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Neuroscience

D-Index
68
Citations
20423
World Ranking
2725
National Ranking
269

Biology and Biochemistry

D-Index
69
Citations
20513
World Ranking
7292
National Ranking
562

Research.com Recognitions

  • 2018 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Giles E. Hardingham is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily centers on neuroscience, biochemistry, genetics, molecular biology, and medicine, with notable focus on molecular biology, neurology, cellular and molecular neuroscience, physiology, and genetics. The scientist's work addresses mechanisms underlying neuroinflammation and neurodegeneration and explores topics such as neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, Alzheimer's disease research and treatments, amyotrophic lateral sclerosis (ALS) research, neurogenesis and neuroplasticity mechanisms, neurological disease mechanisms and treatments, and mitochondrial function and pathology.

Recent papers authored or coauthored by Hardingham include:

  • Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration, 2023, Nature Reviews Neurology
  • Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology, 2022, Nature Communications
  • Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis, 2021, Acta Neuropathologica
  • The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases, 2020, International Journal of Molecular Sciences
  • Microglial identity and inflammatory responses are controlled by the combined effects of neurons and astrocytes, 2021, Cell Reports

The scientist collaborates frequently with a number of coauthors, including Owen Dando, Siddharthan Chandran, Paul Baxter, Peter C. Kind, and Xin He.

Hardingham's work has been published extensively in venues such as bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, Brain Communications, Frontiers in Molecular Neuroscience, and Nature Communications.

Recognition for Hardingham's contributions includes being named a Fellow of the Royal Society of Edinburgh in 2018 and a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

    Giles E. Hardingham;Yuko Fukunaga;Hilmar Bading;Hilmar Bading

  • Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

    Giles E. Hardingham;Hilmar Bading

  • Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression

    Giles E. Hardingham;Sangeeta Chawla;Claire M. Johnson;Hilmar Bading

  • The Yin and Yang of NMDA receptor signalling.

    Giles E. Hardingham;Hilmar Bading

  • Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity.

    Giles E. Hardingham;Fiona J. L. Arnold;Hilmar Bading

  • Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

    Sofia Papadia;Francesc X Soriano;Frédéric Léveillé;Marc-Andre Martel

  • CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

    Sangeeta Chawla;Giles E. Hardingham;David R. Quinn;Hilmar Bading

  • Functional roles of reactive astrocytes in neuroinflammation and neurodegeneration

    Unknown

  • Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

    Bilada Bilican;Andrea Serio;Sami J. Barmada;Agnes Lumi Nishimura

  • A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication

    Giles E. Hardingham;Fiona J. L. Arnold;Hilmar Bading

  • Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations

    Rocío Rojo;Rocío Rojo;Anna Raper;Derya D. Ozdemir;Lucas Lefevre

  • Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

    Giles E. Hardingham;Sangeeta Chawla;Francisco H. Cruzalegui;Hilmar Bading

  • Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

    Giles E. Hardingham;Kim Q. Do

  • Nuclear Ca2+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

    Sofia Papadia;Patrick Stevenson;Neil R. Hardingham;Hilmar Bading

  • Coupling of the NMDA receptor to neuroprotective and neurodestructive events.

    Giles E. Hardingham

  • Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

    Philip Hasel;Owen Dando;Owen Dando;Zoeb Jiwaji;Paul Baxter

  • Influence of GluN2 subunit identity on NMDA receptor function

    D.J.A. Wyllie;M.R. Livesey;G.E. Hardingham

  • Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

    Unknown

  • Preconditioning Doses of NMDA Promote Neuroprotection by Enhancing Neuronal Excitability

    Francesc X. Soriano;Sofia Papadia;Frank Hofmann;Neil R. Hardingham

  • Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

    Jing-Dan Qiu;Yan-Wei Tan;Anna M. Hagenston;Marc-André Martel

  • Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes

    Paul S Baxter;Giles E Hardingham

  • Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated.

    Giles E Hardingham;Hilmar Bading

Frequent Co-Authors

David J. A. Wyllie
David J. A. Wyllie University of Edinburgh
Siddharthan Chandran
Siddharthan Chandran University of Edinburgh
Hilmar Bading
Hilmar Bading Heidelberg University
Peter C. Kind
Peter C. Kind University of Edinburgh
Karen Horsburgh
Karen Horsburgh University of Edinburgh
Thomas H. Gillingwater
Thomas H. Gillingwater University of Edinburgh
Seth G. N. Grant
Seth G. N. Grant University of Edinburgh
John D. Hayes
John D. Hayes University of Dundee
Colin Smith
Colin Smith University of Edinburgh
Andrew M. McIntosh
Andrew M. McIntosh University of Edinburgh

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