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Biology and Biochemistry

D-Index
70
Citations
17538
World Ranking
7004
National Ranking
3224

Overview

Robert J. Gorelick is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within medicine, immunology, microbiology, and molecular biology.

The main fields of study in their work include:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these fields, they focus on several subfields such as:

  • Infectious Diseases
  • Virology
  • Molecular Biology
  • Ecology
  • Oncology

Their research covers important topics, including:

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • HIV/AIDS Research and Interventions
  • RNA Research and Splicing
  • RNA and protein synthesis mechanisms
  • Bacteriophages and microbial interactions
  • RNA modifications and cancer

Robert J. Gorelick has published extensively, with frequent contributions to venues such as:

  • UNC Libraries
  • Viruses
  • Journal of Virus Eradication
  • Cell Reports
  • Biophysical Journal

Some recent publications include:

  • Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking (2020, Cell Reports)
  • Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy (2022, Science Translational Medicine)
  • Stable Latent HIV Infection and Low-level Viremia Despite Treatment With the Broadly Neutralizing Antibody VRC07-523LS and the Latency Reversal Agent Vorinostat (2021, The Journal of Infectious Diseases)
  • Dynamic Shifts in the HIV Proviral Landscape During Long Term Combination Antiretroviral Therapy: Implications for Persistence and Control of HIV Infections (2020, Viruses)
  • Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection (2020, Scientific Reports)

The scientist has collaborated frequently with several researchers including:

  • Frank Maldarelli
  • Jorden L. Welker
  • Jeffrey D. Lifson
  • Kevin M. Weeks
  • Joseph J. Eron

Best Publications

  • Architecture and secondary structure of an entire HIV-1 RNA genome

    Joseph M. Watts;Kristen K. Dang;Robert J. Gorelick;Christopher W. Leonard

  • Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor–viral RNA interactions

    Anne-Sophie Beignon;Kelli McKenna;Mojca Skoberne;Olivier Manches

  • Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

    Marina Caskey;Florian Klein;Julio C. C. Lorenzi;Michael S. Seaman

  • Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA.

    R J Gorelick;S M Nigida;J W Bess;L O Arthur

  • Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

    Rebecca M. Lynch;Eli Boritz;Emily E. Coates;Adam DeZure

  • Point mutants of Moloney murine leukemia virus that fail to package viral RNA: evidence for specific RNA recognition by a "zinc finger-like" protein sequence

    Robert J. Gorelick;Louis E. Henderson;Janet P. Hanser;Alan Rein

  • High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states.

    Kevin A Wilkinson;Robert J Gorelick;Suzy M Vasa;Nicolas Guex

  • Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

    Francesco R. Simonetti;Michele D. Sobolewski;Elizabeth Fyne;Wei Shao

  • Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration

    Jean L. Mbisa;Rebekah Barr;James A. Thomas;Nick Vandegraaff

  • Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection.

    Donn J. Colby;Lydie Trautmann;Lydie Trautmann;Suteeraporn Pinyakorn;Suteeraporn Pinyakorn;Louise Leyre

  • The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent.

    R J Gorelick;D J Chabot;A Rein;L E Henderson

  • Microvesicles Are a Source of Contaminating Cellular Proteins Found in Purified HIV-1 Preparations

    Julian W. Bess;Robert J. Gorelick;William J. Bosche;Louis E. Henderson

  • Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

    Evguenia S. Svarovskaia;Hongzhan Xu;Jean L. Mbisa;Rebekah Barr

  • Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging.

    Kun Luo;Bindong Liu;Zuoxiang Xiao;Zuoxiang Xiao;Yunkai Yu

  • Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

    Julian H Elliott;James H McMahon;Christina C Chang;Christina C Chang;Sulggi A Lee

  • Zinc finger structures in the human immunodeficiency virus type 1 nucleocapsid protein facilitate efficient minus- and plus-strand transfer.

    Jianhui Guo;Tiyun Wu;Jada Anderson;Bradley F. Kane

  • HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro

    Ya-Xiong Feng;Terry D. Copeland;Louis E. Henderson;Robert J. Gorelick

  • Coupled integration of human immunodeficiency virus type 1 cDNA ends by purified integrase in vitro: stimulation by the viral nucleocapsid protein.

    Sandrine Carteau;Robert J. Gorelick;Frederic D. Bushman

  • Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes

    Jocelyn O. Eidahl;Brandon L. Crowe;Justin A. North;Christopher J. McKee

  • Mechanism for nucleic acid chaperone activity of HIV-1 nucleocapsid protein revealed by single molecule stretching.

    Mark C. Williams;Ioulia Rouzina;Jay R. Wenner;Robert J. Gorelick

Frequent Co-Authors

Karin Musier-Forsyth
Karin Musier-Forsyth The Ohio State University
Alan Rein
Alan Rein National Institutes of Health
Louis E. Henderson
Louis E. Henderson Science Applications International Corporation (United States)
Vinay K. Pathak
Vinay K. Pathak National Institutes of Health
Kevin M. Weeks
Kevin M. Weeks University of North Carolina at Chapel Hill
Judith G. Levin
Judith G. Levin National Institutes of Health
Larry O. Arthur
Larry O. Arthur Science Applications International Corporation (United States)
Kunio Nagashima
Kunio Nagashima National Institutes of Health
David E. Ott
David E. Ott Leidos (United States)
Robert J. Fisher
Robert J. Fisher Science Applications International Corporation (United States)

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