Paavo Honkakoski mainly investigates Biochemistry, Molecular biology, Cytochrome P450, Gene expression and Nuclear receptor. His Molecular biology study combines topics in areas such as Enhancer, Transcription, Messenger RNA and Phenobarbital. Paavo Honkakoski has included themes like Drug metabolism, Microsome, Isozyme, Pharmacology and Cytochrome P450 reductase in his Cytochrome P450 study.
His Gene expression research is multidisciplinary, incorporating elements of Heparan sulfate, Regulation of gene expression, Intracellular and Transfection. His research in the fields of Constitutive androstane receptor and Retinoid X receptor overlaps with other disciplines such as Receptor Cross-Talk. His Constitutive androstane receptor research includes themes of Pregnane X receptor and Nuclear receptor co-repressor 1.
His scientific interests lie mostly in Biochemistry, Cytochrome P450, Molecular biology, Constitutive androstane receptor and Nuclear receptor. Biochemistry connects with themes related to Androstane in his study. The Cytochrome P450 study combines topics in areas such as Enzyme inducer, Drug metabolism, Microsome, Isozyme and Pharmacology.
His research on Molecular biology also deals with topics like
Paavo Honkakoski focuses on Cell biology, Biochemistry, Drug metabolism, Constitutive androstane receptor and Nuclear receptor. His Biochemistry research incorporates elements of Phenacetin and Drug. His biological study spans a wide range of topics, including Regulation of gene expression and Pregnane X receptor.
His Regulation of gene expression research is multidisciplinary, relying on both Cell signaling, Gene expression and Epidermal growth factor receptor. Paavo Honkakoski has researched Pregnane X receptor in several fields, including Drug development, Reverse transfection, Transfection, Molecular biology and Reporter gene. A large part of his Nuclear receptor studies is devoted to Retinoid X receptor.
The scientist’s investigation covers issues in Cell biology, Inflammation, Biochemistry, Retinal pigment epithelium and Cell culture. His Cell biology study integrates concerns from other disciplines, such as Molecular biology and In vitro, Matrigel. His Inflammation research focuses on subjects like Oxidative stress, which are linked to Fisetin, Luteolin, Proinflammatory cytokine and Pharmacology.
His is doing research in Cytochrome P450 and Receptor, both of which are found in Biochemistry. His Cytochrome P450 research includes elements of Nuclear receptor, Constitutive androstane receptor, Regulation of gene expression and Epidermal growth factor receptor. His studies deal with areas such as Intestinal absorption, Isozyme, Androstane and Intestinal epithelium as well as Cell culture.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
THE NUCLEAR ORPHAN RECEPTOR CAR-RETINOID X RECEPTOR HETERODIMER ACTIVATES THE PHENOBARBITAL-RESPONSIVE ENHANCER MODULE OF THE CYP2B GENE
Paavo Honkakoski;Igor Zelko;Tatsuya Sueyoshi;Masahiko Negishi.
Molecular and Cellular Biology (1998)
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene.
Tatsuya Sueyoshi;Takeshi Kawamoto;Igor Zelko;Paavo Honkakoski.
Journal of Biological Chemistry (1999)
Inhibition and induction of human cytochrome P450 enzymes: current status.
Olavi Pelkonen;Miia Turpeinen;Miia Turpeinen;Miia Turpeinen;Jukka Hakkola;Paavo Honkakoski.
Archives of Toxicology (2008)
Regulation of cytochrome P450 (CYP) genes by nuclear receptors
Paavo Honkakoski;Masahiko Negishi.
Biochemical Journal (2000)
Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes.
Marika Ruponen;Seppo Rönkkö;Paavo Honkakoski;Jukka Pelkonen.
Journal of Biological Chemistry (2001)
Drug-activated nuclear receptors CAR and PXR.
Paavo Honkakoski;Tatsuya Sueyoshi;Masahiko Negishi.
Annals of Medicine (2003)
ACTIVATION BY DIVERSE XENOCHEMICALS OF THE 51-BASE PAIR PHENOBARBITAL-RESPONSIVE ENHANCER MODULE IN THE CYP2B10 GENE
Paavo Honkakoski;Rick Moore;Kimberly A. Washburn;Masahiko Negishi.
Molecular Pharmacology (1998)
High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans
Anne-Marie Camus;Olivier Geneste;Paavo Honkakoski;Jean-Claude Béréziat.
Molecular Carcinogenesis (1993)
Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.
Paavo Honkakoski;Masahiko Negishi.
Journal of Biological Chemistry (1997)
Extracellular and intracellular barriers in non-viral gene delivery
Marika Ruponen;Paavo Honkakoski;Seppo Rönkkö;Jukka Pelkonen.
Journal of Controlled Release (2003)
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