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Neuroscience

D-Index
42
Citations
24098
World Ranking
7498
National Ranking
124

Overview

Amanda Sierra is affiliated with the University of the Basque Country in Spain and has contributed extensively to the fields of Neuroscience as well as Immunology and Microbiology. Their research spans several subfields including Neurology, Immunology, Molecular Biology, Physiology, and Epidemiology.

The primary focus of their work lies in understanding mechanisms related to neuroinflammation, neurodegeneration, and immune system regulation. Specific topics frequently addressed in their publications include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Immune cells in cancer
  • Phagocytosis and Immune Regulation
  • Immune Response and Inflammation
  • Autophagy in Disease and Therapy
  • Neurogenesis and neuroplasticity mechanisms
  • Fatty Acid Research and Health

Amanda Sierra has authored and co-authored numerous papers appearing in multiple scientific venues. Notable frequent publication sources include bioRxiv (Cold Spring Harbor Laboratory), IBRO Neuroscience Reports, Frontiers in Immunology, Neuron, and Glia.

Their recent scholarly articles include:

  • Microglia states and nomenclature: A field at its crossroads (2022), published in Neuron
  • Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome (2020), published in Journal of Neuroscience
  • Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain (2020), published in Nature Communications
  • Microglial Corpse Clearance: Lessons From Macrophages (2020), published in Frontiers in Immunology
  • Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis (2023), published in Cell Death and Disease

Collaboration is a significant aspect of their scientific output, with frequent co-authors including Jorge Valero, Ainhoa Plaza-Zabala, María Domercq, Virginia Sierra-Torre, and Noelia Rodríguez-Iglesias. These collaborations reflect sustained partnerships within a network focused on related research areas in neuroimmunology and cellular neuroscience.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Microglia states and nomenclature: A field at its crossroads

    Unknown

  • Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

    Amanda Sierra;Juan M. Encinas;Juan M. Encinas;Juan J.P. Deudero;Jessica H. Chancey

  • The Role of Microglia in the Healthy Brain

    Marie-Ève Tremblay;Beth Stevens;Amanda Sierra;Hiroaki Wake

  • Microglia derived from aging mice exhibit an altered inflammatory profile.

    Amanda Sierra;Andres C. Gottfried-Blackmore;Bruce S. McEwen;Karen Bulloch

  • Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

    Katharine Askew;Kaizhen Li;Adrian Olmos-Alonso;Fernando Garcia-Moreno

  • Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

    Amanda Sierra;Oihane Abiega;Anahita Shahraz;Harald Neumann

  • Steroid hormone receptor expression and function in microglia

    Amanda Sierra;Andres Gottfried-Blackmore;Teresa A. Milner;Teresa A. Milner;Bruce S. McEwen

  • Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome.

    Irune Diaz-Aparicio;Iñaki Paris;Virginia Sierra-Torre;Ainhoa Plaza-Zabala

  • Brain aromatase is neuroprotective.

    Iñigo Azcoitia;Amanda Sierra;Sergio Veiga;Shin‐ichiro Honda

  • Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging.

    Ainhoa Plaza-Zabala;Virginia Sierra-Torre;Amanda Sierra;Amanda Sierra

  • Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.

    Amanda Sierra;Amanda Sierra;Soraya Martín-Suárez;Roberto Valcárcel-Martín;Jesús Pascual-Brazo

  • Localization of Estrogen receptor β-immunoreactivity in astrocytes of the adult rat brain

    Iñigo Azcoitia;Amanda Sierra;Luis Miguel Garcia‐Segura

  • Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

    Amanda Sierra;Sol Beccari;Irune Diaz-Aparicio;Juan M. Encinas

  • The “Big‐Bang” for modern glial biology: Translation and comments on Pío del Río‐Hortega 1919 series of papers on microglia

    Amanda Sierra;Amanda Sierra;Fernando de Castro;Juan del Río-Hortega;José Rafael Iglesias-Rozas

  • Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling.

    Iñigo Azcoitia;Amanda Sierra;Luis M. Garcia-Segura

  • Cien Años de Microglía: Milestones in a Century of Microglial Research

    Amanda Sierra;Rosa C. Paolicelli;Helmut Kettenmann

  • Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

    Oihane Abiega;Sol Beccari;Irune Diaz-Aparicio;Agnes Nadjar

  • Aromatase: a neuroprotective enzyme.

    Luis M Garcia-Segura;Sergio Veiga;Sergio Veiga;Amanda Sierra;Roberto C Melcangi

  • Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

    C. Madore;Q. Leyrolle;L. Morel;M. Rossitto

  • An antagonist of estrogen receptors blocks the induction of adult neurogenesis by insulin-like growth factor-I in the dentate gyrus of adult female rat.

    Margarita Perez‐Martin;Iñigo Azcoitia;Jose Luis Trejo;Amanda Sierra

  • Aromatase Expression by Reactive Astroglia Is Neuroprotective

    Iñigo Azcoitia;Amanda Sierra;Sergio Veiga;Luis M. Garcia-Segura

Frequent Co-Authors

Luis M. Garcia-Segura
Luis M. Garcia-Segura Spanish National Research Council
Marie-Ève Tremblay
Marie-Ève Tremblay University of Victoria
Anne E. Anderson
Anne E. Anderson Baylor College of Medicine
Bruce S. McEwen
Bruce S. McEwen Rockefeller University
Sophie Layé
Sophie Layé University of Bordeaux
Hiroaki Wake
Hiroaki Wake Kobe University
Teresa A. Milner
Teresa A. Milner Cornell University
Helmut Kettenmann
Helmut Kettenmann Shenzhen Institutes of Advanced Technology
Oleg Butovsky
Oleg Butovsky Brigham and Women's Hospital
Anna-Elina Lehesjoki
Anna-Elina Lehesjoki University of Helsinki

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