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D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
20916
World Ranking
5890
National Ranking
210

Overview

Daniela Rotin is affiliated with the University of Toronto in Canada and has made contributions primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Pulmonary and Respiratory Medicine, Cell Biology, Cancer Research, and Genetics.

The scientist's research touches on various key topics such as Ubiquitin and proteasome pathways, Ion Transport and Channel Regulation, Neonatal Respiratory Health Research, Mitochondrial Function and Pathology, Cystic Fibrosis Research Advances, ATP Synthase and ATPases Research, and Genomics, phytochemicals, and oxidative stress.

Some of the recent papers authored or co-authored by Daniela Rotin include:

  • Function and Regulation of the Epithelial Na+ChannelENaC, 2021, Comprehensive physiology
  • Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2, 2023, Physiology
  • Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice, 2020, Nature Communications
  • High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids, 2021, Cells
  • Inhibition of eEF2K synergizes with glutaminase inhibitors or 4EBP1 depletion to suppress growth of triple-negative breast cancer cells, 2021, Scientific Reports

Frequent co-authors collaborating with Daniela Rotin include:

  • Chong Jiang
  • Avinash K. Persaud
  • Zetao Liu
  • Wael L. Demian
  • George Kefalas

The scientist's publications are often found in journals such as Scientific Reports, Nature Communications, Comprehensive Physiology, bioRxiv (Cold Spring Harbor Laboratory), and Research Square (Research Square).

Best Publications

  • Acid pH in Tumors and Its Potential for Therapeutic Exploitation

    Ian F. Tannock;Daniela Rotin

  • Physiological functions of the HECT family of ubiquitin ligases

    Daniela Rotin;Sharad Kumar

  • WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

    O. Staub;S. Dho;P. C. Henry;J. Correa

  • Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation.

    Sergio Grinstein;Daniela Rotin;Michael J. Mason

  • Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.

    O. Staub;I. Gautschi;T. Ishikawa;K. Breitschopf

  • Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

    A G Batzer;D Rotin;J M Ureña;E Y Skolnik

  • A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

    M Mohammadi;A M Honegger;D Rotin;R Fischer

  • Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases.

    D. Rotin;O. Staub;R. Haguenauer-Tsapis

  • SH3 domains direct cellular localization of signaling molecules

    D. Bar-Sagi;D. Rotin;A. Batzer;V. Mandiyan

  • Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome

    Hugues Abriel;Johannes Loffing;John F. Rebhun;J. Howard Pratt

  • SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.

    D. Rotin;B. Margolis;M. Mohammadi;R.J. Daly

  • Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain

    Silke Wiesner;Abiodun A. Ogunjimi;Hong-Rui Wang;Daniela Rotin

  • A strategy for modulation of enzymes in the ubiquitin system.

    Andreas Ernst;George Avvakumov;Jiefei Tong;Yihui Fan

  • The Grb10/Nedd4 Complex Regulates Ligand-Induced Ubiquitination and Stability of the Insulin-Like Growth Factor I Receptor

    Andrea Vecchione;Adriano Marchese;Pauline Henry;Daniela Rotin

  • An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.

    D Rotin;D Bar-Sagi;H O'Brodovich;J Merilainen

  • Role of ubiquitylation in cellular membrane transport.

    Olivier Staub;Daniela Rotin

  • Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination.

    Olivier Staub;Hugues Abriel;Pamela Plant;Toru Ishikawa

  • Solution structure of a Nedd4 WW domain-ENaC peptide complex.

    Voula Kanelis;Daniela Rotin;Julie D. Forman-Kay

  • Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism.

    S Grinstein;M Woodside;C Sardet;J Pouyssegur

  • Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants.

    L. Fialkow;Chi Kin Chan;D. Rotin;S. Grinstein

Frequent Co-Authors

Olivier Staub
Olivier Staub University of Lausanne
Julie D. Forman-Kay
Julie D. Forman-Kay University of Toronto
Frank Sicheri
Frank Sicheri Lunenfeld-Tanenbaum Research Institute
Joseph Schlessinger
Joseph Schlessinger Yale University
Aleixo M. Muise
Aleixo M. Muise University of Toronto
Nils Brose
Nils Brose Max Planck Society
Jeffrey L. Wrana
Jeffrey L. Wrana Lunenfeld-Tanenbaum Research Institute
Stephen S. Tobe
Stephen S. Tobe University of Toronto
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Jason Moffat
Jason Moffat University of Toronto

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