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Hiroaki Wake

Hiroaki Wake

D-Index & Metrics

Neuroscience

D-Index
37
Citations
12750
World Ranking
8658
National Ranking
311

Overview

Hiroaki Wake is affiliated with Kobe University in Japan and has conducted research spanning multiple areas within neuroscience and molecular biology. Their work notably includes studies on neuroinflammation, neurodegeneration mechanisms, neurogenesis, and immune cell function in cancer.

Their notable recent publications include:

  • Microglia states and nomenclature: A field at its crossroads (2022, Neuron)
  • Negative feedback control of neuronal activity by microglia (2020, Nature)
  • Maternal immune activation induces sustained changes in fetal microglia motility (2020, Scientific Reports)
  • YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation (2020, Nature Communications)
  • Pain induces stable, active microcircuits in the somatosensory cortex that provide a therapeutic target (2021, Science Advances)

Frequent coauthors in their research include:

  • Daisuke Kato
  • Takahiro Tsuji
  • Mariko Shindo
  • Shouta Sugio
  • Hiroaki Ozasa

The main venues where Wake has published are:

  • Cancer Research
  • Scientific Reports
  • SSRN Electronic Journal
  • Neuroscience Research
  • PubMed

Wake's research spans the following main fields of study:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, their work often focusses on subfields such as:

  • Neurology
  • Cellular and Molecular Neuroscience
  • Immunology
  • Developmental Neuroscience
  • Molecular Biology

The major research topics covered by their publications include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neurogenesis and neuroplasticity mechanisms
  • Immune cells in cancer
  • Neuroscience and Neuropharmacology Research
  • Nerve injury and regeneration
  • Lipid metabolism and biosynthesis
  • Advanced Fluorescence Microscopy Techniques

In addition to articles, Hiroaki Wake has contributed to book publications. One such example is a 2024 title published by Frontiers Media, titled Oligodendrocytes: From Their Development to Function and Dysfunction.

Best Publications

  • Microglia states and nomenclature: A field at its crossroads

    Unknown

  • Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

    Hiroaki Wake;Andrew J. Moorhouse;Andrew J. Moorhouse;Shozo Jinno;Shinichi Kohsaka

  • The Role of Microglia in the Healthy Brain

    Marie-Ève Tremblay;Beth Stevens;Amanda Sierra;Hiroaki Wake

  • Negative feedback control of neuronal activity by microglia

    Ana Badimon;Hayley J. Strasburger;Pinar Ayata;Xinhong Chen

  • Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.

    Koichiro Haruwaka;Koichiro Haruwaka;Ako Ikegami;Yoshihisa Tachibana;Nobuhiko Ohno

  • Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

    Hiroaki Wake;Philip R. Lee;R. Douglas Fields

  • Microglia contact induces synapse formation in developing somatosensory cortex.

    Akiko Miyamoto;Hiroaki Wake;Ayako Wendy Ishikawa;Kei Eto;Kei Eto

  • Microglia: actively surveying and shaping neuronal circuit structure and function

    Hiroaki Wake;Andrew J. Moorhouse;Akiko Miyamoto;Junichi Nabekura

  • Nonsynaptic junctions on myelinating glia promote preferential myelination of electrically active axons

    Hiroaki Wake;Fernando C. Ortiz;Dong Ho Woo;Philip R. Lee

  • Glial Biology in Learning and Cognition

    R. Douglas Fields;Alfonso Araque;Heidi Johansen-Berg;Soo Siang Lim

  • Regulation of myelin structure and conduction velocity by perinodal astrocytes

    Dipankar J. Dutta;Dipankar J. Dutta;Dong Ho Woo;Philip R. Lee;Sinisa Pajevic

  • Early Changes in KCC2 Phosphorylation in Response to Neuronal Stress Result in Functional Downregulation

    Hiroaki Wake;Miho Watanabe;Andrew J. Moorhouse;Takashi Kanematsu

  • Functions of microglia in the central nervous system--beyond the immune response.

    Hiroaki Wake;Andrew J. Moorhouse;Junichi Nabekura

  • Microglia Enhance Synapse Activity to Promote Local Network Synchronization.

    Ryohei Akiyoshi;Hiroaki Wake;Daisuke Kato;Daisuke Kato;Hiroshi Horiuchi

  • Inter-regional Contribution of Enhanced Activity of the Primary Somatosensory Cortex to the Anterior Cingulate Cortex Accelerates Chronic Pain Behavior

    Kei Eto;Hiroaki Wake;Miho Watanabe;Hitoshi Ishibashi

  • Microglia and synapse interactions: fine tuning neural circuits and candidate molecules

    Akiko Miyamoto;Hiroaki Wake;Andrew J Moorhouse;Junichi Nabekura

  • Reduced Mastication Impairs Memory Function.

    Y Fukushima-Nakayama;Takehito Ono;M Hayashi;M Inoue

  • Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity.

    Go Kato;Hiroyuki Inada;Hiroaki Wake;Ryohei Akiyoshi

  • Clustering of Neuronal K+-Cl− Cotransporters in Lipid Rafts by Tyrosine Phosphorylation

    Miho Watanabe;Hiroaki Wake;Andrew J. Moorhouse;Junichi Nabekura;Junichi Nabekura

  • Maternal immune activation induces sustained changes in fetal microglia motility.

    Kana Ozaki;Daisuke Kato;Daisuke Kato;Ako Ikegami;Akari Hashimoto;Akari Hashimoto

  • Never-resting microglia: physiological roles in the healthy brain and pathological implications

    Amanda Sierra;Marie-Ève Tremblay;Hiroaki Wake

  • Sensory Input Regulates Spatial and Subtype-Specific Patterns of Neuronal Turnover in the Adult Olfactory Bulb

    Masato Sawada;Naoko Kaneko;Hiroyuki Inada;Hiroaki Wake

Frequent Co-Authors

Junichi Nabekura
Junichi Nabekura National Institutes of Natural Sciences
R. Douglas Fields
R. Douglas Fields National Institutes of Health
Yuchio Yanagawa
Yuchio Yanagawa Gunma University
Noriyuki Matsukawa
Noriyuki Matsukawa Nagoya City University
Beth Stevens
Beth Stevens Boston Children's Hospital
Marie-Ève Tremblay
Marie-Ève Tremblay University of Victoria
Mami Noda
Mami Noda Kyushu University
Amanda Sierra
Amanda Sierra University of the Basque Country
Shinichi Kohsaka
Shinichi Kohsaka Keio University
Heidi Johansen-Berg
Heidi Johansen-Berg University of Oxford

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