While working on this project, Frauke Christ studies both Integrase and Integrase inhibitor. Many of her studies on Integrase inhibitor apply to Viral load as well. Her Viral load study frequently links to related topics such as Human immunodeficiency virus (HIV). Her Human immunodeficiency virus (HIV) study frequently draws connections between related disciplines such as Antiretroviral therapy. As part of her studies on Antiretroviral therapy, she frequently links adjacent subjects like Raltegravir. Frauke Christ undertakes multidisciplinary studies into Raltegravir and Integrase in her work. Frauke Christ conducted interdisciplinary study in her works that combined Gene and Mutant. In her papers, she integrates diverse fields, such as Virology and Viral replication. Frauke Christ performs multidisciplinary studies into Viral replication and Virology in her work.
Frauke Christ undertakes multidisciplinary studies into Integrase and Integrase inhibitor in her work. She regularly ties together related areas like Antiretroviral therapy in her Integrase inhibitor studies. Her Human immunodeficiency virus (HIV) research extends to the thematically linked field of Antiretroviral therapy. Her Human immunodeficiency virus (HIV) study frequently links to adjacent areas such as Viral load. She performs multidisciplinary study in Viral load and Virology in her work. She connects Virology with Genetics in her study. Her study ties her expertise on Viral replication together with the subject of Genetics. In her research, Frauke Christ undertakes multidisciplinary study on Viral replication and Virus. She integrates Virus with Integrase in her study.
Frauke Christ is exploring In vitro as part of her EC50, Cytotoxicity, Structure–activity relationship, K562 cells and Lead compound and In vitro studies. Cytotoxicity is closely attributed to In vitro in her work. Many of her studies on Stereochemistry involve topics that are commonly interrelated, such as Nucleoside and Moiety. She incorporates Nucleoside and RNA in her research. She brings together RNA and Reverse transcriptase to produce work in her papers. Her Moiety study frequently draws connections between related disciplines such as Stereochemistry. Research on HEK 293 cells and K562 cells is a part of her Cell culture study. Frauke Christ brings together HEK 293 cells and Cell culture to produce work in her papers. Frauke Christ combines Gene and Gene silencing in her studies.
Frauke Christ brings together Genetics and Cancer research to produce work in her papers. Frauke Christ performs integrative study on Cancer research and Genetics. Her work blends Gene and Computational biology studies together. Frauke Christ undertakes interdisciplinary study in the fields of Computational biology and DNA through her research. She undertakes interdisciplinary study in the fields of DNA and Homology modeling through her works. Her research links Biochemistry with Homology modeling. Her Biochemistry study frequently involves adjacent topics like Lead compound. Her In vitro research extends to Lead compound, which is thematically connected. Frauke Christ performs multidisciplinary study in the fields of In vitro and In silico via her papers.
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Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
Frauke Christ;Arnout Voet;Arnaud Marchand;Stefan Nicolet;Stefan Nicolet.
Nature Chemical Biology (2010)
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.
Stéphane Emiliani;Aurélie Mousnier;Katrien Busschots;Marlène Maroun.
Journal of Biological Chemistry (2005)
Transportin-SR2 Imports HIV into the Nucleus
Frauke Christ;Wannes Thys;Jan De Rijck;Rik Gijsbers.
Current Biology (2008)
Cellular co-factors of HIV-1 integration.
Bénédicte Van Maele;Katrien Busschots;Linos Vandekerckhove;Frauke Christ.
Trends in Biochemical Sciences (2006)
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.
Linos Vandekerckhove;Frauke Christ;Bénédicte Van Maele;Jan De Rijck.
Journal of Virology (2006)
The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding
Katrien Busschots;Jo Vercammen;Stéphane Emiliani;Richard Benarous.
Journal of Biological Chemistry (2005)
Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication
Jan De Rijck;Linos Vandekerckhove;Rik Gijsbers;Anneleen Hombrouck.
Journal of Virology (2006)
Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization
Frauke Christ;Stephen Shaw;Jonas Demeulemeester;Belete Ayele Desimmie.
Antimicrobial Agents and Chemotherapy (2012)
Identification of the LEDGF/p75 Binding Site in HIV-1 Integrase
Katrien Busschots;Arnout Voet;Marc De Maeyer;Jean-Christophe Rain.
Journal of Molecular Biology (2007)
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Serena Pasquini;Claudia Mugnaini;Cristina Tintori;Maurizio Botta.
Journal of Medicinal Chemistry (2008)
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