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Neuroscience

D-Index
74
Citations
21574
World Ranking
2095
National Ranking
997

Overview

Christian J. Pike is a researcher affiliated with the University of Southern California in the United States. Their work spans multiple disciplines primarily within medicine and neuroscience, with significant contributions to endocrinology, diabetes and metabolism, physiology, neurology, genetics, and pulmonary and respiratory medicine.

The scientist's main research topics include:

  • Alzheimer's disease research and treatments
  • Estrogen and related hormone effects
  • Neuroinflammation and neurodegeneration mechanisms
  • Menopause: health impacts and treatments
  • Nuclear receptors and signaling
  • Dementia and cognitive impairment research
  • Neurological disease mechanisms and treatments

Christian J. Pike has published extensively, with key recent papers including:

  • Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models, 2022, Cell Reports
  • Role of estrogen in women's Alzheimer's disease risk as modified by APOE , 2022, Journal of Neuroendocrinology
  • Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice, 2020, Frontiers in Aging Neuroscience
  • Microglial transcription profiles in mouse and human are driven by APOE4 and sex, 2021, iScience
  • Staining and Quantification of β-Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease, 2020, Methods in molecular biology

The frequent co-authors who have worked collaboratively with Pike include:

  • Amy Christensen
  • Caleb E. Finch
  • Max A. Thorwald
  • Cassandra McGill
  • Bérénice A. Benayoun

Publication venues where Pike has contributed frequently are:

  • Alzheimer s & Dementia
  • Stroke
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Innovation in Aging
  • Frontiers in Aging Neuroscience

Best Publications

  • Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

    Christian J. Pike;Debra Burdick;Andrea J. Walencewicz;Charles G. Glabe

  • Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

    Deryk T. Loo;Agata Copani;Christian J. Pike;Edward R. Whittemore

  • In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity ☆

    Christian J. Pike;Andrea J. Walencewicz;Charles G. Glabe;Carl W. Cotman

  • Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

    Christian J. Pike;Andrea J. Walencewicz-Wasserman;Joseph Kosmoski;David H. Cribbs

  • Progesterone Receptors: Form and Function in Brain

    Roberta Diaz Brinton;Richard F. Thompson;Michael R. Foy;Michel Baudry

  • Protective actions of sex steroid hormones in Alzheimer's disease.

    Christian J. Pike;Jenna C. Carroll;Emily R. Rosario;Anna M. Barron

  • Estrogen Modulates Neuronal Bcl-xl Expression and β-Amyloid-Induced Apoptosis: Relevance to Alzheimer’s Disease

    Christian J. Pike

  • Thrombin Induces Apoptosis in Cultured Neurons and Astrocytes via a Pathway Requiring Tyrosine Kinase and RhoA Activities

    Frances M. Donovan;Christian J. Pike;Carl W. Cotman;Dennis D. Cunningham

  • Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus.

    Nicole C. Berchtold;J. Patrick Kesslak;Christian J. Pike;Paul A. Adlard

  • Sex and the development of Alzheimer's disease.

    Christian J. Pike

  • Progesterone and Estrogen Regulate Alzheimer-Like Neuropathology in Female 3xTg-AD Mice

    Jenna C. Carroll;Emily R. Rosario;Lilly Chang;Frank Z. Stanczyk

  • Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

    Christian J. Pike;Andrea J. Walencewicz;Charles G. Glabe;Carl W. Cotman

  • β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease

    Brian J. Cummings;Brian J. Cummings;Christian J. Pike;Rodman Shankle;Carl W. Cotman

  • Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults

    PJ Vaughan;CJ Pike;CW Cotman;DD Cunningham

  • Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease

    Emily R. Rosario;Lilly Chang;Elizabeth H. Head;Frank Z. Stanczyk

  • Sex differences in β-amyloid accumulation in 3xTg-AD mice: Role of neonatal sex steroid hormone exposure

    Jenna C. Carroll;Emily R. Rosario;Sara Kreimer;Angela Villamagna

  • Rapid Communication: Ca2+ Channel Blockers Attenuate β‐Amyloid Peptide Toxicity to Cortical Neurons in Culture

    John H. Weiss;Christian J. Pike;Carl W. Cotman

  • β-Amyloid-Induced Neuronal Apoptosis Involves c-Jun N-Terminal Kinase-Dependent Downregulation of Bcl-w

    Mingzhong Yao;Thuy-Vi V Nguyen;Christian J Pike

  • Gender, sex steroid hormones, and Alzheimer's disease

    Rebekah S. Vest;Christian J. Pike

  • Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons

    Christian J Pike

Frequent Co-Authors

Carl W. Cotman
Carl W. Cotman University of California, Irvine
Roberta Diaz Brinton
Roberta Diaz Brinton University of Arizona
Margaret Gatz
Margaret Gatz University of Southern California
Salvatore Oddo
Salvatore Oddo Arizona State University
Luis M. Garcia-Segura
Luis M. Garcia-Segura Spanish National Research Council
Michel Baudry
Michel Baudry Western University of Health Sciences
Chandra A. Reynolds
Chandra A. Reynolds University of California, Riverside
Agata Copani
Agata Copani University of Catania
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
John H. Weiss
John H. Weiss University of California, Irvine

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