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Neuroscience
Spain
2026
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Medicine
Spain
2023

D-Index & Metrics

Neuroscience

D-Index
115
Citations
39517
World Ranking
459
National Ranking
1

Medicine

D-Index
115
Citations
39511
World Ranking
4608
National Ranking
64

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Spain Leader Award
  • 2025 - Research.com Neuroscience in Spain Leader Award
  • 2023 - Research.com Medicine in Spain Leader Award
  • 2022 - Research.com Neuroscience in Spain Leader Award

Overview

Luis M. Garcia-Segura is affiliated with the Spanish National Research Council in Spain. Their research spans multiple interconnected fields including biochemistry, genetics and molecular biology, medicine, and neuroscience. Within these areas, they focus on subfields such as molecular biology, genetics, physiology, endocrinology, diabetes and metabolism, and behavioral neuroscience.

The scientist's work addresses several main topics, such as:

  • Stress Responses and Cortisol
  • Estrogen and related hormone effects
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Hypothalamic control of reproductive hormones
  • Menopause: Health Impacts and Treatments
  • Neuroendocrine regulation and behavior

Recent publications authored or coauthored by Luis M. Garcia-Segura reflect these research themes. Selected papers include:

  • Aging and sex: Impact on microglia phagocytosis (2020, Aging Cell)
  • Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging (2021, Mechanisms of Ageing and Development)
  • Estradiol-dependent axogenesis and Ngn3 expression are determined by XY sex chromosome complement in hypothalamic neurons (2020, Scientific Reports)
  • Tibolone as Hormonal Therapy and Neuroprotective Agent (2020, Trends in Endocrinology and Metabolism)
  • The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge (2020, Journal of Neuroinflammation)

The scientist frequently publishes in journals such as The Journal of Steroid Biochemistry and Molecular Biology, Frontiers in Neuroendocrinology, Mechanisms of Ageing and Development, International Journal of Molecular Sciences, and Frontiers in Neuroanatomy.

Collaborations form a significant aspect of Luis M. Garcia-Segura's research efforts. Frequent coauthors include María-Ángeles Arévalo, Daniela Grassi, George E. Barreto, Roberto Cosimo Melcangi, and Silvia Giatti.

Best Publications

  • The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

    Michael A Cowley;Roy G Smith;Sabrina Diano;Matthias Tschöp

  • Neuroprotection by estradiol.

    Luis Miguel Garcia-Segura;Iñigo Azcoitia;Lydia L. DonCarlos

  • The neuroprotective actions of oestradiol and oestrogen receptors

    Maria-Angeles Arevalo;Iñigo Azcoitia;Luis M. Garcia-Segura

  • Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease

    Ricardo Cabezas;Marcos Ávila;Janneth Gonzalez;Ramon Santos El-Bachá

  • Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repair.

    L.M. Garcia-Segura;L.M. Garcia-Segura;A. Wozniak;I. Azcoitia;I. Azcoitia;J.R. Rodriguez

  • Steroid hormones and neurosteroids in normal and pathological aging of the nervous system

    Martin Schumacher;Sebastien Weill-Engerer;Philippe Liere;Francoise Robert

  • Estradiol upregulates Bcl-2 expression in adult brain neurons.

    Luis M. Garcia-Segura;Patricia Cardona-Gomez;Frederick Naftolin;Julie A. Chowen

  • Role of astroglia in estrogen regulation of synaptic plasticity and brain repair.

    Luis Miguel Garcia‐Segura;Frederick Naftolin;John B. Hutchison;Iñigo Azcoitia

  • Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms

    Luis M. García-Segura;Julie A. Chowen;A. Párducz;F. Naftolin

  • Brain aromatase is neuroprotective.

    Iñigo Azcoitia;Amanda Sierra;Sergio Veiga;Shin‐ichiro Honda

  • Glial expression of estrogen and androgen receptors after rat brain injury.

    Daniel García-Ovejero;Sergio Veiga;Luis Miguel García-Segura;Lydia L. Doncarlos

  • Immunohistochemical mapping of calcium-binding protein immunoreactivity in the rat central nervous system

    L.M. Garcia-Segura;D. Baetens;J. Roth;A.W. Norman;A.W. Norman

  • Localization of Estrogen receptor β-immunoreactivity in astrocytes of the adult rat brain

    Iñigo Azcoitia;Amanda Sierra;Luis Miguel Garcia‐Segura

  • Steroids and glial cell function.

    Luis M. Garcia-Segura;Roberto C. Melcangi

  • Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury

    J. Garcia-Estrada;J.A. Del Rio;S. Luquin;E. Soriano

  • Neuroactive steroids: State of the art and new perspectives

    R. C. Melcangi;Luis M. García-Segura;A. G. Mensah-Nyagan

  • Estradiol synthesis within the human brain.

    I. Azcoitia;Josué G. Yagüe;Luis M. García-Segura

  • Aromatase in the Brain: Not Just for Reproduction Anymore

    Luis M. García-Segura

  • Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones.

    Daniel Garcia-Ovejero;Iñigo Azcoitia;Lydia L. DonCarlos;Roberto C. Melcangi

  • Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

    Yolanda Diz-Chaves;Olga Pernía;Paloma Carrero;Luis M Garcia-Segura

  • Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus

    P Cardona-Gomez;P Cardona-Gomez;M Perez;J Avila;L.M Garcia-Segura

Frequent Co-Authors

Roberto C. Melcangi
Roberto C. Melcangi University of Milan
Frederick Naftolin
Frederick Naftolin New York University
George E. Barreto
George E. Barreto University of Limerick
Donatella Caruso
Donatella Caruso University of Milan
Ignacio Torres-Aleman
Ignacio Torres-Aleman Achucarro Basque Center for Neuroscience
Tamas L. Horvath
Tamas L. Horvath Yale University
Guido Cavaletti
Guido Cavaletti University of Milano-Bicocca
Amanda Sierra
Amanda Sierra University of the Basque Country
Giancarlo Panzica
Giancarlo Panzica University of Turin
Nico Mitro
Nico Mitro University of Milan

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