What is he best known for?
The fields of study he is best known for:
- Gene
- Enzyme
- Cell membrane
John F. Hancock spends much of his time researching Cell biology, Lipid raft, Signal transduction, Caveolae and Membrane.
His Cell biology research includes elements of Plasma membrane organization, Cell membrane and Membrane protein.
Cell membrane is the subject of his research, which falls under Biochemistry.
John F. Hancock interconnects Transport protein, Nanoclusters, Transmembrane domain, Signalling and Lipid microdomain in the investigation of issues within Lipid raft.
His Signal transduction research incorporates themes from Molecular biology, Kinase and Effector.
His Membrane study combines topics in areas such as Protein structure, GTP', Compartmentalization and Förster resonance energy transfer.
His most cited work include:
- All ras proteins are polyisoprenylated but only some are palmitoylated. (1543 citations)
- A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane (917 citations)
- Activation of Raf as a result of recruitment to the plasma membrane (851 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Cell biology, Signal transduction, Membrane, Biochemistry and Cell membrane.
His work is connected to Lipid raft, Caveolae, MAPK/ERK pathway, Caveolin and Effector, as a part of Cell biology.
His studies deal with areas such as Endoplasmic reticulum, Compartmentalization and Lipid microdomain as well as Lipid raft.
His research in Signal transduction intersects with topics in Cancer research, Phosphatidylserine, Protein kinase A and Gene isoform.
The study incorporates disciplines such as Cell, Biophysics and Förster resonance energy transfer in addition to Membrane.
His Cell membrane study integrates concerns from other disciplines, such as Proto-Oncogene Proteins p21 and Membrane protein.
He most often published in these fields:
- Cell biology (60.25%)
- Signal transduction (26.78%)
- Membrane (17.99%)
What were the highlights of his more recent work (between 2015-2021)?
- Cell biology (60.25%)
- Cancer research (13.81%)
- KRAS (11.30%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Cell biology, Cancer research, KRAS, Membrane and Biophysics.
John F. Hancock has researched Cell biology in several fields, including Phosphatidylserine and Epidermal growth factor receptor.
His biological study spans a wide range of topics, including Cancer, Protein kinase B, PI3K/AKT/mTOR pathway and Cell growth.
His studies deal with areas such as Cancer cell, Carcinogenesis, Small GTPase and Function as well as KRAS.
His Membrane research entails a greater understanding of Biochemistry.
His Biophysics study incorporates themes from GTPase, Nanoclusters, Bilayer, Mutant and Prenylation.
Between 2015 and 2021, his most popular works were:
- Inhibition of RAS function through targeting an allosteric regulatory site (157 citations)
- Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output (141 citations)
- Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis. (79 citations)
In his most recent research, the most cited papers focused on:
Biophysics, Cancer research, Effector, Membrane and Cell growth are his primary areas of study.
His Biophysics study combines topics in areas such as Membrane binding, GTP' and Nanoclusters.
As part of the same scientific family, John F. Hancock usually focuses on Nanoclusters, concentrating on Guanosine diphosphate and intersecting with Signal transduction.
Effector is a subfield of Cell biology that John F. Hancock tackles.
His research integrates issues of Nitric oxide and Endocytic recycling in his study of Cell biology.
His Membrane research is classified as research in Biochemistry.
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