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Chemistry

D-Index
57
Citations
9223
World Ranking
11343
National Ranking
3076

Overview

Dhiren R. Thakker is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on medicine, with particular attention to infectious diseases, epidemiology, small animal studies, pharmacology, and developmental neuroscience.

Thakker's recent work covers topics such as antifungal resistance and susceptibility, fungal infections, infectious diseases and mycology, medical and biological ozone research, anesthesia and neurotoxicity research, and the effects of nitric oxide and endothelin.

The span of their recent publications includes:

  • Phospholipase C-γ Modulates Epithelial Tight Junction Permeability through Hyperphosphorylation of Tight Junction Proteins (2021, UNC Libraries)
  • Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122 (2020, UNC Libraries)
  • Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding (2020, UNC Libraries)
  • In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3 (2021, UNC Libraries)
  • Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny (2020, UNC Libraries)

Their main coauthors include Ryan R. Klein, Souzan B. Yanni, Daniel K. Benjamin, Patrick Augustijns, and Pieter Annaert. These collaborations have contributed to research in pharmacology and infectious diseases, reflecting interdisciplinary approaches.

Thakker's publications are predominantly featured in the UNC Libraries, indicating a consistent association with academic research within the University of North Carolina system.

Best Publications

  • Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

    M K Buening;P G Wislocki;W Levin;H Yagi

  • Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides

    D. R. Thakker;H. Yagi;A. Y.H. Lu;W. Levin

  • Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides.

    D.R. Thakker;H. Yagi;H. Akagi;M. Koreeda

  • Enhancing paracellular permeability by modulating epithelial tight junctions

    Peter D Ward;Tim K Tippin;Tim K Tippin;Dhiren R Thakker

  • Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium

    Liang Shang L Gan;Dhiren R. Thakker

  • Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides.

    Wood Aw;Chang Rl;Levin W;Yagi H

  • SYNTHESIS AND REACTIONS OF THE HIGHLY MUTAGENIC 7,8‐DIOL 9,10‐EPOXIDES OF THE CARCINOGEN BENZO(A)PYRENE

    H. Yagi;D. R. Thakker;O. Hernandez;M. Koreeda

  • Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.

    Matthew D. Troutman;Dhiren R. Thakker

  • Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporin A transport

    P.F. Augustijns;T.P. Bradshaw;L.S.L. Gan;R.W. Hendren

  • CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.

    L.-S. L. Gan;M. A. Moseley;B. Khosla;P. F. Augustijns

  • Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.

    Matthew D. Troutman;Dhiren R. Thakker

  • Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells.

    Matthew D. Troutman;Dhiren R. Thakker

  • Oxidative Metabolism of Polycyclic Aromatic Hydrocarbons to Ultimate Carcinogens

    Wayne Levin;Alexander Wood;Richard Chang;Dene Ryan

  • Mechanisms underlying saturable intestinal absorption of metformin.

    William R. Proctor;David L. Bourdet;Dhiren R. Thakker

  • Prodrugs of anticancer agents

    Achintya K. Sinhababu;Dhiren R. Thakker

  • Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)

    David L. Bourdet;John B. Pritchard;Dhiren R. Thakker

  • Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers

    Dong Zhou Liu;Edward L. Lecluyse;Dhiren R Thakker

  • Tumorigenicity of Optical Isomers of the Diastereomeric Bay-Region 3,4-Diol-1,2-epoxides of Benzo(c)phenanthrene in Murine Tumor Models

    Wayne Levin;Richard L. Chang;Alexander W. Wood;Dhiren R. Thakker

  • High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism.

    John H. Ansede;Dhiren R. Thakker

  • Metabolism of Chrysene and Phenanthrene to Bay-Region Diol Epoxides by Rat Liver Enzymes

    M Nordqvist;D R Thakker;K P Vyas;H Yagi

  • Additions and Corrections - Synthesis and Reactions of the highly Mutagenic 7,8-Diol 9,10-Epoxides of the Carcinogen Benzo[a]pyrene

    H. Yagi;D. Thakker;O. Hernandez;M. Koreeda

Frequent Co-Authors

Donald M. Jerina
Donald M. Jerina National Institutes of Health
Haruhiko Yagi
Haruhiko Yagi National Institutes of Health
Wayne Levin
Wayne Levin Roche (Switzerland)
Allan H. Conney
Allan H. Conney Rutgers, The State University of New Jersey
Paul E. Thomas
Paul E. Thomas Rutgers, The State University of New Jersey
Dene E. Ryan
Dene E. Ryan Roche (Switzerland)
Kim L. R. Brouwer
Kim L. R. Brouwer University of North Carolina at Chapel Hill
Daniel K. Benjamin
Daniel K. Benjamin Duke University
Jane M. Sayer
Jane M. Sayer National Institutes of Health

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