World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
11056
World Ranking
14453
National Ranking
6081

Overview

D. Wade Clapp is affiliated with Indiana University in the United States and has contributed extensively to the field of medicine, with a particular focus on neurology and related subfields. Their research portfolio encompasses a broad spectrum of topics, primarily centered around neurofibromatosis, schwannoma, and various forms of tumor diagnosis and treatment.

Clapp's main fields of study include:

  • Medicine

Their specific subfields of research cover:

  • Neurology
  • Epidemiology
  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Rheumatology

The primary topics addressed in their work are:

  • Neurofibromatosis and Schwannoma Cases
  • Meningioma and schwannoma management
  • Neuroblastoma Research and Treatments
  • Sarcoma Diagnosis and Treatment
  • Bone Tumor Diagnosis and Treatments
  • Management of metastatic bone disease
  • Ear and Head Tumors

They have published in several prominent venues, frequently appearing in:

  • Clinical Cancer Research
  • Nature Medicine
  • The Journal of Pediatrics
  • Proceedings of IMPRS
  • UNC Libraries

Frequent coauthors collaborating with Clapp include:

  • Steven P. Angus
  • Steven D. Rhodes
  • Abbi E. Smith
  • Waylan Bessler
  • Dana K. Mitchell

Significant papers by Clapp include:

  • "Selumetinib in Children with Inoperable Plexiform Neurofibromas," 2020, New England Journal of Medicine
  • "Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial," 2021, Nature Medicine
  • "Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK," 2021, PLoS ONE
  • "A molecular basis for neurofibroma-associated skeletal manifestations in NF1," 2020, Genetics in Medicine
  • "Multicenter, prospective, phase II study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular schwannoma," 2023, Neuro-Oncology

Best Publications

  • Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

    Hal E. Broxmeyer;Christie M. Orschell;D. Wade Clapp;Giao Hangoc

  • Selumetinib in Children with Inoperable Plexiform Neurofibromas

    Andrea M. Gross;Pamela L. Wolters;Eva Dombi;Andrea Baldwin

  • Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/−- and c-kit-Dependent Bone Marrow

    Feng Chun Yang;David A. Ingram;Shi Chen;Yuan Zhu

  • Fanconi anaemia and cancer: an intricate relationship.

    Grzegorz Nalepa;D. Wade Clapp

  • Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells

    Feng Chun Yang;David A. Ingram;Shi Chen;Cynthia M. Hingtgen

  • Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo

    Hal E. Broxmeyer;Scott Cooper;Lisa Kohli;Giao Hangoc

  • Fanconi Anemia Proteins Function in Mitophagy and Immunity

    Rhea Sumpter;Shyam Sirasanagandla;Álvaro F. Fernández;Álvaro F. Fernández;Yongjie Wei

  • Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial

    Kent A. Robertson;Grzegorz Nalepa;Feng Chun Yang;Daniel C. Bowers

  • LacZ and Interleukin-3 Expression In Vivo after Retroviral Transduction of Marrow-Derived Human Osteogenic Mesenchymal Progenitors

    James A. Allay;James E. Dennis;Stephen E. Haynesworth;Manas K. Majumdar

  • Genetic and Biochemical Evidence That Haploinsufficiency of the Nf1 Tumor Suppressor Gene Modulates Melanocyte and Mast Cell Fates in Vivo

    David A. Ingram;Feng Chun Yang;Jeffrey B. Travers;Mary Jo Wenning

  • Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells

    Hal E. Broxmeyer;Lisa Kohli;Chang H. Kim;Younghee Lee

  • Multiple Inhibitory Cytokines Induce Deregulated Progenitor Growth and Apoptosis in Hematopoietic Cells From Fac−/− Mice

    Laura S. Haneline;Hal E. Broxmeyer;Scott Cooper;Giao Hangoc

  • Nf1+/− mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling

    Feng Chun Yang;Shi Chen;Travis Clegg;Xiaohong Li

  • Nf1 and Gmcsf interact in myeloid leukemogenesis

    Ron A. Birnbaum;Aengus O'Marcaigh;Zabihullah Wardak;You Yan Zhang

  • Loss of FancC Function Results in Decreased Hematopoietic Stem Cell Repopulating Ability

    Laura S Haneline;Laura S Haneline;Troy A Gobbett;Troy A Gobbett;Rema Ramani;Rema Ramani;Madeleine Carreau;Madeleine Carreau

  • Nf1 Regulates Hematopoietic Progenitor Cell Growth and Ras Signaling in Response to Multiple Cytokines

    You-Yan Zhang;Terry A. Vik;John W. Ryder;Edward F. Srour

  • Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1–haploinsufficient osteoclast functions

    Feng Chun Yang;Shi Chen;Alexander G. Robling;Xijie Yu

  • Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo

    Zhanxiang Wang;Eunjin Oh;D. Wade Clapp;Jonathan Chernoff

  • Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells.

    Kelly K. Hiatt;David A. Ingram;Youyan Zhang;Gideon Bollag

  • p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

    Jayme D. Allen;Zahara M. Jaffer;Su Jung Park;Sarah Burgin

Frequent Co-Authors

Feng Chun Yang
Feng Chun Yang The University of Texas Health Science Center at San Antonio
David A. Ingram
David A. Ingram Indiana University
Helmut Hanenberg
Helmut Hanenberg University of Duisburg-Essen
Hal E. Broxmeyer
Hal E. Broxmeyer Indiana University
Edward F. Srour
Edward F. Srour Indiana University
Kevin Shannon
Kevin Shannon University of California, San Francisco
Luis F. Parada
Luis F. Parada Memorial Sloan Kettering Cancer Center
David A. Williams
David A. Williams Boston Children's Hospital
Jeffrey B. Travers
Jeffrey B. Travers Wright State University
Reuben Kapur
Reuben Kapur Indiana University

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