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Frauke Christ

Frauke Christ

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8047
World Ranking
18070
National Ranking
299

Overview

Frauke Christ is affiliated with KU Leuven in Belgium and has an extensive research portfolio primarily situated in the fields of Biochemistry, Genetics, and Molecular Biology as well as Medicine. Their work spans multiple subfields including Molecular Biology, Virology, Infectious Diseases, Pulmonary and Respiratory Medicine, and Genetics. The primary research topics cover HIV research and treatment, HIV/AIDS drug development and treatment, protein degradation and inhibitors, genetics and neurodevelopmental disorders, cystic fibrosis research advances, ubiquitin and proteasome pathways, and CRISPR and genetic engineering.

Their recent published works include the following papers:

  • "Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration" (2020) in Journal of Virology
  • "Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects" (2020) in Cells
  • "GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture" (2021) in Antimicrobial Agents and Chemotherapy
  • "Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids" (2022) in ERJ Open Research
  • "Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus" (2021) in Frontiers in Microbiology

Frauke Christ has collaborated frequently with a number of researchers including Zeger Debyser, Siska Van Belle, Rik Gijsbers, Marianne Carlon, and M. Ensinck. These collaborations are evidenced by multiple joint publications, with the highest number of co-authored works with Zeger Debyser.

Their research has been disseminated through various publication venues, with multiple articles appearing in bioRxiv (Cold Spring Harbor Laboratory) and the Journal of Cystic Fibrosis. Other notable journals where their work has been featured include Cells, Structure, and Viruses.

Best Publications

  • Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

    Frauke Christ;Arnout Voet;Arnaud Marchand;Stefan Nicolet;Stefan Nicolet

  • Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.

    Stéphane Emiliani;Aurélie Mousnier;Katrien Busschots;Marlène Maroun

  • Transportin-SR2 Imports HIV into the Nucleus

    Frauke Christ;Wannes Thys;Jan De Rijck;Rik Gijsbers

  • The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding

    Katrien Busschots;Jo Vercammen;Stéphane Emiliani;Richard Benarous

  • Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.

    Linos Vandekerckhove;Frauke Christ;Bénédicte Van Maele;Jan De Rijck

  • Cellular co-factors of HIV-1 integration.

    Bénédicte Van Maele;Katrien Busschots;Linos Vandekerckhove;Frauke Christ

  • Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

    Jan De Rijck;Linos Vandekerckhove;Rik Gijsbers;Anneleen Hombrouck

  • Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

    Frauke Christ;Stephen Shaw;Jonas Demeulemeester;Belete Ayele Desimmie

  • Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

    Serena Pasquini;Claudia Mugnaini;Cristina Tintori;Maurizio Botta

  • Identification of the LEDGF/p75 Binding Site in HIV-1 Integrase

    Katrien Busschots;Arnout Voet;Marc De Maeyer;Jean-Christophe Rain

  • Magnesium Chelating 2-Hydroxyisoquinoline-1,3(2H,4H)-diones, as Inhibitors of HIV-1 Integrase and/or the HIV-1 Reverse Transcriptase Ribonuclease H Domain: Discovery of a Novel Selective Inhibitor of the Ribonuclease H Function

    Muriel Billamboz;Fabrice Bailly;Cédric Lion;Nadia Touati;Nadia Touati

  • Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

    Anneleen Hombrouck;Jan De Rijck;Jelle Hendrix;Linos Vandekerckhove

  • LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

    Belete Ayele Desimmie;Rik Schrijvers;Jonas Demeulemeester;Doortje Borrenberghs

  • Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain

    Muriel Billamboz;Fabrice Bailly;Maria Letizia Barreca;Laura De Luca

  • LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

    Rik Schrijvers;Jan De Rijck;Jonas Demeulemeester;Noritaka Adachi

  • Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.

    Teshome L. Aboye;Helen Ha;Subhabrata Majumder;Frauke Christ

  • Pharmacophore-Based Discovery of Small-Molecule Inhibitors of Protein–Protein Interactions between HIV-1 Integrase and Cellular Cofactor LEDGF/p75

    Laura De Luca;Maria Letizia Barreca;Stefania Ferro;Frauke Christ

  • The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.

    Frauke Christ;Zeger Debyser

  • Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ

    Koen Bartholomeeusen;Frauke Christ;Jelle Hendrix;Jean-Christophe Rain

  • Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

    Koen Bartholomeeusen;Jan De Rijck;Katrien Busschots;Linda Desender

Frequent Co-Authors

Zeger Debyser
Zeger Debyser KU Leuven
Rik Gijsbers
Rik Gijsbers KU Leuven
Alba Chimirri
Alba Chimirri University of Messina
Maurizio Botta
Maurizio Botta University of Siena
Nouri Neamati
Nouri Neamati University of Michigan–Ann Arbor
Alfred Pingoud
Alfred Pingoud University of Giessen
Frederic D. Bushman
Frederic D. Bushman University of Pennsylvania

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