World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
21230
World Ranking
16432
National Ranking
6796

Overview

Wen Xue is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans multiple disciplines, primarily focusing on Biochemistry, Genetics, and Molecular Biology, with significant contributions to Medicine. Within these fields, their work concentrates on subfields including Molecular Biology, Immunology, Genetics, Cancer Research, and Epidemiology.

Their research topics cover various areas such as CRISPR and Genetic Engineering, Cancer-related molecular mechanisms, Virus-based gene therapy, RNA modifications and cancer, RNA regulation and disease, Reproductive System and Pregnancy, and RNA Interference and Gene Delivery.

Wen Xue has contributed to several recent papers, reflecting an active engagement in cutting-edge genetic and molecular biology research. Some of their noted publications include:

  • Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice, 2021, Nature Communications
  • Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing, 2023, Nature Biotechnology
  • Deletion and replacement of long genomic sequences using prime editing, 2021, Nature Biotechnology
  • A split prime editor with untethered reverse transcriptase and circular RNA template, 2022, Nature Biotechnology
  • Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases, 2020, Theranostics

The frequent co-authors who collaborate with Wen Xue include:

  • Erik J. Sontheimer
  • Ji-Fan Hu
  • Jiuwei Cui
  • Andrew R. Hoffman
  • Donge Tang

Wen Xue's work is regularly published in well-known scientific venues, with frequent appearances in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Nature Biotechnology
  • PubMed

Best Publications

  • A microRNA component of the p53 tumour suppressor network

    Lin He;Xingyue He;Xingyue He;Lee P. Lim;Elisa de Stanchina;Elisa de Stanchina

  • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

    Wen Xue;Lars Zender;Cornelius Miething;Ross A. Dickins;Ross A. Dickins

  • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

    Lars. Zender;Mona S. Spector;Wen. Xue;Peer. Flemming

  • Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype

    Hao Yin;Wen Xue;Sidi Chen;Roman L Bogorad

  • Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

    Hao Yin;Chun-Qing Song;Joseph R. Dorkin;Lihua Julie Zhu

  • CRISPR-mediated direct mutation of cancer genes in the mouse liver

    Wen-Bin Xue;Sidi Chen;Hao Yin;Tuomas Tammela

  • KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

    Diane D. Shao;Wen Xue;Elsa B. Krall;Elsa B. Krall;Arjun Bhutkar

  • An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

    Lars Zender;Wen Xue;Johannes Zuber;Camile P. Semighini

  • Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

    Hao Yin;Chun-Qing Song;Sneha Suresh;Qiongqiong Wu

  • Rapid modelling of cooperating genetic events in cancer through somatic genome editing

    Francisco J. Sánchez-Rivera;Thales Papagiannakopoulos;Rodrigo Romero;Tuomas Tammela

  • Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

    Lu Jiang;Zhao-Hui Gu;Zi-Xun Yan;Xia Zhao

  • Topoisomerase levels determine chemotherapy response in vitro and in vivo

    Darren J. Burgess;Jason Doles;Lars Zender;Wen Xue

  • Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

    Dan Wang;Haiwei Mou;Shaoyong Li;Yingxiang Li

  • p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

    Sung-Hwan Moon;Chun-Hao Huang;Chun-Hao Huang;Chun-Hao Huang;Shauna L. Houlihan;Kausik Regunath

  • A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

    Tuomas Tammela;Francisco J. Sanchez-Rivera;Naniye Malli Cetinbas;Katherine Wu

  • IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.

    Mads Gyrd-Hansen;Maurice Darding;Maria Miasari;Massimo M. Santoro;Massimo M. Santoro

  • Small RNA combination therapy for lung cancer

    Wen Xue;James E. Dahlman;Tuomas Tammela;Omar F. Khan

  • p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.

    Darjus F. Tschaharganeh;Wen Xue;Diego F. Calvisi;Matthias Evert

  • Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.

    Hao Yin;Chun-Qing Song;Sneha Suresh;Suet-Yan Kwan

  • A compact, high-accuracy Cas9 with a dinucleotide PAM for in vivo genome editing

    Alireza Edraki;Aamir Mir;Raed Ibraheim;Ildar Gainetdinov

Frequent Co-Authors

Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Zhiping Weng
Zhiping Weng University of Massachusetts Chan Medical School
Lars Zender
Lars Zender German Cancer Research Center
Erik J. Sontheimer
Erik J. Sontheimer University of Massachusetts Chan Medical School
Guangping Gao
Guangping Gao University of Massachusetts Chan Medical School
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Scot A. Wolfe
Scot A. Wolfe University of Massachusetts Chan Medical School
David R. Liu
David R. Liu Broad Institute

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