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Medicine

D-Index
82
Citations
23757
World Ranking
16161
National Ranking
8131

Overview

Kevin Shannon is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology and Cardiology and Cardiovascular Medicine as prominent subfields.

The scientist has contributed extensively to diverse topics including:

  • Cardiac Arrhythmias and Treatments
  • Congenital Heart Disease Studies
  • Cardiac pacing and defibrillation studies
  • Acute Myeloid Leukemia Research
  • Protein Kinase Regulation and GTPase Signaling
  • Protein Degradation and Inhibitors
  • PI3K/AKT/mTOR signaling in cancer

Kevin Shannon's recent publications cover a range of biomedical and clinical research domains. Notable papers include:

  • "RASA2 ablation in T cells boosts antigen sensitivity and long-term function" (2022), published in Nature
  • "ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth" (2021), published in Nature Chemical Biology
  • "MEK inhibitors for neurofibromatosis type 1 manifestations: Clinical evidence and consensus" (2022), published in Neuro-Oncology
  • "Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study" (2020), published in Heart Rhythm
  • "Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia" (2020), published in Leukemia

The scientist has collaborated frequently with colleagues including Benjamin J. Huang, Jeremy P. Moore, Jasmine C. Wong, Scott C. Kogan, and Benjamin F. Cravatt.

Kevin Shannon's work has appeared repeatedly in key academic journals, with frequent publications in:

  • Blood
  • Heart Rhythm
  • JACC. Clinical electrophysiology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cancer Research

The research contributions span molecular biology mechanisms and practical clinical applications particularly in cardiology and oncology, reflecting a multidisciplinary approach. The investigator's scientific output highlights intersections between cellular signaling pathways and disease-oriented clinical treatments and diagnostics.

Best Publications

  • Hyperactive Ras in developmental disorders and cancer.

    Suzanne Schubbert;Kevin Shannon;Gideon Bollag

  • Germline KRAS mutations cause Noonan syndrome

    Suzanne Schubbert;Martin Zenker;Sara L . Rowe;Silke Böll

  • The Rate of Telomere Sequence Loss in Human Leukocytes Varies with Age

    Robert W. Frenck;Elizabeth H. Blackburn;Kevin M. Shannon

  • Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

    G. Bollag;D. W. Clapp;S. Shih;F. Adler

  • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

    Kevin M Haigis;Krystle R Kendall;Yufang Wang;Ann Cheung

  • Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

    Kevin M. Shannon;Peter O'Connell;George A. Martin;Dorothy Paderanga

  • Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

    Mignon L. Loh;Shashaank Vattikuti;Suzanne Schubbert;Melissa G. Reynolds

  • Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birth weight preterm infants.

    K M Shannon;J F Keith rd;W C Mentzer;R A Ehrenkranz

  • Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.

    Benjamin S. Braun;David A. Tuveson;Namie Kong;Doan T. Le

  • Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

    Mignon L. Loh;Debbie S. Sakai;Christian Flotho;Michelle Kang

  • Outcomes in CCG-2961, a Children's Oncology Group Phase 3 Trial for untreated pediatric acute myeloid leukemia: a report from the Children's Oncology Group

    Beverly J. Lange;Franklin O. Smith;James Feusner;Dorothy R. Barnard

  • Homozygous Inactivation of the NF1 Gene in Bone Marrow Cells from Children with Neurofibromatosis Type 1 and Malignant Myeloid Disorders

    Lucy Side;Brigit Taylor;Matthew Cayouette;Edward Conner

  • MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.

    Chong Chen;Yu KiKi Liu;Amy R Rappaport;Thomas Kitzing

  • GTPase activating proteins: critical regulators of intracellular signaling.

    Shane Donovan;Kevin M. Shannon;Gideon Bollag

  • Childhood Monosomy 7: Epidemiology, Biology, and Mechanistic Implications

    S Luna-Fineman;KM Shannon;BJ Lange

  • Single Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

    Nikesh Kotecha;Nikki J. Flores;Jonathan M. Irish;Erin F. Simonds

  • Prevention of Sudden Cardiac Death With Implantable Cardioverter-Defibrillators in Children and Adolescents With Hypertrophic Cardiomyopathy

    Barry J. Maron;Paolo Spirito;Michael J. Ackerman;Susan A. Casey

  • Myelodysplastic and Myeloproliferative Disorders of Childhood: A Study of 167 Patients

    Sandra Luna-Fineman;Kevin M. Shannon;Susan K. Atwater;Jeffrey Davis

  • Targeting oncogenic Ras signaling in hematologic malignancies

    Ashley F. Ward;Benjamin S. Braun;Kevin M. Shannon

  • Erratum: Hyperactive Ras in developmental disorders and cancer

    Suzanne Schubbert;Kevin Shannon;Gideon Bollag

Frequent Co-Authors

Scott C. Kogan
Scott C. Kogan University of California, San Francisco
Mignon L. Loh
Mignon L. Loh University of California, San Francisco
Michelle M. Le Beau
Michelle M. Le Beau University of Chicago
David A. Largaespada
David A. Largaespada University of Minnesota
James R. Downing
James R. Downing St. Jude Children's Research Hospital
Garry P. Nolan
Garry P. Nolan Stanford University
Kalyanam Shivkumar
Kalyanam Shivkumar University of California, Los Angeles
Kevin M. Haigis
Kevin M. Haigis Harvard University
Charlotte M. Niemeyer
Charlotte M. Niemeyer University of Freiburg

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