World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
58
Citations
11662
World Ranking
10646
National Ranking
2938

Biology and Biochemistry

D-Index
61
Citations
11908
World Ranking
11466
National Ranking
4954

Overview

Carole A. Bewley is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with additional contributions in Medicine.

The scientist's work covers several subfields of study, notably Molecular Biology, Pharmacology, Biotechnology, Organic Chemistry, and Spectroscopy. Main research topics include Microbial Natural Products and Biosynthesis, Marine Sponges and Natural Products, Molecular Spectroscopy and Chirality, Genomics and Phylogenetic Studies, Biochemical and Structural Characterization, Carbohydrate Chemistry and Synthesis, and Monoclonal and Polyclonal Antibodies Research.

Frequent publication venues for their work include:

  • Journal of the American Chemical Society
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Angewandte Chemie International Edition
  • Science Advances
  • Angewandte Chemie

Among the recent papers authored or co-authored by Carole A. Bewley are the following:

  • TGF-β uncouples glycolysis and inflammation in macrophages and controls survival during sepsis, 2023, Science Signaling
  • Structural Basis for a Dual Function ATP Grasp Ligase That Installs Single and Bicyclic ω-Ester Macrocycles in a New Multicore RiPP Natural Product, 2021, Journal of the American Chemical Society
  • Properties of Configurationally Stable Atropoenantiomers in Macrocyclic Natural Products and the Chrysophaentin Family, 2023, Accounts of Chemical Research
  • Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge Theonella swinhoei That Inhibit Ras/Raf Interaction, 2020, Journal of Natural Products
  • Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis, 2022, Biology Direct

Carole A. Bewley has collaborated frequently with several researchers including Gengxiang Zhao, Hongbing Liu, Shannon I. Ohlemacher, Robert D. O'Connor, and Rahim Rajwani. The number of joint publications varies, with Gengxiang Zhao being the most frequent co-author.

Best Publications

  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

    Jason S. McLellan;Marie Pancera;Chris Carrico;Jason Gorman

  • Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.

    Chih Chin Huang;Son N. Lam;Priyamvada Acharya;Min Tang

  • The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif.

    J R Huth;C A Bewley;M S Nissen;J N Evans

  • Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G

    Guillaume B.E. Stewart-Jones;Cinque Soto;Thomas Lemmin;Thomas Lemmin;Gwo Yu Chuang

  • Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts.

    C. A. Bewley;N. D. Holland;D. J. Faulkner

  • Minor Groove-Binding Architectural Proteins: Structure, Function, and DNA Recognition

    Carole A. Bewley;and Angela M. Gronenborn;G. Marius Clore

  • Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

    Marie Pancera;Syed Shahzad-Ul-Hussan;Nicole A. Doria-Rose;Jason S. McLellan

  • Solution structure of cyanovirin-N, a potent HIV-inactivating protein

    C A Bewley;K R Gustafson;M R Boyd;D G Covell

  • Lithistid Sponges: Star Performers or Hosts to the Stars.

    Carole A. Bewley;D. John Faulkner

  • Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

    Young Do Kwon;Andrés Finzi;Xueling Wu;Cajetan Dogo-Isonagie

  • DESIGN OF AN EXPRESSION SYSTEM FOR DETECTING FOLDED PROTEIN DOMAINS AND MAPPING MACROMOLECULAR INTERACTIONS BY NMR

    J. R. Huth;C. A. Bewley;B. M. Jackson;A. G. Hinnebusch

  • Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping.

    Fan Yang;Carole A Bewley;John M Louis;Kirk R Gustafson

  • The Potent Anti-HIV Protein Cyanovirin-N Contains Two Novel Carbohydrate Binding Sites That Selectively Bind to Man8 D1D3 and Man9 with Nanomolar Affinity: Implications for Binding to the HIV Envelope Protein gp120

    Carole A. Bewley;Sarah Otero-Quintero

  • Solution Structure of a Cyanovirin-N:Manα1-2Manα Complex

    Carole A Bewley

  • Design of a Novel Peptide Inhibitor of HIV Fusion That Disrupts the Internal Trimeric Coiled-coil of gp41

    Carole A. Bewley;John M. Louis;Rodolfo Ghirlando;G. Marius Clore

  • Mirabamides A-D, depsipeptides from the sponge Siliquariaspongia mirabilis that inhibit HIV-1 fusion.

    Alberto Plaza;Elena Gustchina;Heather L. Baker;Michelle Kelly

  • Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

    Alberto Plaza;Jessica L. Keffer;Giuseppe Bifulco;John R. Lloyd

  • Impact of Residual Dipolar Couplings on the Accuracy of NMR Structures Determined from a Minimal Number of NOE Restraints

    G. Marius Clore;Mary R. Starich;Carole A. Bewley;and Mengli Cai

  • Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry.

    Alberto Plaza;Giuseppe Bifulco;Jessica L. Keffer;John R. Lloyd

  • The Structure of U17 Isolated from Streptomyces clavuligerus and its Properties as an Antioxidant Thiol

    Gerald L. Newton;Carole A. Bewley;Tammy J. Dwyer;Ronda Horn

Frequent Co-Authors

G. Marius Clore
G. Marius Clore National Institutes of Health
Peter D. Kwong
Peter D. Kwong Columbia University Medical Center
John M. Louis
John M. Louis National Institutes of Health
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
D. John Faulkner
D. John Faulkner University of California, San Diego
John R. Mascola
John R. Mascola ModeX Therapeutics
Rodolfo Ghirlando
Rodolfo Ghirlando National Institutes of Health
Giuseppe Bifulco
Giuseppe Bifulco University of Salerno
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Yongping Yang
Yongping Yang National Institutes of Health

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