World's Best Scientists 2026 revealed!
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John M. Louis

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
14465
World Ranking
6081
National Ranking
2861

Chemistry

D-Index
73
Citations
14345
World Ranking
5133
National Ranking
1590

John M. Louis publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where John M. Louis sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 643 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 252 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 244 publications — 48th percentile

48% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

John M. Louis D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where John M. Louis sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 775 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 646 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 73 D-Index — 73rd percentile

73% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Overview

John M. Louis is affiliated with the National Institutes of Health in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with specific focus on molecular biology and infectious diseases.

Their scholarly output encompasses a range of topics, including:

  • Protein Structure and Dynamics
  • SARS-CoV-2 and COVID-19 Research
  • Computational Drug Discovery Methods
  • HIV Research and Treatment
  • RNA and Protein Synthesis Mechanisms
  • Enzyme Structure and Function
  • Advanced NMR Techniques and Applications

Their frequent publication venues include:

  • Communications Biology
  • Proceedings of the National Academy of Sciences
  • Journal of Molecular Biology
  • Biophysical Journal
  • Nature Communications

Recent papers authored or co-authored by John M. Louis highlight research in virology, drug discovery, and protein dynamics. Key publications are:

  • Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease, 2022, Nature Communications
  • Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor, 2022, Communications Biology
  • Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease, 2021, Journal of Medicinal Chemistry
  • Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease, 2020, Proceedings of the National Academy of Sciences
  • Structures of brain-derived 42-residue amyloid-β fibril polymorphs with unusual molecular conformations and intermolecular interactions, 2023, Proceedings of the National Academy of Sciences

John M. Louis collaborates regularly with several researchers, indicating consistent teamwork across multiple studies. Frequent co-authors include:

  • Andrey Kovalevsky
  • Leighton Coates
  • Annie Aniana
  • Rodolfo Ghirlando
  • Nashaat T. Nashed

The main fields of study connected to their work are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broad areas, subfields such as molecular biology, infectious diseases, computational theory and mathematics, virology, and materials chemistry are significant components of their research focus.

Best Publications

  • Single-molecule fluorescence experiments determine protein folding transition path times.

    Hoi Sung Chung;Kevin McHale;John M. Louis;William A. Eaton

  • Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations.

    Kusai A. Merchant;Robert B. Best;John M. Louis;Irina V. Gopich

  • Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function.

    Rieko Ishima;Darón I Freedberg;Yun-Xing Wang;John M Louis

  • A simple apparatus for generating stretched polyacrylamide gels, yielding uniform alignment of proteins and detergent micelles.

    James J. Chou;Sander Gaemers;Bernard Howder;John M. Louis

  • Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories

    Hoi Sung Chung;John M. Louis;William A. Eaton

  • High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.

    Yunfeng Tie;Peter I. Boross;Peter I. Boross;Yuan-Fang Wang;Laquasha Gaddis

  • Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations.

    Darón I. Freedberg;Rieko Ishima;Jaison Jacob;Yun-Xing Wang

  • Autoprocessing of HIV-1 protease is tightly coupled to protein folding.

    Louis Jm;Clore Gm;Gronenborn Am

  • Structure and dynamics of KH domains from FBP bound to single-stranded DNA

    Demetrios T. Braddock;John M. Louis;James L. Baber;David Levens

  • Crystal structure of cyanovirin-N, a potent HIV-inactivating protein, shows unexpected domain swapping.

    Fan Yang;Carole A Bewley;John M Louis;Kirk R Gustafson

  • NMR study of the tetrameric KcsA potassium channel in detergent micelles

    Jordan H. Chill;John M. Louis;Christopher Miller;Ad Bax

  • Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction

    Jim F. White;Justin Grodnitzky;John M. Louis;Loc B. Trinh

  • CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum.

    C L Saxe;G T Ginsburg;J M Louis;R Johnson

  • The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures.

    Laura G. Barrientos;John M. Louis;Istvan Botos;Toshiyuki Mori

  • Design of a Novel Peptide Inhibitor of HIV Fusion That Disrupts the Internal Trimeric Coiled-coil of gp41

    Carole A. Bewley;John M. Louis;Rodolfo Ghirlando;G. Marius Clore

  • The structure of a replication initiator unites diverse aspects of nucleic acid metabolism

    Ramon Campos-Olivas;John M Louis;Danielle Clerot;Bruno Gronenborn

  • The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface

    Justin L. Lorieau;John M. Louis;Ad Bax

  • Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114.

    Andrey Y. Kovalevsky;Fengling Liu;Sofiya Leshchenko;Arun K. Ghosh

  • Structural and kinetic analysis of drug resistant mutants of HIV‐1 protease

    Bhuvaneshwari Mahalingam;John M. Louis;Charles C. Reed;Jill M. Adomat

  • Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main protease

    Unknown

  • Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation.

    E C Murphy;V B Zhurkin;J M Louis;G Cornilescu

Frequent Co-Authors

G. Marius Clore
G. Marius Clore National Institutes of Health
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Ad Bax
Ad Bax National Institutes of Health
Irene T. Weber
Irene T. Weber Georgia State University
Jane M. Sayer
Jane M. Sayer National Institutes of Health
Stephen Oroszlan
Stephen Oroszlan National Institutes of Health
Dennis A. Torchia
Dennis A. Torchia National Institutes of Health
Carole A. Bewley
Carole A. Bewley National Institutes of Health
Rodolfo Ghirlando
Rodolfo Ghirlando National Institutes of Health
Terry D. Copeland
Terry D. Copeland National Institutes of Health

External Links

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Related Online Degrees & Career Pathways

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Together, these related online degrees and career pathways highlight the diverse options available to Chemistry graduates, aligning scientific expertise with in-demand professions.

Best Scientists Citing John M. Louis

Arun K. Ghosh

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Purdue University West Lafayette

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Hiroaki Mitsuya

Hiroaki Mitsuya

Kumamoto University

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G. Marius Clore

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National Institutes of Health

Publications: 65

Irene T. Weber

Irene T. Weber

Georgia State University

Publications: 64

Celia A. Schiffer

Celia A. Schiffer

University of Massachusetts Chan Medical School

Publications: 48

Lewis E. Kay

Lewis E. Kay

University of Toronto

Publications: 46

Benjamin Schuler

Benjamin Schuler

University of Zurich

Publications: 45

Angela M. Gronenborn

Angela M. Gronenborn

University of Pittsburgh

Publications: 45

Robert B. Best

Robert B. Best

National Institutes of Health

Publications: 35

Shibo Jiang

Shibo Jiang

Fudan University

Publications: 34

Ad Bax

Ad Bax

National Institutes of Health

Publications: 31

Jan Konvalinka

Jan Konvalinka

Czech Academy of Sciences

Publications: 28

Alexander S. Arseniev

Alexander S. Arseniev

Russian Academy of Sciences

Publications: 26

Gerhard Hummer

Gerhard Hummer

Max Planck Society

Publications: 26

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National Institutes of Health

Publications: 24

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University of Milan

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