World's Best Scientists 2026 revealed!
Tyler Jacks

Tyler Jacks

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Best Scientists
2025
Award Badge
Molecular Biology
USA
2026

D-Index & Metrics

Best Scientists

D-Index
178
Citations
155283
World Ranking
641
National Ranking
400

Molecular Biology

D-Index
176
Citations
154239
World Ranking
41
National Ranking
27

Medicine

D-Index
179
Citations
158920
World Ranking
376
National Ranking
238

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2012 - Fellow of the American Academy of Arts and Sciences
  • 2009 - Member of the National Academy of Medicine (NAM)
  • 2009 - Member of the National Academy of Sciences
  • 2005 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center

Overview

Tyler Jacks is affiliated with the Massachusetts Institute of Technology (MIT) in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to subfields including Oncology, Molecular Biology, Immunology, Cancer Research, and Pulmonary and Respiratory Medicine.

Their scholarly work covers a range of topics, notably:

  • Cancer Genomics and Diagnostics
  • Immunotherapy and Immune Responses
  • Single-cell and Spatial Transcriptomics
  • Pancreatic and Hepatic Oncology Research
  • Cancer Immunotherapy and Biomarkers
  • Cancer Cells and Metastasis
  • Immune Cell Function and Interaction

Tyler Jacks has been published extensively across several journals and venues, including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature
  • Regular and Young Investigator Award Abstracts

Recent notable papers include:

  • "Lung adenocarcinoma promotion by air pollutants" (2023, Nature)
  • "Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment" (2022, Nature Genetics)
  • "Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution" (2022, Cell)
  • "Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer" (2021, Cell)
  • "Emergence of a High-Plasticity Cell State during Lung Cancer Evolution" (2020, Cancer Cell)

Frequent collaborators include:

  • Peter M.K. Westcott
  • Alex M. Jaeger
  • William L. Hwang
  • Santiago Naranjo
  • William A. Freed-Pastor

Tyler Jacks has received several recognitions throughout their career, including:

  • Fellow of the American Academy of Arts and Sciences (2012)
  • Member of the National Academy of Sciences (2009)
  • Member of the National Academy of Medicine (2009)
  • Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center (2005)

Best Publications

  • MicroRNA expression profiles classify human cancers

    Jun Lu;Gad Getz;Eric A. Miska;Eric A. Miska;Ezequiel Alvarez-Saavedra

  • Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

    Mitchell Guttman;Ido Amit;Manuel Garber;Courtney French

  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

    Michael B. Kastan;Qimin Zhan;Wafik S. El-Deiry

  • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

    S W Lowe;H E Ruley;T Jacks;D E Housman

  • p53 is required for radiation-induced apoptosis in mouse thymocytes

    Scott W. Lowe;Earlene M. Schmitt;Sallie W. Smith;Barbara A. Osborne

  • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

    David A. Barbie;Pablo Tamayo;Jesse S. Boehm;So Young Kim

  • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

    Thomas G. Graeber;Cynthia Osmanian;Tyler Jacks;David E. Housman

  • Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer

    Carla F. Bender Kim;Erica L. Jackson;Amber E. Woolfenden;Sharon Lawrence

  • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

    Sunil R. Hingorani;Emanuel F. Petricoin;Anirban Maitra;Vinodh Rajapakse

  • Tumor spectrum analysis in p53-mutant mice.

    Tyler Jacks;Lee Remington;Bart O. Williams;Earlene M. Schmitt

  • A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

    Maite Huarte;Mitchell Guttman;Mitchell Guttman;David Feldser;Manuel Garber

  • Effects of an Rb mutation in the mouse

    Tyler Jacks;Amin Fazeli;Earlene M. Schmitt;Roderick T. Bronson

  • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

    Erica L. Jackson;Nicholas Willis;Kim Mercer;Roderick T. Bronson

  • Restoration of p53 function leads to tumour regression in vivo

    Andrea Ventura;David G. Kirsch;David G. Kirsch;Margaret E. McLaughlin;David A. Tuveson

  • Sunburn and p53 in the onset of skin cancer

    Annemarie Ziegler;Alan S. Jonason;David J. Leffellt;Jeffrey A. Simon;Jeffrey A. Simon

  • p53 status and the efficacy of cancer therapy in vivo

    SW Lowe;S Bodis;A McClatchey;L Remington

  • Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters

    Andrea Ventura;Amanda G. Young;Monte M. Winslow;Laura Lintault

  • Impaired microRNA processing enhances cellular transformation and tumorigenesis

    Madhu S. Kumar;Jun Lu;Kim L. Mercer;Todd R. Golub

  • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

    Laura R. Livingstone;Alicia White;Alicia White;Jason Sprouse;Jason Sprouse;Elizabeth Livanos;Elizabeth Livanos

  • Radiation-induced cell cycle arrest compromised by p21 deficiency

    James B Brugarolas;Chitra Chandrasekaran;Jeffrey I. Gordon;David Beach

Frequent Co-Authors

Roderick T. Bronson
Roderick T. Bronson Harvard University
Tuomas Tammela
Tuomas Tammela Memorial Sloan Kettering Cancer Center
David A. Tuveson
David A. Tuveson Cold Spring Harbor Laboratory
Wen Xue
Wen Xue University of Massachusetts Chan Medical School
William C. Hahn
William C. Hahn Dana-Farber Cancer Institute
Aviv Regev
Aviv Regev Genentech
Kevin M. Haigis
Kevin M. Haigis Harvard University
Bart O. Williams
Bart O. Williams Van Andel Institute

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