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Neuroscience

D-Index
48
Citations
7351
World Ranking
6251
National Ranking
501

Overview

Karen Horsburgh is affiliated with the University of Edinburgh in the United Kingdom and has contributed extensively to the fields of neuroscience and medicine. Their work spans multiple subfields, including neurology, immunology, immunology and allergy, cellular and molecular neuroscience, and psychiatry and mental health.

The scientist's research frequently addresses key topics such as neuroinflammation and neurodegeneration mechanisms, neurological disease mechanisms and treatments, barrier structure and function studies, cell adhesion molecules research, immune cells in cancer, inflammation biomarkers and pathways, and cerebrovascular and genetic disorders.

Some of their recent publications include the following papers:

  • "Microglia regulate central nervous system myelin growth and integrity," 2022, Nature
  • "Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment," 2020, Journal of Neuroinflammation
  • "Impaired Glymphatic Function and Pulsation Alterations in a Mouse Model of Vascular Cognitive Impairment," 2022, Frontiers in Aging Neuroscience
  • "Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease," 2021, Journal of Cerebral Blood Flow & Metabolism
  • "Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke," 2022, Brain Pathology

The researcher frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature, Journal of Cerebral Blood Flow & Metabolism, Cerebral Circulation - Cognition and Behavior, and Journal of Neuroinflammation.

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Journal of Cerebral Blood Flow & Metabolism
  • Cerebral Circulation - Cognition and Behavior
  • Journal of Neuroinflammation

Karen Horsburgh collaborates regularly with several coauthors, including:

  • Stefan Szymkowiak
  • Barry W. McColl
  • Raj N. Kalaria
  • Stuart M. Allan
  • Juraj Koudelka

Best Publications

  • Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

    Sofia Papadia;Francesc X Soriano;Frédéric Léveillé;Marc-Andre Martel

  • Microglia regulate central nervous system myelin growth and integrity

    Unknown

  • Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia.

    Jessica Duncombe;Akihiro Kitamura;Yoshiki Hase;Masafumi Ihara

  • Apolipoprotein E and the CNS response to injury

    Daniel T. Laskowitz;Karen Horsburgh;Allen D. Roses;Allen D. Roses

  • The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models.

    Karen Horsburgh;Karen Horsburgh;Mark O McCarron;Fiona White;Fiona White;James A.R Nicoll

  • White matter degeneration in vascular and other ageing-related dementias

    Yoshiki Hase;Karen Horsburgh;Masafumi Ihara;Raj N. Kalaria

  • The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

    Marc-André Martel;Tomás J Ryan;Tomás J Ryan;Karen F.S. Bell;Jill H Fowler

  • Neuroprotection by a selective estrogen receptor β agonist in a mouse model of global ischemia

    Hilary Carswell;I.M. Macrae;L. Gallagher;E. Harrop

  • Impaired Neuronal Plasticity in Transgenic Mice Expressing Human Apolipoprotein E4 Compared to E3 in a Model of Entorhinal Cortex Lesion

    F. White;J.A.R. Nicoll;A.D. Roses;K. Horsburgh

  • The human NACP/alpha-synuclein gene: chromosome assignment to 4q21.3-q22 and TaqI RFLP analysis.

    Xiaohua Chen;H.A.Rohan de Silva;Mark J. Pettenati;P.Nagesh Rao

  • Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

    Aiqing Chen;Rufus O. Akinyemi;Yoshiki Hase;Michael J. Firbank

  • Mild fluid percussion injury in mice produces evolving selective axonal pathology and cognitive deficits relevant to human brain injury

    Aisling Spain;Stephanie Daumas;Jonathan Lifshitz;Jonathan Rhodes

  • Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

    Karen F. Bell;Bashayer Al-Mubarak;Jill H. Fowler;Paul S. Baxter

  • Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia.

    Maggie Lai;Karen Horsburgh;Sung-Eun Bae;Roderick N. Carter

  • Rapid Disruption of Axon–Glial Integrity in Response to Mild Cerebral Hypoperfusion

    Michell Mario Reimer;Jamie McQueen;Luke Searcy;Gillian Scullion

  • Extension of cerebral hypoperfusion and ischaemic pathology beyond MCA territory after intraluminal filament occlusion in C57Bl/6J mice

    Barry W. McColl;Hilary V. Carswell;James McCulloch;Karen Horsburgh

  • β‐Amyloid (Aβ)42(43), Aβ42, Aβ40 and apoE immunostaining of plaques in fatal head injury

    K. Horsburgh;K. Horsburgh;G. M. Cole;F. Yang;M. J. Savage

  • Alterations in ApoE and ApoJ in relation to degeneration and regeneration in a mouse model of entorhinal cortex lesion.

    F. White;J.A.R. Nicoll;K. Horsburgh

  • Selective alterations in the cellular distribution of apolipoprotein E immunoreactivity following transient cerebral ischaemia in the rat

    K. Horsburgh;J. A. R. Nicoll

  • Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia.

    Karen Horsburgh;Stephen Kelly;James McCulloch;Guy A. Higgins

  • Gliovascular disruption and cognitive deficits in a mouse model with features of small vessel disease

    Philip R Holland;James L Searcy;Natalia Salvadores;Gillian Scullion

Frequent Co-Authors

Masafumi Ihara
Masafumi Ihara Kyoto University
Philip R. Holland
Philip R. Holland King's College London
Raj N. Kalaria
Raj N. Kalaria Newcastle University
Giles E. Hardingham
Giles E. Hardingham University of Edinburgh
Seth Love
Seth Love University of Bristol
Emma R. Wood
Emma R. Wood University of Edinburgh
Joanna M. Wardlaw
Joanna M. Wardlaw University of Edinburgh
Ian J. Deary
Ian J. Deary University of Edinburgh
Mark E. Bastin
Mark E. Bastin University of Edinburgh
Rhian M. Touyz
Rhian M. Touyz McGill University Health Centre

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