World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
61
Citations
19432
World Ranking
11144
National Ranking
287

Overview

Nelleke A. Gruis is affiliated with Leiden University Medical Center in the Netherlands. Their research focuses on several interconnected fields within medicine and biochemistry, genetics, and molecular biology. The main subfields of study include oncology, immunology, molecular biology, dermatology, and cell biology.

The scientist's work primarily addresses topics such as cutaneous melanoma detection and management, skin protection and aging, melanin and skin pigmentation, cancer genomics and diagnostics, immunotherapy and immune responses, epigenetics and DNA methylation, as well as mast cells and histamine.

Their recent publications span a range of journals and venues. Notable papers include:

  • Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility, 2020, Nature Genetics
  • Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia, 2021, Genetics in Medicine
  • Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression, 2020, PLoS ONE
  • Loss of Wild-Type CDKN2A Is an Early Event in the Development of Melanoma in FAMMM Syndrome, 2020, Journal of Investigative Dermatology
  • Association of HERV-K and LINE-1 Hypomethylation with Reduced Disease-Free Survival in Melanoma Patients, 2020, Epigenomics

These papers reflect a focus on genetic susceptibility to melanoma, epigenetic modifications, and molecular mechanisms underlying melanoma progression.

Their frequent coauthors in research include Remco van Doorn, Susana Puig, Paola Ghiorzo, Maria Concetta Fargnoli, and Veronica Höiom, indicating collaborative efforts within dermatology and genetic research communities.

The scientist frequently publishes in venues such as PLoS ONE, the Journal of the European Academy of Dermatology and Venereology, Nature Genetics, Genetics in Medicine, and the Journal of Investigative Dermatology.

Best Publications

  • A cell cycle regulator potentially involved in genesis of many tumor types

    Alexander Kamb;Nelleke A. Gruis;Jane Weaver-Feldhaus;Qingyun Liu

  • Analysis of the p16 gene (CDKN2) as a candidate· for the chromosome 9p melanoma susceptibility locus

    A. Kamb;D. Shattuck-Eidens;R. Eeles;R. Eeles;Qingyun Liu

  • Geographical Variation in the Penetrance of CDKN2A Mutations for Melanoma

    D. Timothy Bishop;Florence Demenais;Alisa M. Goldstein;Wilma Bergman

  • Genome-wide association study identifies three loci associated with melanoma risk.

    D Timothy Bishop;Florence Demenais;Mark M Iles;Mark Harland

  • Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).

    H.F.A. Vasen;N.A. Gruis;R.R. Frants;P.A. van der Velden

  • Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma‐prone families from three continents

    Alisa M Goldstein;May Chan;Mark Harland;Nicholas K Hayward

  • Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color.

    Cornelis Kennedy;Jeanet ter Huurne;Marjo Berkhout;Nelleke Gruis

  • High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL

    Alisa M. Goldstein;May Chan;Mark Harland;Elizabeth M. Gillanders

  • Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

    Gruis Na;van der Velden Pa;Sandkuijl La;Prins De

  • POT1 loss-of-function variants predispose to familial melanoma

    Carla Daniela Robles-Espinoza;Mark Harland;Andrew J Ramsay;Lauren G Aoude

  • Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls

    Yu Mei Chang;Jennifer H. Barrett;Timothy D. Bishop;Bruce K. Armstrong

  • Melanocortin-1 receptor gene variants determine the risk of nonmelanoma skin cancer independently of fair skin and red hair.

    Maarten T. Bastiaens;Jeannet A. C. ter Huurne;Christine Kielich;Nelleke A. Gruis

  • Genome-wide association study identifies three new melanoma susceptibility loci

    Jennifer H. Barrett;Mark M. Iles;Mark Harland;John C. Taylor

  • INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence.

    Sharon Brookes;Janice Rowe;Margarida Ruas;Susana Llanos

  • A road map for efficient and reliable human genome epidemiology.

    John P A Ioannidis;John P A Ioannidis;Marta Gwinn;Julian Little;Julian P T Higgins

  • The melanocortin-1-receptor gene is the major freckle gene

    Maarten Bastiaens;Jeanette ter Huurne;Nelleke Gruis;Wilma Bergman

  • Common sequence variants on 20q11.22 confer melanoma susceptibility

    Kevin M. Brown;Stuart MacGregor;Grant W. Montgomery;David W. Craig

  • Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS.

    W. Zuidervaart;F. van Nieuwpoort;M. Stark;R. Dijkman

  • Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

    Matthew H. Law;D. Timothy Bishop;Jeffrey E. Lee;Myriam Brossard

  • Melanocortin-1 Receptor Variant R151C Modifies Melanoma Risk in Dutch Families with Melanoma

    Pieter A. van der Velden;Lodewijk A. Sandkuijl;Wilma Bergman;Stan Pavel

Frequent Co-Authors

Nicholas K. Hayward
Nicholas K. Hayward QIMR Berghofer Medical Research Institute
Julia Newton-Bishop
Julia Newton-Bishop University of Leeds
Susana Puig
Susana Puig University of Barcelona
Johan Hansson
Johan Hansson Karolinska Institute
Graham J. Mann
Graham J. Mann Australian National University
D. Timothy Bishop
D. Timothy Bishop University of Leeds
Håkan Olsson
Håkan Olsson Lund University
Maria Teresa Landi
Maria Teresa Landi National Institutes of Health
Rune R. Frants
Rune R. Frants Leiden University
David E. Elder
David E. Elder Hospital of the University of Pennsylvania

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