World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
10622
World Ranking
12733
National Ranking
5428

Overview

Hyunbum Jang is a researcher affiliated with Leidos in the United States, with a primary focus in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Computational Theory and Mathematics, Cell Biology, Oncology, and Genetics. This breadth outlines a comprehensive engagement with biological and computational sciences.

The scientist's publication record includes significant contributions to topics such as Protein Kinase Regulation and GTPase Signaling, Computational Drug Discovery Methods, Melanoma and MAPK Pathways, PI3K/AKT/mTOR signaling in cancer, Protein Degradation and Inhibitors, Protein Structure and Dynamics, and Bioinformatics and Genomic Networks.

Frequent publication venues for their research include bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Journal of Molecular Biology, Biophysical Journal, and The Journal of Physical Chemistry B. These journals cover a wide research spectrum from preprints to specialized fields of molecular and physical chemistry.

Their frequent coauthors are:

  • Ruth Nussinov
  • Mingzhen Zhang
  • Yonglan Liu
  • Chung-Jung Tsai
  • Bengi Ruken Yavuz

Notable recent papers by Hyunbum Jang include:

  • Anticancer drug resistance: An update and perspective, 2021, Drug Resistance Updates
  • PI3K inhibitors: review and new strategies, 2020, Chemical Science
  • AlphaFold, Artificial Intelligence (AI), and Allostery, 2022, The Journal of Physical Chemistry B
  • AlphaFold, allosteric, and orthosteric drug discovery: Ways forward, 2023, Drug Discovery Today
  • The mechanism of activation of monomeric B-Raf V600E, 2021, Computational and Structural Biotechnology Journal

Best Publications

  • Allostery in Its Many Disguises: From Theory to Applications

    Shoshana J. Wodak;Emanuele Paci;Nikolay V. Dokholyan;Nikolay V. Dokholyan;Igor N. Berezovsky

  • Ras Conformational Ensembles, Allostery, and Signaling.

    Shaoyong Lu;Shaoyong Lu;Hyunbum Jang;Serena Muratcioglu;Attila Gursoy

  • Truncated β-amyloid peptide channels provide an alternative mechanism for Alzheimer’s Disease and Down syndrome

    Hyunbum Jang;Fernando Teran Arce;Srinivasan Ramachandran;Ricardo Capone

  • Modeling the Alzheimer Aβ17-42 Fibril Architecture: Tight Intermolecular Sheet-Sheet Association and Intramolecular Hydrated Cavities

    Jie Zheng;Hyunbum Jang;Buyong Ma;Chung-Jun Tsai

  • Models of β-Amyloid Ion Channels in the Membrane Suggest That Channel Formation in the Bilayer Is a Dynamic Process

    Hyunbum Jang;Jie Zheng;Ruth Nussinov;Ruth Nussinov

  • GTP-Dependent K-Ras Dimerization

    Serena Muratcioglu;Tanmay S. Chavan;Benjamin C. Freed;Hyunbum Jang

  • New structures help the modeling of toxic amyloidß ion channels

    Hyunbum Jang;Jie Zheng;Ratnesh Lal;Ruth Nussinov;Ruth Nussinov

  • The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.

    Shaoyong Lu;Hyunbum Jang;Ruth Nussinov;Ruth Nussinov;Jian Zhang;Jian Zhang

  • Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

    Shaoyong Lu;Hyunbum Jang;Shuo Gu;Jian Zhang

  • Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

    M Steklov;S Pandolfi;MF Baietti;A Batiuk

  • Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane.

    Hyunbum Jang;Laura Connelly;Fernando Teran Arce;Srinivasan Ramachandran

  • β-Barrel Topology of Alzheimer's β-Amyloid Ion Channels

    Hyunbum Jang;Fernando Teran Arce;Srinivasan Ramachandran;Ricardo Capone

  • Atomic Force Microscopy and MD Simulations Reveal Pore-Like Structures of All-d-Enantiomer of Alzheimer’s β-Amyloid Peptide: Relevance to the Ion Channel Mechanism of AD Pathology

    Laura Connelly;Hyunbum Jang;Fernando Teran Arce;Ricardo Capone

  • Antimicrobial Protegrin-1 Forms Amyloid-Like Fibrils with Rapid Kinetics Suggesting a Functional Link

    Hyunbum Jang;Fernando Teran Arce;Mirela Mustata;Srinivasan Ramachandran

  • Models of Toxic β-Sheet Channels of Protegrin-1 Suggest a Common Subunit Organization Motif Shared with Toxic Alzheimer β-Amyloid Ion Channels☆

    Hyunbum Jang;Buyong Ma;Ratnesh Lal;Ruth Nussinov;Ruth Nussinov

  • Oncogenic Ras Isoforms Signaling Specificity at the Membrane.

    Ruth Nussinov;Chung-Jung Tsai;Hyunbum Jang

  • PI3K inhibitors: review and new strategies

    Mingzhen Zhang;Hyunbum Jang;Ruth Nussinov

  • Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers.

    Ruth Nussinov;Hyunbum Jang;Chung-Jung Tsai;Feixiong Cheng

  • A New View of Ras Isoforms in Cancers

    Ruth Nussinov;Ruth Nussinov;Chung-Jung Tsai;Mayukh Chakrabarti;Hyunbum Jang

  • GTP-dependent K-Ras dimerization

    Serena Muratcioglu;Tanmay S. Chavan;Benjamin C. Freed;Hyunbum Jang

Frequent Co-Authors

Ruth Nussinov
Ruth Nussinov National Institutes of Health
Chung-Jung Tsai
Chung-Jung Tsai Leidos (United States)
Attila Gursoy
Attila Gursoy Koç University
Ozlem Keskin
Ozlem Keskin Koç University
David Fushman
David Fushman University of Maryland, College Park
Ludwine Messiaen
Ludwine Messiaen University of Alabama at Birmingham
Stephane Heymans
Stephane Heymans Maastricht University
Feixiong Cheng
Feixiong Cheng Case Western Reserve University
David B. Sacks
David B. Sacks National Institutes of Health
Eric Legius
Eric Legius KU Leuven

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