivier Negre

  • Superoxide dismutase assay using alkaline dimethylsulfoxide as superoxide anion-generating system.

    Keith Hyland;Emmanuelle Voisin;Hélène Banoun;Christian Auclair

  • BIOACTIVATION OF THE ANTITUMOR DRUGS 9-HYDROXYELLIPTICINE AND DERIVATIVES BY A PEROXIDASE-HYDROGEN PEROXIDE SYSTEM

    C. Auclair;C. Paoletti

  • Phenotypic and Functional Evidence for the Expression of CXCR4 Receptor During Megakaryocytopoiesis

    Christel Rivière;Frédéric Subra;Karine Cohen-Solal;Véronique Cordette-Lagarde

  • Masitinib for treatment of severely symptomatic indolent systemic mastocytosis: a randomised, placebo-controlled, phase 3 study

    Olivier Lortholary;Olivier Lortholary;Marie Olivia Chandesris;Cristina Bulai Livideanu;Carle Paul

  • Roles of stem cell factor/c-Kit and effects of Glivec/STI571 in human uveal melanoma cell tumorigenesis.

    Gaëlle Lefevre;Anne-Lise Glotin;Armelle Calipel;Frédéric Mouriaux

  • The formation of superoxide radical anions by a reaction between O2, OH- and dimethyl sulfoxide.

    K. Hyland;C. Auclair

  • Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro.

    Eric Deprez;Sophie Barbe;Macieij Kolaski;Hervé Leh

Frequent Co-Authors

Olivier Hermine
Olivier Hermine Necker-Enfants Malades Hospital
Bernard Meunier
Bernard Meunier Guangdong University of Technology
Laurence Zitvogel
Laurence Zitvogel University of Paris-Saclay
Ivan Bièche
Ivan Bièche Institute Curie
Jan Balzarini
Jan Balzarini KU Leuven
Jean-Louis Imbach
Jean-Louis Imbach Centre national de la recherche scientifique, CNRS
Priscille Brodin
Priscille Brodin University of Lille
Jean-Pierre Kinet
Jean-Pierre Kinet Beth Israel Deaconess Medical Center

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