Paavo Honkakoski

Overview

Best Publications

• THE NUCLEAR ORPHAN RECEPTOR CAR-RETINOID X RECEPTOR HETERODIMER ACTIVATES THE PHENOBARBITAL-RESPONSIVE ENHANCER MODULE OF THE CYP2B GENE

  Paavo Honkakoski;Igor Zelko;Tatsuya Sueyoshi;Masahiko Negishi

  885
  Citations

• The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene.

  Tatsuya Sueyoshi;Takeshi Kawamoto;Igor Zelko;Paavo Honkakoski

  825
  Citations

• Inhibition and induction of human cytochrome P450 enzymes: current status.

  Olavi Pelkonen;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Jukka Hakkola;Paavo Honkakoski

  683
  Citations

• Regulation of cytochrome P450 (CYP) genes by nuclear receptors

  Paavo Honkakoski;Masahiko Negishi

  629
  Citations

• Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes.

  Marika Ruponen;Seppo Rönkkö;Paavo Honkakoski;Jukka Pelkonen

  262
  Citations

• Drug-activated nuclear receptors CAR and PXR.

  Paavo Honkakoski;Tatsuya Sueyoshi;Masahiko Negishi

  225
  Citations

• ACTIVATION BY DIVERSE XENOCHEMICALS OF THE 51-BASE PAIR PHENOBARBITAL-RESPONSIVE ENHANCER MODULE IN THE CYP2B10 GENE

  Paavo Honkakoski;Rick Moore;Kimberly A. Washburn;Masahiko Negishi

  215
  Citations

• High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans

  Anne-Marie Camus;Olivier Geneste;Paavo Honkakoski;Jean-Claude Béréziat

  206
  Citations

• Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

  Paavo Honkakoski;Masahiko Negishi

  205
  Citations

• Extracellular and intracellular barriers in non-viral gene delivery

  Marika Ruponen;Paavo Honkakoski;Seppo Rönkkö;Jukka Pelkonen

  202
  Citations

• Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse.

  Hannu Raunio;Tuula Syngelmä;Markku Pasanen;Risto Juvonen

  155
  Citations

• Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity

  Kati-Sisko Vellonen;Paavo Honkakoski;Arto Urtti

  149
  Citations

• Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes

  Paavo Honkakoski;Rick Moore;Jukka Gynther;Jukka Gynther;Masahiko Negishi

  138
  Citations

• Cell-surface glycosaminoglycans inhibit cation-mediated gene transfer.

  Marika Ruponen;Paavo Honkakoski;Markku Tammi;Arto Urtti

  135
  Citations

• PEPTIDE-OLIGONUCLEOTIDE PHOSPHOROTHIOATE CONJUGATES WITH MEMBRANE TRANSLOCATION AND NUCLEAR LOCALIZATION PROPERTIES

  Maxim Antopolsky;Elena Azhayeva;Unni Tengvall;Seppo Auriola

  131
  Citations

• Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

  Paavo Honkakoski;Masahiko Negishi

  131
  Citations

• Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

  Masahiko Negishi;Raija Lindberg;Barbara Burkhart;Takeshi Ichikawa

  127
  Citations

• Cocaine N-demethylation and the metabolism-related hepatotoxicity can be prevented by cytochrome P450 3A inhibitors.

  Pertti Pellinen;Paavo Honkakoski;Frej Stenbäck;Matthias Niemitz

  125
  Citations

• Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors.

  Janne Mäkinen;Christian Frank;Johanna Jyrkkärinne;Jukka Gynther

  113
  Citations

• Characterization of human cytochrome P450 induction by pesticides.

  Khaled Abass;Virpi Lämsä;Petri Reponen;Jenni Küblbeck

  109
  Citations