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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
146
Citations
100718
World Ranking
94
National Ranking
59

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2015 - Fellow of the American Academy of Arts and Sciences
  • 2014 - Member of the National Academy of Sciences
  • 2005 - Member of the National Academy of Medicine (NAM)

Overview

Frank McCormick is affiliated with the University of California, San Francisco in the United States. Their research predominantly focuses on biochemistry, genetics, and molecular biology, with a significant number of publications related to medicine. Within these broader fields, their work emphasizes molecular biology, cell biology, oncology, neurology, and cancer research.

The scientist's recent scholarly output includes several papers published in prominent journals during 2020 and 2021. These papers cover various aspects of RAS biology and cancer metabolism. Notable recent publications include:

  • RAS-targeted therapies: is the undruggable drugged? (2020, Nature Reviews Drug Discovery)
  • The metabolic landscape of RAS-driven cancers from biology to therapy (2021, Nature Cancer)
  • Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers (2020, Cancer Research)
  • ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications (2020, Scientific Reports)
  • KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation (2021, Nature Communications)

McCormick frequently collaborates with several authors, indicating a broad research network. Co-authors with whom they have most frequently published include Dwight V. Nissley, Dominic Esposito, Dhirendra K. Simanshu, Andrew G. Stephen, and Anna Maciąg.

The scientist's work is regularly published in several key venues. The most common publication platforms are:

  • Cancer Research
  • Molecular Cancer Research
  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Biological Chemistry

Key topics underpinning their research are centered on the regulation and signaling of protein kinases and GTPases, melanoma and MAPK pathways, protein tyrosine phosphatases, cancer, hypoxia, and metabolism, ubiquitin and proteasome pathways, neurofibromatosis and schwannoma cases, and broader cancer-related molecular pathways.

Recognition of McCormick's contributions includes several prestigious memberships and honors: they were elected Fellow of the American Academy of Arts and Sciences in 2015, became a Member of the National Academy of Sciences in 2014, and joined the National Academy of Medicine in 2005.

Best Publications

  • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

    Osamu Tetsu;Frank McCormick

  • The GTPase superfamily: conserved structure and molecular mechanism

    Henry R. Bourne;David A. Sanders;Frank McCormick

  • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

    Richard M. Neve;Richard M. Neve;Koei Chin;Jane Fridlyand;Jennifer Yeh

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Francisco Sanchez-Vega;Marco Mina;Joshua Armenia;Walid K. Chatila

  • The GTPase superfamily: a conserved switch for diverse cell functions

    Henry R. Bourne;David A. Sanders;David A. Sanders;Frank McCormick

  • Proteins regulating Ras and its relatives.

    Mark S. Boguski;Frank McCormick

  • An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.

    James R. Bischoff;David H. Kirn;Angelica Williams;Carla Heise

  • The RB and p53 pathways in cancer

    Charles J Sherr;Frank McCormick

  • Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

    David Stokoe;Leonard R. Stephens;Terry Copeland;Piers R. J. Gaffney

  • RAS Proteins and Their Regulators in Human Disease.

    Dhirendra K. Simanshu;Dwight V. Nissley;Frank McCormick;Frank McCormick

  • A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

    Meg Trahey;Frank McCormick

  • Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

    Len Stephens;Karen Anderson;David Stokoe;Hediye Erdjument-Bromage

  • Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

    Matthew J. Hangauer;Vasanthi S. Viswanathan;Matthew J. Ryan;Dhruv Bole

  • Two G protein oncogenes in human endocrine tumors

    John Lyons;Claudia A. Landis;Claudia A. Landis;Griffith Harsh;Lucia Vallar

  • ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

    C Heise;A Sampson-Johannes;A Williams;F McCormick

  • Inhibition by cAMP of Ras-dependent activation of Raf

    Simon J. Cook;Frank McCormick

  • The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

    George A. Martin;David Viskoohil;Gideon Bollag;Peter C. McCabe

  • An essential role for Rac in Ras transformation

    Rong-Guo Qiu;Jing Chen;David Kirn;Frank McCormick

  • Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

    Luika A. Timmerman;Joaquín Grego-Bessa;Angel Raya;Esther Bertrán

  • Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

    Marc Symons;Jonathan M.J Derry;Brian Karlak;Sharon Jiang

Frequent Co-Authors

David M. Jablons
David M. Jablons University of California, San Francisco
Kevan M. Shokat
Kevan M. Shokat University of California, San Francisco
Katherine A. Rauen
Katherine A. Rauen University of California, Davis
Stuart L. Schreiber
Stuart L. Schreiber Harvard University
Joe W. Gray
Joe W. Gray Oregon Health & Science University
David Stokoe
David Stokoe Genentech
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Simon J. Cook
Simon J. Cook Babraham Institute
Julien Mazieres
Julien Mazieres Paul Sabatier University
David W. Eisele
David W. Eisele Johns Hopkins University

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