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Chemistry

D-Index
79
Citations
23410
World Ranking
3589
National Ranking
1162

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1997 - Fellow of American Physical Society (APS) Citation For the systematic study of the folding, the stability, and the dynamics of biomolecules, in particular of the role of water, using sophisticated molecular dynamics computations

Overview

Angel E. Garcia is affiliated with Los Alamos National Laboratory in the United States. Their research primarily lies within the field of Biochemistry, Genetics and Molecular Biology, with significant contributions to molecular biology, materials chemistry, cell biology, genetics, and computational theory and mathematics.

The scientist has authored publications covering several main topics, including:

  • Protein Structure and Dynamics
  • Protein Kinase Regulation and GTPase Signaling
  • Receptor Mechanisms and Signaling
  • Lipid Membrane Structure and Behavior
  • Bacterial Genetics and Biotechnology
  • Melanoma and MAPK Pathways
  • Computational Drug Discovery Methods

Recent published papers by Angel E. Garcia include:

  • The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling, 2020, Biophysical Journal
  • Modeling of Peptides with Classical and Novel Machine Learning Force Fields: A Comparison, 2021, The Journal of Physical Chemistry B
  • How Anionic Lipids Affect Spatiotemporal Properties of KRAS4B on Model Membranes, 2020, The Journal of Physical Chemistry B
  • Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD, 2020, Biophysical Journal
  • Characterizing the Folding Transition-State Ensembles in the Energy Landscape of an RNA Tetraloop, 2023, Journal of Chemical Information and Modeling

Angel E. Garcia frequently publishes in the following venues:

  • Biophysical Journal
  • Abstracts with programs - Geological Society of America
  • The Journal of Physical Chemistry B
  • Journal of Chemical Information and Modeling
  • Journal of Chemical Theory and Computation

The scientist has collaborated with several frequent co-authors, including:

  • Chris Neale
  • Van A. Ngo
  • Sumantra Sarkar
  • Timothy Travers
  • César A. López

Angel E. Garcia has published at least one book, titled The Kingdom Began in Puerto Rico, released in 2020 by Fordham University Press eBooks.

In recognition of their work, Angel E. Garcia was awarded Fellow of the American Association for the Advancement of Science (AAAS) in 2017. Previously, in 1997, they were named Fellow of the American Physical Society (APS) with a citation highlighting contributions related to biomolecular folding, stability, and dynamics through molecular dynamics computations.

Best Publications

  • Water Determines the Structure and Dynamics of Proteins

    Marie-Claire Bellissent-Funel;Ali Hassanali;Martina Havenith;Richard Henchman

  • Large-amplitude nonlinear motions in proteins

    Angel E. García

  • Free Energy of Ionic Hydration

    Gerhard Hummer;Lawrence R. Pratt;Angel E. García

  • The pressure dependence of hydrophobic interactions is consistent with the observed pressure denaturation of proteins.

    Gerhard Hummer;Shekhar Garde;Shekhar Garde;Angel E. García;Michael E. Paulaitis

  • An information theory model of hydrophobic interactions.

    Gerhard Hummer;Shekhar Garde;Angel E. Garcia;Andrew Pohorille

  • Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies

    Jessica Nasica-Labouze;Phuong H. Nguyen;Fabio Sterpone;Olivia Berthoumieu

  • Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse

    Margaret S. Cheung;Angel E. García;José N. Onuchic

  • The Alzheimer’s Peptides Aβ40 and 42 Adopt Distinct Conformations in Water: A Combined MD / NMR Study

    Nikolaos G. Sgourakis;Yilin Yan;Scott A. McCallum;Chunyu Wang

  • α-Helical stabilization by side chain shielding of backbone hydrogen bonds

    Angel E. García;Kevin Y. Sanbonmatsu

  • Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes

    Henry D. Herce;Angel E. Garcia

  • Cosolvent Effects on Protein Stability

    Deepak R Canchi;Angel E García

  • Exploring the energy landscape of a ? hairpin in explicit solvent

    Angel E. García;Kevin Y. Sanbonmatsu

  • Hydrophobic Effects on a Molecular Scale

    G. Hummer;S. Garde;A. E. García;M. E. Paulaitis

  • Cavities determine the pressure unfolding of proteins

    Julien Roche;Jose A. Caro;Douglas R. Norberto;Philippe Barthe

  • Folding a protein in a computer: an atomic description of the folding/unfolding of protein A.

    Angel E. García;José N. Onuchic

  • Folding funnels and frustration in off-lattice minimalist protein landscapes

    Hugh Nymeyer;Angel E. García;José Nelson Onuchic

  • Arginine-Rich Peptides Destabilize the Plasma Membrane, Consistent with a Pore Formation Translocation Mechanism of Cell-Penetrating Peptides

    H. D. Herce;A. E. Garcia;J. Litt;R. S. Kane

  • New perspectives on hydrophobic effects

    G. Hummer;S. Garde;A.E. Garcı́a;L.R. Pratt

  • High-resolution reversible folding of hyperstable RNA tetraloops using molecular dynamics simulations

    Alan A. Chen;Angel E. García

  • Structure of Met‐enkephalin in explicit aqueous solution using replica exchange molecular dynamics

    K.Y. Sanbonmatsu;A.E. García

  • Origin of Entropy Convergence in Hydrophobic Hydration and Protein Folding.

    Shekhar Garde;Shekhar Garde;Gerhard Hummer;Angel E. García;Michael E. Paulaitis;Michael E. Paulaitis

Frequent Co-Authors

Gerhard Hummer
Gerhard Hummer Max Planck Society
Lawrence R. Pratt
Lawrence R. Pratt Tulane University
Shekhar Garde
Shekhar Garde Rensselaer Polytechnic Institute
Catherine A. Royer
Catherine A. Royer Rensselaer Polytechnic Institute
José N. Onuchic
José N. Onuchic Rice University
George I. Makhatadze
George I. Makhatadze Rensselaer Polytechnic Institute
Régis Pomès
Régis Pomès University of Toronto
Stephanie Tristram-Nagle
Stephanie Tristram-Nagle Carnegie Mellon University
Jill Trewhella
Jill Trewhella University of Sydney
Robert K. Moyzis
Robert K. Moyzis University of California, Irvine

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