World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
98
Citations
35597
World Ranking
1388
National Ranking
26

Overview

Modesto Orozco is affiliated with the University of Barcelona in Spain and specializes in Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Materials Chemistry, Genetics, Ecology, and Infectious Diseases. Their research explores key topics such as RNA and protein synthesis mechanisms, DNA and nucleic acid chemistry, genomics and chromatin dynamics, protein structure and dynamics, advanced biosensing and bioanalysis techniques, bacteriophages and microbial interactions, as well as enzyme structure and function.

Orozco has contributed to several papers published in prominent journals, including:

  • Colibactin DNA-damage signature indicates mutational impact in colorectal cancer, 2020, Nature Medicine
  • 4D Genome Rewiring during Oncogene-Induced and Replicative Senescence, 2020, Molecular Cell
  • Impact of DNA methylation on 3D genome structure, 2021, Nature Communications
  • Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria, 2023, Science
  • Deciphering the mechanical code of the genome and epigenome, 2022, Nature Structural & Molecular Biology

The researcher frequently publishes in venues such as Nucleic Acids Research, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Biophysical Reviews, and Nature Structural & Molecular Biology.

Among their frequent collaborators are Adam Hospital, Federica Battistini, Miłosz Wieczór, Juan Aranda, and Pablo D. Dans, indicating active cooperation within a diverse research network.

Best Publications

  • Refinement of the AMBER Force Field for Nucleic Acids: Improving the Description of α/γ Conformers

    Alberto Pérez;Iván Marchán;Daniel Svozil;Daniel Svozil;Jiri Sponer;Jiri Sponer

  • Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

    Xose S. Puente;Magda Pinyol;Víctor Quesada;Laura Conde

  • Parmbsc1: a refined force field for DNA simulations

    Ivan Ivani;Pablo D Dans;Agnes Noy;Alberto Pérez

  • Non-coding recurrent mutations in chronic lymphocytic leukaemia

    Xose S. Puente;Silvia Beà;Rafael Valdés-Mas;Neus Villamor

  • Molecular dynamics simulations: advances and applications.

    Josep Ramon Goñi;Modesto Orozco;Josep L Gelpí

  • Theoretical Methods for the Description of the Solvent Effect in Biomolecular Systems.

    Orozco M;Luque Fj

  • Perspective on “Electrostatic interactions of a solute with a continuum. A direct utilization of ab initio molecular potentials for the prevision of solvent effects”

    F. Javier Luque;Josep Maria López;Modesto Orozco

  • Performance of Molecular Mechanics Force Fields for RNA Simulations: Stability of UUCG and GNRA Hairpins

    Pavel Banáš;Daniel Hollas;Marie Zgarbová;Petr Jurečka

  • TAUTOMERISM AND PROTONATION OF GUANINE AND CYTOSINE. IMPLICATIONS IN THE FORMATION OF HYDROGEN-BONDED COMPLEXES

    Carles Colominas;Francisco J. Luque;Modesto Orozco

  • Target flexibility: an emerging consideration in drug discovery and design.

    Pietro Cozzini;Glen E. Kellogg;Francesca Spyrakis;Donald J. Abraham

  • A systematic molecular dynamics study of nearest-neighbor effects on base pair and base pair step conformations and fluctuations in B-DNA

    Richard Lavery;Krystyna Zakrzewska;David Beveridge;Thomas C. Bishop

  • Is polarization important in cation-π interactions?

    Elena Cubero;F. Javier Luque;Modesto Orozco

  • Dynamics of B-DNA on the microsecond time scale.

    Alberto Perez;F. Javier Luque;Modesto Orozco

  • A consensus view of protein dynamics.

    Manuel Rueda;Carles Ferrer-Costa;Tim Meyer;Tim Meyer;Alberto Pérez

  • Hydrogen Bond versus Anti-Hydrogen Bond: A Comparative Analysis Based on the Electron Density Topology

    E. Cubero;M. Orozco;P. Hobza;F. J. Luque

  • Characterization of disease-associated single amino acid polymorphisms in terms of sequence and structure properties.

    Carles Ferrer-Costa;Modesto Orozco;Xavier de la Cruz

  • Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.

    Pilar Munoz-Ruiz;Laura Rubio;Esther Garcia-Palomero;Isabel Dorronsoro

  • New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.

    Camps P;El Achab R;Morral J;Muñoz-Torrero D

  • Correlated ab initio study of nucleic acid bases and their tautomers in the gas phase, in a microhydrated environment and in aqueous solutionDedicated to the memory of our friend and distinguished scientist Professor Peter Kollman.

    Semen A. Trygubenko;Tetyana V. Bogdan;Manuel Rueda;Modesto Orozco

  • Frontiers in Molecular Dynamics Simulations of DNA

    Alberto Pérez;F. Javier Luque;Modesto Orozco

  • On the performance of continuum solvation methods. A comment on "Universal approaches to solvation modeling".

    Andreas Klamt;Benedetta Mennucci;Jacopo Tomasi;Vincenzo Barone

  • Nature of base stacking : Reference quantum-chemical stacking energies in ten unique B-DNA base-pair steps

    Jiří Šponer;Petr Jurečka;Ivan Marchan;F. Javier Luque

  • SCRF calculation of the effect of water on the topology of the molecular electrostatic potential

    F. J. Luque;M. Orozco;P. K. Bhadane;S. R. Gadre

  • Evidence for transcript networks composed of chimeric RNAs in human cells.

    Sarah Djebali;Julien Lagarde;Philipp Kapranov;Vincent Lacroix

Frequent Co-Authors

F. Javier Luque
F. Javier Luque University of Barcelona
Alberto Perez
Alberto Perez University of Florida
Carlos González
Carlos González Spanish National Research Council
Ramon Eritja
Ramon Eritja Spanish National Research Council
Charles A. Laughton
Charles A. Laughton University of Nottingham
Xavier Barril
Xavier Barril University of Barcelona
Carlos Alemán
Carlos Alemán Universitat Politècnica de Catalunya
Rafael Franco
Rafael Franco University of Barcelona
Enric I. Canela
Enric I. Canela University of Barcelona
David Torrents
David Torrents Barcelona Supercomputing Center

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