World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
96
Citations
33286
World Ranking
860
National Ranking
480

Medicine

D-Index
96
Citations
33767
World Ranking
9668
National Ranking
4979

Overview

Lester Kobzik is affiliated with Harvard University in the United States and conducts research primarily in the fields of Medicine and Immunology and Microbiology. Their academic work spans several subfields, including Immunology, Molecular Biology, Infectious Diseases, Oncology, and Epidemiology.

The scientist's research covers a variety of topics, with notable focus areas including:

  • Tuberculosis Research and Epidemiology
  • Single-cell and spatial transcriptomics
  • CAR-T cell therapy research
  • Interferon and immune responses
  • Mycobacterium research and diagnosis
  • Immune cells in cancer
  • SARS-CoV-2 and COVID-19 Research

Lester Kobzik has frequently published in several venues, with multiple papers appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Cancer Research
  • Harvard Dataverse
  • Regular and Young Investigator Award Abstracts

Some recent papers authored or co-authored by Kobzik include:

  • Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity (2021, Science Advances)
  • The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas (2020, Journal of Clinical Investigation)
  • Activation of CB1R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury (2020, The Journal of Immunology)
  • Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis (2021, iScience)
  • Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity (2020, bioRxiv (Cold Spring Harbor Laboratory))

The scientist collaborates regularly with several co-authors who have contributed frequently alongside them, including:

  • Alex Chenchik
  • Mikhail Makhanov
  • Igor Kramnik
  • Shivraj M. Yabaji
  • Paul Diehl

Best Publications

  • An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation : I. The roles of minor H antigens and endotoxin

    Kenneth R. Cooke;Lester Kobzik;Thomas R. Martin;Joanne Brewer

  • Nitric oxide in skeletal muscle

    Lester Kobzik;Michael B. Reid;David S. Bredt;Jonathan S. Stamler

  • Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization.

    L. Kobzik;D. S. Bredt;C. J. Lowenstein;J. Drazen

  • Endothelial Nitric Oxide Synthase Targeting to Caveolae: SPECIFIC INTERACTIONS WITH CAVEOLIN ISOFORMS IN CARDIAC MYOCYTES AND ENDOTHELIAL CELLS *

    Olivier Feron;Laurent Belhassen;Lester Kobzik;Thomas W. Smith

  • Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

    Stefan Frantz;Lester Kobzik;Young-Dae Kim;Ryuji Fukazawa

  • Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice

    Jun-ichi Oyama;Charles Blais;Xiaoli Liu;Minying Pu

  • Reactive oxygen in skeletal muscle. I. Intracellular oxidant kinetics and fatigue in vitro.

    M. B. Reid;K. E. Haack;K. M. Franchek;P. A. Valberg

  • Ipr1 gene mediates innate immunity to tuberculosis.

    Hui Pan;Bo-Shiun Yan;Mauricio Rojas;Mauricio Rojas;Yuriy V. Shebzukhov;Yuriy V. Shebzukhov

  • Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

    Jean-Luc Balligand;D Ungureanu;R A Kelly;L Kobzik

  • The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

    C Gauthier;V Leblais;L Kobzik;J N Trochu

  • MicroRNA-181b regulates NF-κB–mediated vascular inflammation

    Xinghui Sun;Basak Icli;Akm Khyrul Wara;Nathan Belkin

  • Reciprocal Rb Inactivation and p16INK4 Expression in Primary Lung Cancers and Cell Lines

    Geoffrey I. Shapiro;Christian D. Edwards;Lester Kobzik;John Godleski

  • Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice.

    Shaw-Fang Yet;Mark A. Perrella;Matthew D. Layne;Chung-Ming Hsieh

  • Reactive oxygen species in pulmonary inflammation by ambient particulates.

    Florence Tao;Beatriz Gonzalez-Flecha;Lester Kobzik;Lester Kobzik

  • Nitric Oxide-dependent Parasympathetic Signaling Is Due to Activation of Constitutive Endothelial (Type III) Nitric Oxide Synthase in Cardiac Myocytes

    Jean-Luc Balligand;Lester Kobzik;Xinqiang Han;David M. Kaye

  • Endothelial type nitric oxide synthase in skeletal muscle fibers : mitochondrial relationships.

    L. Kobzik;B. Stringer;J. L. Balligand;M. B. Reid

  • Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium

    Stéphane Moniotte;Lester Kobzik;Olivier Feron;Jean-Noël Trochu

  • The Scavenger Receptor MARCO Is Required for Lung Defense against Pneumococcal Pneumonia and Inhaled Particles

    Mohamed Arredouani;Zhiping Yang;Yao Yu Ning;Guozhong Qin

  • Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement.

    M R Weiser;J P Williams;F D Moore;L Kobzik

  • A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease

    Mercy R. PrabhuDas;Cynthia L. Baldwin;Paul L. Bollyky;Dawn M.E. Bowdish

  • Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation.

    C. W. Frevert;Songlih Huang;Hadi Danaee;J. D. Paulauskis

Frequent Co-Authors

Herbert B. Hechtman
Herbert B. Hechtman Brigham and Women's Hospital
Francis D. Moore
Francis D. Moore Brigham and Women's Hospital
Thomas W. Smith
Thomas W. Smith University of California, Davis
Jonathan S. Stamler
Jonathan S. Stamler Case Western Reserve University
David C. Christiani
David C. Christiani Harvard University
William G. Austen
William G. Austen Harvard University
Jeffrey M. Drazen
Jeffrey M. Drazen Harvard University
Thomas Michel
Thomas Michel Brigham and Women's Hospital
Caroline A. Owen
Caroline A. Owen Brigham and Women's Hospital
David L. Perkins
David L. Perkins University of New Mexico

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