Michael Tymianski

Best Publications

• Unruptured intracranial aneurysms - Risk of rupture and risks of surgical intervention

  D. Wiebers;J. Whisnant;G. Forbes;I. Meissner

  2504
  Citations

• Glutamate receptors, neurotoxicity and neurodegeneration

  Anthony Lau;Michael Tymianski

  1338
  Citations

• Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

  Michelle Aarts;Yitao Liu;Lidong Liu;Shintaro Besshoh

  1255
  Citations

• Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity.

  Mark Arundine;Michael Tymianski;Michael Tymianski

  1115
  Citations

• Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

  Rita Sattler;Zhigang Xiong;Wei Yang Lu;Mathias Hafner

  1080
  Citations

• NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo.

  Yitao Liu;Tak Pan Wong;Michelle Aarts;Amanda Rooyakkers

  977
  Citations

• A key role for TRPM7 channels in anoxic neuronal death

  Michelle Aarts;Koji Iihara;Wen Li Wei;Zhi Gang Xiong

  928
  Citations

• Calcium, ischemia and excitotoxicity.

  Kinga Szydlowska;Kinga Szydlowska;Michael Tymianski

  887
  Citations

• Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.

  M. Arundine;M. Arundine;M. Tymianski;M. Tymianski

  870
  Citations

• Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons.

  M Tymianski;MP Charlton;PL Carlen;CH Tator

  764
  Citations

• Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death.

  Rita Sattler;Michael Tymianski

  724
  Citations

• Molecular mechanisms of calcium-dependent excitotoxicity

  Rita Sattler;Michael Tymianski

  631
  Citations

• Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial.

  Michael D Hill;Mayank Goyal;Bijoy K Menon;Raul G Nogueira

  601
  Citations

• The Natural History and Predictive Features of Hemorrhage From Brain Arteriovenous Malformations

  Leodante da Costa;M. Christopher Wallace;Karel G. ter Brugge;Cian O'Kelly

  488
  Citations

• Normal and Abnormal Calcium Homeostasis in Neurons: A Basis for the Pathophysiology of Traumatic and Ischemic Central Nervous System Injury

  Michael Tymianski;Charles H. Tator

  482
  Citations

• Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

  Douglas J. Cook;Lucy Teves;Michael Tymianski

  450
  Citations

• Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial

  Michael D Hill;Renee H Martin;David Mikulis;John H Wong

  431
  Citations

• Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity

  Rita Sattler;Milton P. Charlton;Mathias Hafner;Michael Tymianski

  364
  Citations

• Targeting NMDA receptors in stroke: new hope in neuroprotection

  Qiu Jing Wu;Qiu Jing Wu;Michael Tymianski;Michael Tymianski

  337
  Citations

• Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke.

  Elaine Besancon;Shuzhen Guo;Josephine Lok;Michael Tymianski

  319
  Citations

• Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.

  Hong-Shuo Sun;Michael F Jackson;Michael F Jackson;Loren J Martin;Karen Jansen

  317
  Citations

• Distinct roles of synaptic and extrasynaptic NMDA receptors in excitotoxicity.

  Rita Sattler;Zhigang Xiong;Wei Yang Lu;John F. MacDonald

  315
  Citations

• Cell-permeant Ca2+ chelators reduce early excitotoxic and ischemic neuronal injury in vitro and in vivo

  Michael Tymianski;M. Christopher Wallace;Igor Spigelman;Masaaki Uno

  269
  Citations

• PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors.

  Hong Cui;Amy Hayashi;Hong-Shuo Sun;Michael P. Belmares

  247
  Citations

• Effectiveness of PSD95 Inhibitors in Permanent and Transient Focal Ischemia in the Rat

  Hong-Shuo Sun;Tracy A. Doucette;Yitao Liu;Yuan Fang

  219
  Citations

• Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

  Francesc X. Soriano;Marc-Andre Martel;Sofia Papadia;Anne Vaslin

  182
  Citations