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Neuroscience

D-Index
40
Citations
7085
World Ranking
8054
National Ranking
602

Overview

David A. Lyons is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily focuses on neuroscience, with significant contributions to biochemistry, genetics, and molecular biology. The scientist's work covers a wide range of subfields including developmental neuroscience, molecular biology, cell biology, neurology, and cellular and molecular neuroscience.

The main topics addressed in their research encompass neurogenesis and neuroplasticity mechanisms, applications of zebrafish in biomedical research, neuroinflammation and neurodegeneration mechanisms, RNA research and splicing, neuroscience and neuropharmacology research, microRNA in disease regulation, and RNA interference and gene delivery.

Their recent publications demonstrate engagement with central themes in neurobiology and regenerative processes. Selected papers include:

  • Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin (2020, Seminars in Cell and Developmental Biology)
  • New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination (2022, Nature Neuroscience)
  • Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis (2020, Acta Neuropathologica)
  • Calcium Signaling in the Oligodendrocyte Lineage: Regulators and Consequences (2020, Annual Review of Neuroscience)
  • TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice (2021, Nature Communications)

Frequent co-authors in their work include Rafael Almeida, Jason J. Early, Marcus Keatinge, Megan Madden, and Matthew R. Livesey, indicating collaboration within the neuroscience research community.

Their publications often appear in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Nature Communications, Journal of Neuroscience, and Nature Neuroscience. These venues suggest a focus both on preprint dissemination and peer-reviewed biomedical literature.

Best Publications

  • Glia as architects of central nervous system formation and function

    Nicola J. Allen;David A. Lyons

  • Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

    Nicolas Snaidero;Wiebke Möbius;Tim Czopka;Liesbeth H.P. Hekking

  • Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo

    Sigrid Mensch;Marion Baraban;Rafael Almeida;Tim Czopka;Tim Czopka

  • erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.

    David A. Lyons;Hans-Martin Pogoda;Matthew G. Voas;Ian G. Woods

  • Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo

    Tim Czopka;Charles ffrench-Constant;David A. Lyons

  • Individual axons regulate the myelinating potential of single oligodendrocytes in vivo

    Rafael G. Almeida;Tim Czopka;Charles ffrench-Constant;David A. Lyons

  • A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis

    Unknown

  • On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function.

    Rafael G. Almeida;David A. Lyons

  • Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.

    David A Lyons;Stephen G Naylor;Anja Scholze;William S Talbot

  • Ca 2+ activity signatures of myelin sheath formation and growth in vivo.

    Marion Baraban;Sigrid Koudelka;David A Lyons

  • Myelin Dynamics Throughout Life: An Ever-Changing Landscape?

    Jill M Williamson;David A Lyons

  • Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release

    Sigrid Koudelka;Matthew G. Voas;Rafael G. Almeida;Marion Baraban

  • Glial Cell Development and Function in Zebrafish

    David A. Lyons;William S. Talbot

  • Revisiting remyelination: Towards a consensus on the regeneration of CNS myelin.

    Robin J.M. Franklin;Jonas Frisén;David A. Lyons

  • A genetic screen identifies genes essential for development of myelinated axons in zebrafish.

    Hans-Martin Pogoda;Nitzan Sternheim;David A. Lyons;Brianne Diamond

  • Axonal selection and myelin sheath generation in the central nervous system.

    Mikael Simons;David A Lyons

  • Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain

    David A Lyons;Adam T Guy;Jonathan D W Clarke

  • Myelinated axon physiology and regulation of neural circuit function.

    Daumante Suminaite;David A. Lyons;Matthew R. Livesey

  • Somatodendritic Expression of JAM2 Inhibits Oligodendrocyte Myelination

    Stephanie A. Redmond;Feng Mei;Yael Eshed-Eisenbach;Lindsay A. Osso

  • alphaII-spectrin is essential for assembly of the nodes of Ranvier in myelinated axons

    Matthew G. Voas;David A. Lyons;Stephen G. Naylor;Naomi Arana

  • KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome

    David A. Lyons;Stephen G. Naylor;Sara Mercurio;Claudia Dominguez

  • An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination.

    Jason J Early;Katy Lh Cole;Jill M Williamson;Matthew Swire

  • New oligodendrocytes exhibit more abundant and accurate myelin regeneration than those that survive demyelination

    Sarah A Neely;Jill M Williamson;Anna Klingseisen;Lida Zoupi

Frequent Co-Authors

Jonah R. Chan
Jonah R. Chan University of California, San Francisco
Thomas Becker
Thomas Becker University of Edinburgh
Peter J. Brophy
Peter J. Brophy University of Edinburgh
Patrizia Casaccia
Patrizia Casaccia City University of New York
Marc A. T. Muskavitch
Marc A. T. Muskavitch Biogen (United States)
Yong-hui Jiang
Yong-hui Jiang Yale School of Medicine
Chao Zhao
Chao Zhao University of Cambridge
Kishan Dholakia
Kishan Dholakia University of St Andrews
Andreas Janshoff
Andreas Janshoff University of Göttingen

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