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Medicine

D-Index
74
Citations
18473
World Ranking
19451
National Ranking
9686

Overview

Kim L. R. Brouwer is affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focuses on the field of medicine, with specific emphasis on oncology, epidemiology, pharmacology, pediatrics, perinatology and child health, and hepatology.

The scientist's work covers several core topics including:

  • Drug Transport and Resistance Mechanisms
  • Liver Disease Diagnosis and Treatment
  • Pharmacological Effects and Toxicity Studies
  • Pharmacogenetics and Drug Metabolism
  • Liver Physiology and Pathology
  • Drug-Induced Hepatotoxicity and Protection
  • Pediatric Hepatobiliary Diseases and Treatments

Recent publications authored or co-authored by Kim L. R. Brouwer include:

  • "Membrane transporters in drug development and as determinants of precision medicine," 2024, published in Nature Reviews Drug Discovery
  • "Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium," 2022, Clinical Pharmacology & Therapeutics
  • "Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside," 2020, Pharmacology & Therapeutics
  • "Intestinal P-gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications," 2020, Clinical Pharmacology & Therapeutics
  • "E-Cigarette Flavoring Chemicals Induce Cytotoxicity in HepG2 Cells," 2021, ACS Omega

Frequent co-authors who regularly collaborate with Kim L. R. Brouwer include:

  • Noora Sjöstedt
  • Jacqueline B. Tiley
  • Maciej J. Zamek-Gliszczynski
  • Sibylle Neuhoff
  • John K. Fallon

The scientist has published extensively in reputable venues, including:

  • UNC Libraries
  • Clinical Pharmacology & Therapeutics
  • Drug Metabolism and Pharmacokinetics
  • Toxicological Sciences
  • Journal of Pharmacology and Experimental Therapeutics

Best Publications

  • Membrane transporters in drug development.

    Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet

  • Sandwich-Cultured Hepatocytes: An In Vitro Model to Evaluate Hepatobiliary Transporter-Based Drug Interactions and Hepatotoxicity

    Brandon Swift;Nathan D. Pfeifer;Kim L.R. Brouwer

  • The complexities of hepatic drug transport: current knowledge and emerging concepts.

    Priyamvada Chandra;Kim L. R. Brouwer

  • Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats

    Xingrong Liu;Jack P. Chism;Edward L. LeCluyse;Kenneth R. Brouwer

  • Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

    Maciej J. Zamek-Gliszczynski;Keith A. Hoffmaster;Ken Ichi Nezasa;Melanie N. Tallman

  • Altered Bile Acid Metabolome in Patients with Nonalcoholic Steatohepatitis

    Brian C. Ferslew;Guoxiang Xie;Curtis K. Johnston;Mingming Su

  • Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration.

    Xingrong Liu;Edward L. LeCluyse;Kenneth R. Brouwer;Liang Sheng L. Gan

  • Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation

    Christopher J. Matheny;Matthew W. Lamb;Kim L. R. Brouwer;Gary M. Pollack

  • In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

    K L R Brouwer;D Keppler;K A Hoffmaster;D A J Bow

  • Intracellular Drug Concentrations and Transporters: Measurement, Modeling, and Implications for the Liver

    X. Chu;K. Korzekwa;R. Elsby;K. Fenner

  • Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat.

    Stephen P. Letrent;Gary M. Pollack;Kenneth R. Brouwer;Kim L.R. Brouwer

  • Pharmacokinetics of 5 (and 6)-Carboxy-2′,7′-Dichlorofluorescein and Its Diacetate Promoiety in the Liver

    Maciej J. Zamek-Gliszczynski;Hao Xiong;Nita J. Patel;Ryan Z. Turncliff

  • Use of Ca2+ Modulation to Evaluate Biliary Excretion in Sandwich-Cultured Rat Hepatocytes

    Xingrong Liu;Edward L. LeCluyse;Kenneth R. Brouwer;Kenneth R. Brouwer;Ruth M. Lightfoot;Ruth M. Lightfoot

  • Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group.

    Kim L.R. Brouwer;Lauren M. Aleksunes;Barbara Brandys;George P. Giacoia

  • Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR- rats

    H. Xiong;K. C. Turner;E. S. Ward;P. L.M. Jansen

  • Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.

    Kathleen Köck;Brian C. Ferslew;Ida Netterberg;Kyunghee Yang

  • CHARACTERIZATION OF TRANSPORT PROTEIN EXPRESSION IN MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) 2-DEFICIENT RATS

    Brendan M. Johnson;Peijin Zhang;John D. Schuetz;Kim L. R. Brouwer

  • Increased brain P-glycoprotein in morphine tolerant rats.

    Christina L. Aquilante;Stephen P. Letrent;Gary M. Pollack;Kim L.R. Brouwer

  • Methods to evaluate biliary excretion of drugs in humans: an updated review.

    Giulia Ghibellini;Elaine M Leslie;Kim L R Brouwer

  • Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3- /- and Abcc4- /- mice

    Maciej J. Zamek-Gliszczynski;Ken Ichi Nezasa;Xianbin Tian;Arlene S. Bridges

Frequent Co-Authors

Edward L. LeCluyse
Edward L. LeCluyse Research Triangle Park Foundation
Paul B. Watkins
Paul B. Watkins University of North Carolina at Chapel Hill
Dhiren R. Thakker
Dhiren R. Thakker University of North Carolina at Chapel Hill
Daniel K. Benjamin
Daniel K. Benjamin Duke University
Paavo Honkakoski
Paavo Honkakoski University of Eastern Finland
Richard B. Kim
Richard B. Kim University of Western Ontario
Wei Jia
Wei Jia University of Hong Kong
Angela D. M. Kashuba
Angela D. M. Kashuba University of North Carolina at Chapel Hill
Bruno Stieger
Bruno Stieger University of Zurich
Peter W. Swaan
Peter W. Swaan University of Maryland, Baltimore

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