Paul E. Thomas

Overview

Best Publications

• An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels.

  Paul E. Thomas;Dene Ryan;Wayne Levin

  1574
  Citations

• Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

  D E Ryan;P E Thomas;D Korzeniowski;W Levin

  826
  Citations

• Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.

  C. J. Patten;P. E. Thomas;R. L. Guy;Maojung Lee

  580
  Citations

• Characterization of the Oxidative Metabolites of 17β-Estradiol and Estrone Formed by 15 Selectively Expressed Human Cytochrome P450 Isoforms

  Anthony J. Lee;May Xiaoxin Cai;Paul E. Thomas;Allan H. Conney

  568
  Citations

• Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

  Alexander W. Wood;Dene E. Ryan;Paul E. Thomas;Wayne Levin

  495
  Citations

• Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

  P E Thomas;L M Reik;D E Ryan;W Levin

  482
  Citations

• PCBs: structure-function relationships and mechanism of action.

  Stephen Safe;Stelvio Bandiera;Tom Sawyer;Larry Robertson

  466
  Citations

• Immunochemical Quantitation of Cytochrome P-450 Isozymes and Epoxide Hydrolase in Liver Microsomes from Polychlorinated or Polybrominated Biphenyl-treated Rats A STUDY OF STRUCTURE-ACTIVITY RELATIONSHIPS*

  A Parkinson;S H Safe;L W Robertson;P E Thomas

  440
  Citations

• Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex, and induction.

  P.E. Thomas;L.M. Reik;D.E. Ryan;W. Levin

  437
  Citations

• Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid.

  D E Ryan;L Ramanathan;S Iida;P E Thomas

  429
  Citations

• Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats.

  D E Ryan;S Iida;A W Wood;P E Thomas

  418
  Citations

• Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms.

  D.E. Ryan;P.E. Thomas;W. Levin

  411
  Citations

• Purification, characterization and regulation of five rat hepatic microsomal cytochrome P-450 isozymes

  D. E. Ryan;P. E. Thomas;L. M. Reik;W. Levin

  372
  Citations

• Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448.

  P E Thomas;A Y Lu;D Ryan;S B West

  370
  Citations

• Role of NF-kappaB in regulation of PXR-mediated gene expression: a mechanism for the suppression of cytochrome P-450 3A4 by proinflammatory agents.

  Xinsheng Gu;Sui Ke;Duan Liu;Tao Sheng

  365
  Citations

• Role of nitric oxide in acetaminophen-induced hepatotoxicity in the rat

  Carol R. Gardner;Diane E. Heck;Chung S. Yang;Paul E. Thomas

  328
  Citations

• Methoxyresorufin and benzyloxyresorufin: substrates preferentially metabolized by cytochromes P4501A2 AND 2B, respectively, in the rat and mouse

  Pratibha V. Nerurkar;Sang S. Park;Paul E. Thomas;Raymond W. Nims

  326
  Citations

• Purification of characterization of a minor form of hepatic microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls.

  Dene E. Ryan;Paul E. Thomas;Wayne Levin

  301
  Citations

• Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes.

  Paul E. Thomas;Stelvio Bandiera;Sarah L. Maines;Dene E. Ryan

  288
  Citations

• Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes.

  R. W. Wang;P. H. Kari;A. Y. H. Lu;P. E. Thomas

  279
  Citations