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Chemistry

D-Index
53
Citations
7463
World Ranking
13316
National Ranking
3487

Overview

Jane M. Sayer is a researcher affiliated with the National Institutes of Health in the United States. Their work spans multiple areas within medicine and biochemistry, genetics, and molecular biology, focusing on both physiological and molecular mechanisms.

Their research covers several main fields of study, including:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these broader areas, they have contributed to subfields such as:

  • Physiology
  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Rehabilitation
  • Plant Science

The core topics associated with their work include:

  • Thermoregulation and physiological responses
  • Climate Change and Health Impacts
  • Exercise and Physiological Responses
  • Light effects on plants
  • DNA Repair Mechanisms
  • DNA and Nucleic Acid Chemistry
  • Simulation-Based Education in Healthcare

The researcher has published papers in a variety of venues, with each publication contributing to different aspects of their areas of expertise. Frequent publication outlets include:

  • BMJ Military Health
  • UNC Libraries
  • British Journal of Mental Health Nursing

Representative recent papers include:

  • "Neurological rehabilitation following heat illness in the UK Armed Forces" (2020), published in BMJ Military Health
  • "Inhibition of Werner Syndrome Helicase Activity by Benzo[ c ]phenanthrene Diol Epoxide dA Adducts in DNA Is Both Strand-and Stereoisomer-dependent" (2021), published through UNC Libraries
  • "Enhancing professional identity and professional values in mental health nursing students through simulation-based learning" (2025), published in British Journal of Mental Health Nursing

Jane M. Sayer has collaborated with several co-authors across their research projects, including:

  • Daniel Wilkins
  • Oliver O'Sullivan
  • Lisa Penny
  • Dan Roiz de
  • H Ellis

Best Publications

  • Inhibition of the Mutagenicity of Bay-Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons by Naturally Occurring Plant Phenols: Exceptional Activity of Ellagic Acid

    Alexander W. Wood;Mou-Tuan Huang;Richard L. Chang;Harold L. Newmark

  • Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by phenolic plant flavonoids

    Mou-Tuan Huang;Alexander W. Wood;Harold L. Newmark;Jane.M. Sayer

  • Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

    Stefan G. Sarafianos;Arthur D. Clark;Kalyan Das;Steve Tuske

  • Crystal structure of a benzo[a]pyrene diol epoxide adduct in a ternary complex with a DNA polymerase

    Hong Ling;Jane M. Sayer;Brian S. Plosky;Haruhiko Yagi

  • Extremely facile reaction between the ultimate carcinogen benzo[a]pyrene-7,8-diol 9,10-epoxide and ellagic acid

    Jane M. Sayer;Haruhiko Yagi;Alexander W. Wood;Allan H. Conney

  • Efficiency and accuracy of SOS-induced DNA polymerases replicating benzo[a]pyrene-7,8-diol 9,10-epoxide A and G adducts.

    Xuan Shen;Jane M. Sayer;Heiko Kroth;Ingrid Pontén

  • Optically active benzo[c]phenanthrene diol epoxides bind extensively to adenine in DNA

    A. Dipple;M. A. Pigott;S. K. Agarwal;H. Yagi

  • Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (±)-7β, 8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse

    Richard L. Chang;Mou-Tuan Huang;Alexander W. Wood;Ching-Quo Wong

  • Covalent nucleoside adducts of benzo[a]pyrene 7,8-diol 9,10-epoxides: structural reinvestigation and characterization of a novel adenosine adduct on the ribose moiety

    Jane M. Sayer;Anju Chadha;Shiv K. Agarwal;Herman J. C. Yeh

  • Evidence for two concurrent mechanisms and a kinetically significant proton transfer process in acid-catalyzed O-methyloxime formation

    S. Rosenberg;S. M. Silver;J. M. Sayer;W. P. Jencks

  • Inhibition of the mutagenicity of bay-region diol-epoxides of polycyclic aromatic hydrocarbons by tannic acid, hydroxylated anthraquinones and hydroxylated cinnamic acid derivatives

    Mou-Tuan Huang;Richard L. Chang;Alexander W. Wood;Harold L. Newmark

  • Chemical characterization of DNA adducts derived from the configurationally isomeric benzo(c)phenanthrene 3,4-diol-1,2-epoxides

    Shiv K. Agarwal;Jane M. Sayer;Herman J. C. Yeh;Lewis K. Pannell

  • Covalent Bonding of Bay-Region Diol Epoxides to Nucleic Acids

    Donald M. Jerina;Anju Chadha;Albert M. Cheh;Mark E. Schurdak

  • Human Topoisomerase I Inhibition: Docking Camptothecin and Derivatives into a Structure-Based Active Site Model†

    Gary S Laco;Jack R Collins;Brian T Luke;Heiko Kroth

  • Preferential Misincorporation of Purine Nucleotides by Human DNA Polymerase η Opposite Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Deoxyguanosine Adducts *

    Dominic Chiapperino;Heiko Kroth;Irene H. Kramarczuk;Irene H. Kramarczuk;Jane M. Sayer

  • Disposition of the naturally occurring antimutagenic plant phenol, ellagic acid, and its synthetic derivatives, 3-O-decylellagic acid and 3,3'-di-O-methylellagic acid in mice.

    Robert C. Smart;Mou-Tuan Huang;Richard L. Chang;Jane M. Sayer

  • HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.

    Johnson Agniswamy;Chen-Hsiang Shen;Annie Aniana;Jane M. Sayer

  • Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease

    Jane M. Sayer;Fengling Liu;Rieko Ishima;Irene T. Weber

  • Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

    Stefan G. Sarafianos;Arthur D. Clark;Steve Tuske;Christopher J. Squire

  • Inhibition of autoprocessing of natural variants and multidrug resistant mutant precursors of HIV-1 protease by clinical inhibitors

    John M. Louis;Annie Aniana;Irene T. Weber;Jane M. Sayer

  • Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-purine nucleoside adducts in site-specific mutation studies

    John E. Page;Barbara Zajc;Toshinari Oh-hara;Mahesh K. Lakshman

Frequent Co-Authors

Donald M. Jerina
Donald M. Jerina National Institutes of Health
Haruhiko Yagi
Haruhiko Yagi National Institutes of Health
John M. Louis
John M. Louis National Institutes of Health
Anthony Dipple
Anthony Dipple National Institutes of Health
Allan H. Conney
Allan H. Conney Rutgers, The State University of New Jersey
Yves Pommier
Yves Pommier National Institutes of Health
Irene T. Weber
Irene T. Weber Georgia State University
Paul E. Thomas
Paul E. Thomas Rutgers, The State University of New Jersey
Wayne Levin
Wayne Levin Roche (Switzerland)
Dhiren R. Thakker
Dhiren R. Thakker University of North Carolina at Chapel Hill

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