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Biology and Biochemistry

D-Index
52
Citations
9718
World Ranking
16687
National Ranking
6897

Overview

Adam R. Karpf is affiliated with the University of Nebraska Medical Center in the United States. Their research primarily explores biochemistry, genetics, and molecular biology, with a significant focus on medicine. The work spans several subfields, including molecular biology, cancer research, oncology, immunology, and pulmonary and respiratory medicine.

The scientist has contributed to multiple topics within their fields of study. These include:

  • FOXO transcription factor regulation
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • PARP inhibition in cancer therapy
  • Antimicrobial Peptides and Activities
  • Pancreatic function and diabetes

Recent papers published by Adam R. Karpf cover a range of subjects related to microbial biofilms, cancer, and epigenetic regulation. Some of the notable publications are:

  • Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection, 2020, Nature Microbiology
  • Global DNA hypomethylation in epithelial ovarian cancer: passive demethylation and association with genomic instability, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability, 2020, Cancers
  • FOXM1: A Multifunctional Oncoprotein and Emerging Therapeutic Target in Ovarian Cancer, 2021, Cancers
  • CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models, 2021, Cell Reports Medicine

Adam R. Karpf frequently collaborates with other researchers. Notable coauthors include:

  • David Klinkebiel
  • Cassie Liu
  • Catalina Muñoz-Trujillo
  • Carter J. Barger
  • Ronny Drapkin

The scientist's publications often appear in established journals and venues such as:

  • Cancers
  • Journal of Biological Chemistry
  • Oncogene
  • Cancer Research
  • Nature Microbiology

Best Publications

  • DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

    Kunal Rai;Ian J. Huggins;Smitha R. James;Adam R. Karpf

  • Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

    Pierre-Olivier Estève;Hang Gyeong Chin;Andrea Smallwood;George R. Feehery

  • Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

    Christopher J. Klein;Maria Victoria Botuyan;Yanhong Wu;Christopher J. Ward

  • Reactivating the expression of methylation silenced genes in human cancer.

    Adam R Karpf;David A Jones

  • Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.

    Adam R. Karpf;Sei Ichi Matsui

  • Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry.

    Liguo Song;Smitha R. James;Latif Kazim;Adam R. Karpf

  • Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells.

    Adam R. Karpf;Peter W. Peterson;Joseph T. Rawlins;Brian K. Dalley

  • Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish

    Kunal Rai;Stephanie Chidester;Chad V. Zavala;Elizabeth J. Manos

  • Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection

    Cortney E. Heim;Megan E. Bosch;Megan E. Bosch;Kelsey J. Yamada;Amy L. Aldrich

  • Association between global DNA hypomethylation in leukocytes and risk of breast cancer.

    Ji Yeob Choi;Ji Yeob Choi;Smitha R. James;Petra A. Link;Susan E. Mccann

  • Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-Aza-2′-deoxycytidine

    Adam R. Karpf;Brent C. Moore;Ted O. Ririe;David A. Jones

  • Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer.

    Kunle Odunsi;Junko Matsuzaki;Smitha R. James;Paulette Mhawech-Fauceglia

  • Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.

    Adam R. Karpf;Amy W. Lasek;Ted O. Ririe;Adrianne N. Hanks

  • Superinfection exclusion of alphaviruses in three mosquito cell lines persistently infected with Sindbis virus.

    Adam R. Karpf;Edith Lenches;Ellen G. Strauss;James H. Strauss

  • Pan-cancer analyses reveal genomic features of FOXM1 overexpression in cancer

    Carter J Barger;Connor Branick;Linda Chee;Adam R Karpf

  • Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development.

    Kunal Rai;Lincoln D. Nadauld;Stephanie Chidester;Elizabeth J. Manos

  • Evaluation of a 7-Day Continuous Intravenous Infusion of Decitabine: Inhibition of Promoter-Specific and Global Genomic DNA Methylation

    Wolfram E. Samlowski;Sancy A. Leachman;Mark Wade;Pamela Cassidy

  • Dnmt3 and G9a cooperate for tissue-specific development in zebrafish

    Kunal Rai;Itrat F. Jafri;Stephanie Chidester;Smitha R. James

  • Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability

    Wa Zhang;David Klinkebiel;Carter J Barger;Sanjit Pandey

  • Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy

    Stacey N Akers;Kunle Odunsi;Adam R Karpf

Frequent Co-Authors

Kunle Odunsi
Kunle Odunsi Roswell Park Cancer Institute
David A. Jones
David A. Jones Australian National University
Ronny Drapkin
Ronny Drapkin University of Pennsylvania
Candace S. Johnson
Candace S. Johnson Roswell Park Cancer Institute
Donald L. Trump
Donald L. Trump University of Virginia
Bradley R. Cairns
Bradley R. Cairns University of Utah
James L. Mohler
James L. Mohler Roswell Park Cancer Institute
Lee Zou
Lee Zou Duke University
Dennis Brown
Dennis Brown Harvard University
Kenneth P. Nephew
Kenneth P. Nephew Indiana University

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