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Biology and Biochemistry

D-Index
56
Citations
12209
World Ranking
14362
National Ranking
6050

Overview

Caroline A. Owen is affiliated with Brigham and Women's Hospital in the United States and has a research focus primarily in Medicine and Biochemistry, Genetics and Molecular Biology. Their work emphasizes Pulmonary and Respiratory Medicine, with significant contributions to Molecular Biology, Oncology, Genetics, and Physiology.

The scientist's research spans topics including:

  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Cystic Fibrosis Research Advances
  • Peptidase Inhibition and Analysis
  • Nematode Management and Characterization Studies
  • Neonatal Respiratory Health Research
  • Protease and Inhibitor Mechanisms
  • Cardiac Fibrosis and Remodeling

Recent scientific papers by Caroline A. Owen cover a range of respiratory and molecular medicine subjects. These include:

  • Association of clonal hematopoiesis with chronic obstructive pulmonary disease, 2021, Blood
  • Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment, 2021, American Journal of Respiratory and Critical Care Medicine
  • A phase 3, double-blind, parallel-group study to evaluate the efficacy and safety of tezacaftor in combination with ivacaftor in participants 6 through 11 years of age with cystic fibrosis homozygous for F508del or heterozygous for the F508del-CFTR mutation and a residual function mutation, 2020, Journal of Cystic Fibrosis
  • Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study, 2021, The Lancet Respiratory Medicine
  • Long-term safety and efficacy of lumacaftor-ivacaftor therapy in children aged 6-11 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a phase 3, open-label, extension study, 2021, The Lancet Respiratory Medicine

Caroline A. Owen frequently collaborates with several researchers, including:

  • Xiaoyun Wang
  • Duo Zhang
  • Joselyn Rojas
  • Francesca Polverino
  • Yohannes Tesfaigzi

Their publications often appear in key journals in pulmonary and respiratory medicine fields, such as:

  • American Journal of Respiratory and Critical Care Medicine
  • Journal of Cystic Fibrosis
  • The Lancet Respiratory Medicine
  • American Journal of Respiratory Cell and Molecular Biology
  • Physiological Reports

Best Publications

  • Lung-Function Trajectories Leading to Chronic Obstructive Pulmonary Disease

    Peter Lange;Bartolome Celli;Alvar Agustí;Gorm Boje Jensen

  • Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

    Kenji Mizumura;Kenji Mizumura;Kenji Mizumura;Suzanne M. Cloonan;Suzanne M. Cloonan;Kiichi Nakahira;Kiichi Nakahira;Abhiram R. Bhashyam

  • The cell biology of leukocyte-mediated proteolysis.

    Caroline A. Owen;Edward J. Campbell

  • Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases.

    Caroline A. Owen;Melody A. Campbell;Philip L. Sannes;Steve S. Boukedes

  • Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

    Vanessa J. Craig;Vanessa J. Craig;Li Zhang;James S. Hagood;James S. Hagood;Caroline A. Owen;Caroline A. Owen

  • CD8+ T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice.

    Toshitaka Maeno;A. McGarry Houghton;A. McGarry Houghton;Pablo A. Quintero;Sandra Grumelli

  • Quantum Proteolysis by Neutrophils: Implications for Pulmonary Emphysema in α1-Antitrypsin Deficiency

    Edward J. Campbell;M.A. Campbell;S.S. Boukedes;Caroline A. Owen

  • Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

    Hilaire C. Lam;Hilaire C. Lam;Hilaire C. Lam;Suzanne M. Cloonan;Abhiram R. Bhashyam;Jeffery A. Haspel

  • Membrane-Bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells Is a Potent, Tissue Inhibitor of Metalloproteinase-Resistant Collagenase and Serpinase

    Caroline A. Owen;Zhuma Hu;Carlos Lopez-Otin;Steven D. Shapiro

  • Neutrophil Elastase in Human Atherosclerotic Plaques Production by Macrophages

    Clare M. Dollery;Caroline A. Owen;Galina K. Sukhova;Alexandra Krettek

  • Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

    Suzanne M. Cloonan;Suzanne M. Cloonan;Kimberly Glass;Kimberly Glass;Maria E. Laucho-Contreras;Abhiram R. Bhashyam

  • Bioactive Proteinase 3 on the Cell Surface of Human Neutrophils: Quantification, Catalytic Activity, and Susceptibility to Inhibition

    Edward J. Campbell;Melody A. Campbell;Caroline A. Owen

  • Leukocyte proteinases in wound healing: roles in physiologic and pathologic processes.

    Brooke Barrick;Edward J. Campbell;Caroline A. Owen

  • Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease

    Caroline A Owen

  • Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity

    C. A. Owen;M. A. Campbell;S. S. Boukedes;E. J. Campbell

  • Association of Clonal Hematopoiesis with Chronic Obstructive Pulmonary Disease.

    Peter G. Miller;Peter G. Miller;Dandi Qiao;Joselyn Rojas-Quintero;Michael C. Honigberg;Michael C. Honigberg

  • Protective role for club cell secretory protein-16 (CC16) in the development of COPD.

    Maria E. Laucho-Contreras;Francesca Polverino;Kushagra Gupta;Katherine L. Taylor

  • Angiotensin II generation at the cell surface of activated neutrophils: novel cathepsin G-mediated catalytic activity that is resistant to inhibition.

    Caroline A. Owen;Edward J. Campbell

  • ADAM-33 surfaces as an asthma gene.

    Steven D. Shapiro;Caroline A. Owen

  • Inducible expression of tissue inhibitor of metalloproteinases-resistant matrix metalloproteinase-9 on the cell surface of neutrophils.

    Caroline A. Owen;Zhuma Hu;Brooke Barrick;Steven D. Shapiro

Frequent Co-Authors

Bartolome R. Celli
Bartolome R. Celli Brigham and Women's Hospital
Edward J. Campbell
Edward J. Campbell University of Utah
Edwin K. Silverman
Edwin K. Silverman Brigham and Women's Hospital
Augustine M. K. Choi
Augustine M. K. Choi Cornell University
Stefan W. Ryter
Stefan W. Ryter Cornell University
Lynette M. Sholl
Lynette M. Sholl Brigham and Women's Hospital
Steven D. Shapiro
Steven D. Shapiro University of Southern California
Xiaobo Zhou
Xiaobo Zhou The University of Texas Health Science Center at Houston
Claire E. Wainwright
Claire E. Wainwright University of Queensland
John Quackenbush
John Quackenbush Harvard University

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