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Biology and Biochemistry

D-Index
53
Citations
12374
World Ranking
16025
National Ranking
6650

Overview

Kevin M. Haigis is affiliated with Harvard University in the United States. Their research is primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. The subfields of study include Molecular Biology, Cancer Research, Oncology, Cell Biology, and Pathology and Forensic Medicine.

The scientist's work encompasses several main topics, notably:

  • Protein Kinase Regulation and GTPase Signaling
  • Cancer-related Molecular Pathways
  • PI3K/AKT/mTOR signaling in cancer
  • Colorectal Cancer Treatments and Studies
  • MicroRNA in disease regulation
  • Cancer Genomics and Diagnostics
  • Lung Cancer Treatments and Mutations

Kevin M. Haigis has published extensively, with recent papers including:

  • The origins and genetic interactions of KRAS mutations are allele- and tissue-specific, 2021, Nature Communications
  • The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation, 2021, Science
  • Discovery of a selective inhibitor of doublecortin like kinase 1, 2020, Nature Chemical Biology
  • Classification of KRAS-Activating Mutations and the Implications for Therapeutic Intervention, 2022, Cancer Discovery
  • MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression, 2020, Cancer Discovery

Frequent coauthors of Kevin M. Haigis include:

  • Christian W. Johnson
  • Olesja Popow
  • João A. Paulo
  • Bing Shui
  • Kenneth L. Kehl

Publication venues where the scientist's work frequently appears include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Molecular Cancer Research
  • Cancer Discovery
  • Molecular Cell

Best Publications

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor

    Anne E. Powell;Yang Wang;Yina Li;Emily J. Poulin

  • Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

    Kevin M Haigis;Krystle R Kendall;Yufang Wang;Ann Cheung

  • Regulating the regulator: post-translational modification of RAS

    Ian M. Ahearn;Kevin Haigis;Dafna Bar-Sagi;Mark R. Philips

  • An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background

    Devarati Mitra;Xi Luo;Ann Morgan;Jin Wang

  • Acquired Resistance to KRASG12C Inhibition in Cancer

    Mark M Awad;Shengwu Liu;Igor I Rybkin;Kathryn C Arbour

  • Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer

    Sergio Kaiser;Young Kyu Park;Jeffrey L. Franklin;Richard B. Halberg

  • KRAS Alleles: The Devil Is in the Detail

    Kevin M. Haigis

  • E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

    Erick J. Morris;Jun Yuan Ji;Fajun Yang;Luisa Di Stefano

  • Specific Mutations in KRAS Codons 12 and 13, and Patient Prognosis in 1075 BRAF Wild-Type Colorectal Cancers

    Yu Imamura;Teppei Morikawa;Xiaoyun Liao;Paul Lochhead

  • p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

    David G. Kirsch;Philip M. Santiago;Emmanuelle di Tomaso;Julie M. Sullivan

  • NRAS Mutations Are Rare in Colorectal Cancer

    Natsumi Irahara;Yoshifumi Baba;Katsuhiko Nosho;Kaori Shima

  • Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

    Joseph L. Kissil;Marita J. Walmsley;Linda Hanlon;Kevin M. Haigis

  • K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

    Frederick D. Tsai;Mathew S. Lopes;Mo Zhou;Helen Court

  • Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.

    Qing Li;Kevin M. Haigis;Andrew McDaniel;Emily Harding-Theobald

  • HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS

    Moon Hee Yang;Gaelle Laurent;Alexandra S. Bause;Robert Spang

  • Tissue-specificity in cancer: The rule, not the exception.

    Kevin M. Haigis;Kevin M. Haigis;Karen Cichowski;Karen Cichowski;Stephen J. Elledge

  • Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein

    Alessandra Ianari;Tiziana Natale;Eliezer Calo;Elisabetta Ferretti

  • Tissue-Specific Oncogenic Activity of KRASA146T

    Emily J. Poulin;Emily J. Poulin;Asim K. Bera;Jia Lu;Yi Jang Lin;Yi Jang Lin

  • Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

    Yu Imamura;Paul Lochhead;Paul Lochhead;Mai Yamauchi;Aya Kuchiba

Frequent Co-Authors

Kevin Shannon
Kevin Shannon University of California, San Francisco
Joao A. Paulo
Joao A. Paulo Harvard University
Robert J. Coffey
Robert J. Coffey Vanderbilt University Medical Center
William F. Dove
William F. Dove University of Wisconsin–Madison
Shuji Ogino
Shuji Ogino Brigham and Women's Hospital
Andrew X. Zhu
Andrew X. Zhu Harvard University

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