Eva Frei

Overview

Best Publications

• Sudan I Is a Potential Carcinogen for Humans Evidence for Its Metabolic Activation and Detoxication by Human Recombinant Cytochrome P450 1A1 and Liver Microsomes

  Marie Stiborová;Václav Martínek;Helena Rýdlová;Petr Hodek

  403
  Citations

• Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances.

  Rene Kizek;Vojtech Adam;Jan Hrabeta;Tomas Eckschlager

  207
  Citations

• The anticancer agent ellipticine on activation by cytochrome P450 forms covalent DNA adducts.

  Marie Stiborová;Christian A. Bieler;Manfred Wiessler;Eva Frei

  207
  Citations

• The anticancer drug ellipticine forms covalent DNA adducts, mediated by human cytochromes P450, through metabolism to 13-hydroxyellipticine and ellipticine N2-oxide.

  Marie Stiborová;Jan Sejbal;Lucie Borek-Dohalská;Dagmar Aimová

  178
  Citations

• Human Enzymes Involved in the Metabolic Activation of Carcinogenic Aristolochic Acids: Evidence for Reductive Activation by Cytochromes P450 1A1 and 1A2

  Marie Stiborová;Eva Frei;Manfred Wiessler;Heinz H. Schmeiser

  172
  Citations

• Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

  Volker M. Arlt;Marie Stiborova;Colin J. Henderson;Martin R. Osborne

  170
  Citations

• Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

  Volker M. Arlt;Marie Stiborová;Colin J. Henderson;Markus Thiemann

  170
  Citations

• Native albumin for targeted drug delivery

  Elena Neumann;Eva Frei;Dorothee Funk;Matthias D Becker

  161
  Citations

• Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

  Marie Stiborová;Eva Frei;Volker M. Arlt;Heinz H. Schmeiser

  159
  Citations

• Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

  Marie Stiborová;Eva Frei;Bruno Sopko;Klára Sopková

  151
  Citations

• Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

  Marie Stiborová;Eva Frei;Petr Hodek;Manfred Wiessler

  139
  Citations

• Characterization of DNA adducts formed by aristolochic acids in the target organ (forestomach) of rats by 32P-postlabelling analysis using different chromatographic procedures

  Stiborová M;Fernando Rc;Schmeiser Hh;Frei E

  137
  Citations

• Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy

  Marie Stiborová;Eva Frei;Bruno Sopko;Manfred Wiessler

  135
  Citations

• Phase I trial of methotrexate-albumin in a weekly intravenous bolus regimen in cancer patients. Phase I Study Group of the Association for Medical Oncology of the German Cancer Society.

  Gernot Hartung;Gerd Stehle;Hannsjörg Sinn;Andreas Wunder

  130
  Citations

• Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium

  Shamik Das;Aniruddha Banerji;Eva Frei;Amitava Chatterjee

  124
  Citations

• Albumin binding ligands and albumin conjugate uptake by cancer cells.

  Eva Frei

  118
  Citations

• Comparison of DNA adduct formation by aristolochic acids in various in vitro activation systems by 32P-post-labelling : evidence for reductive activation by peroxidases

  H H Schmeiser;E Frei;M Wiessler;M Stiborova

  117
  Citations

• DNA adduct formation by the anticancer drug ellipticine in rats determined by 32P postlabeling.

  Marie Stiborová;Andrea Breuer;Dagmar Aimová;Martina Stiborová-Rupertová

  103
  Citations

• Rat microsomes activating the anticancer drug ellipticine to species covalently binding to deoxyguanosine in DNA are a suitable model mimicking ellipticine bioactivation in humans.

  Marie Stiborova;Martina Stiborova-Rupertova;Lucie Borek-Dohalska;Manfred Wiessler

  100
  Citations

• DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique.

  Marie Stiborová;Vilı́m Šimánek;Eva Frei;Pavel Hobza

  99
  Citations