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Biology and Biochemistry

D-Index
48
Citations
11860
World Ranking
18246
National Ranking
584

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Simona Polo is affiliated with the University of Milan in Italy, specializing in fields intersecting biochemistry, genetics, molecular biology, and medicine. Their work spans a variety of subfields including molecular biology, cell biology, epidemiology, genetics, and oncology.

Their research focuses primarily on topics related to ubiquitin and proteasome pathways, autophagy in disease and therapy, protein degradation and inhibitors, cellular transport and secretion, genomics and chromatin dynamics, cellular mechanics and interactions, as well as RNA research and splicing.

Simona Polo has contributed to numerous publications, with recent significant papers including:

  • Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH (2024) in Molecular Cell
  • BioE3 identifies specific substrates of ubiquitin E3 ligases (2023) in Nature Communications
  • The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress (2021) in Cell Reports
  • A p62-dependent rheostat dictates micronuclei catastrophe and chromosome rearrangements (2024) in Science
  • Listeria monocytogenes Exploits Host Caveolin for Cell-to-Cell Spreading (2020) in mBio

Their work has been published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Molecular Cell, Cell Reports, Nature Communications, and Science.

Collaborations have been an important part of their research, with frequent co-authors including Elena Maspero, Vincenzo Taibi, Valeria Cancila, Claudio Tripodo, and Fabio Giavazzi.

Recognition for their scientific contributions includes membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

    Kaisa Haglund;Sara Sigismund;Simona Polo;Iwona Szymkiewicz

  • Clathrin-independent endocytosis of ubiquitinated cargos

    Sara Sigismund;Tanja Woelk;Claudia Puri;Elena Maspero

  • A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

    Simona Polo;Sara Sigismund;Mario Faretta;Monica Guidi

  • Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation.

    Sara Sigismund;Elisabetta Argenzio;Daniela Tosoni;Elena Cavallaro

  • When ubiquitin meets ubiquitin receptors: a signalling connection

    Pier Paolo Di Fiore;Simona Polo;Kay Hofmann

  • Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.

    Sara Sigismund;Stefano Confalonieri;Andrea Ciliberto;Simona Polo

  • Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.

    Lorenza Penengo;Marina Mapelli;Andrea G. Murachelli;Stefano Confalonieri

  • Endocytosis Conducts the Cell Signaling Orchestra

    Simona Polo;Pier Paolo Di Fiore

  • Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes

    Metello Innocenti;Silke Gerboth;Klemens Rottner;Frank P. L. Lai

  • Ubiquitin in trafficking: the network at work.

    Filippo Acconcia;Sara Sigismund;Simona Polo

  • Molecular mechanisms of coupled monoubiquitination

    Tanja Woelk;Barbara Oldrini;Elena Maspero;Stefano Confalonieri

  • USP15 is a deubiquitylating enzyme for receptor-activated SMADs

    Masafumi Inui;Andrea Manfrin;Anant Mamidi;Graziano Martello

  • Signaling Through Monoubiquitination

    S. Sigismund;S. Polo;P. P. Di Fiore

  • The ubiquitination code: a signalling problem

    Tanja Woelk;Sara Sigismund;Lorenza Penengo;Simona Polo

  • Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.

    Yuxin Mao;Francesca Senic-Matuglia;Pier Paolo Di Fiore;Simona Polo

  • N-WASP deficiency impairs EGF internalization and actin assembly at clathrin-coated pits

    Stefanie Benesch;Simona Polo;Frank P. L. Lai;Kurt I. Anderson

  • Threshold‐controlled ubiquitination of the EGFR directs receptor fate

    Sara Sigismund;Veronica Algisi;Gilda Nappo;Alexia Conte

  • C–C Chemokines Released by Lipopolysaccharide (LPS)-stimulated Human Macrophages Suppress HIV-1 Infection in Both Macrophages and T Cells

    Alessia Verani;Gabriella Scarlatti;Manola Comar;Eleonora Tresoldi

  • Endocytosis and cancer

    Simona Polo;Salvatore Pece;Pier Paolo Di Fiore

  • Multiple monoubiquitination of RTKs is sufficient for their endocytosis and

    Kaisa Haglund;Sara Sigismund;Simona Polo;Iwona Szymkiewicz

Frequent Co-Authors

Pier Paolo Di Fiore
Pier Paolo Di Fiore University of Milan
Paolo Lusso
Paolo Lusso National Institutes of Health
Stefano Confalonieri
Stefano Confalonieri European Institute of Oncology
Gianni Cesareni
Gianni Cesareni University of Rome Tor Vergata
Aurélien Roux
Aurélien Roux University of Geneva
Klemens Rottner
Klemens Rottner Technische Universität Braunschweig
Andrea Musacchio
Andrea Musacchio Max Planck Society
Luisa Castagnoli
Luisa Castagnoli University of Rome Tor Vergata
Gabriella Scarlatti
Gabriella Scarlatti Vita-Salute San Raffaele University
Carlo Tacchetti
Carlo Tacchetti Vita-Salute San Raffaele University

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