What is he best known for?
The fields of study he is best known for:
His main research concerns Pregnane X receptor, Constitutive androstane receptor, Nuclear receptor, Biochemistry and Glucocorticoid receptor.
The concepts of his Pregnane X receptor study are interwoven with issues in Retinoid X receptor alpha, CYP3A4, Receptor, Molecular biology and Promoter.
His Molecular biology study incorporates themes from CYP2B6 and Chromatin immunoprecipitation.
His Constitutive androstane receptor research is multidisciplinary, incorporating perspectives in Estrogen-related receptor gamma and Cell biology.
His Nuclear receptor research is multidisciplinary, relying on both Aryl hydrocarbon receptor, Signal transduction and Pharmacology.
As part of his Internal medicine, Endocrinology and Glucocorticoid and Glucocorticoid receptor studies, Jean-Marc Pascussi is studying Glucocorticoid receptor.
His most cited work include:
- Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. (329 citations)
- The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors (299 citations)
- Expression of CYP3A4, CYP2B6, andCYP2C9 Is Regulated by the Vitamin D Receptor Pathway in Primary Human Hepatocytes (296 citations)
What are the main themes of his work throughout his whole career to date?
Jean-Marc Pascussi mostly deals with Pregnane X receptor, Nuclear receptor, Constitutive androstane receptor, Biochemistry and Internal medicine.
His work carried out in the field of Pregnane X receptor brings together such families of science as CYP3A4, Calcitriol receptor, Receptor, Molecular biology and Pharmacology.
His work deals with themes such as Aryl hydrocarbon receptor, Transactivation, Cytochrome P450, Regulation of gene expression and Glucocorticoid, which intersect with Nuclear receptor.
His Constitutive androstane receptor research includes elements of Retinoid X receptor, Estrogen-related receptor gamma, Signal transduction, Cell biology and Glucocorticoid receptor.
His work on Ligand, Luciferase, Reductase and Cholesterol as part of general Biochemistry research is frequently linked to Hepatocyte, thereby connecting diverse disciplines of science.
His study looks at the relationship between Internal medicine and fields such as Endocrinology, as well as how they intersect with chemical problems.
He most often published in these fields:
- Pregnane X receptor (65.25%)
- Nuclear receptor (51.69%)
- Constitutive androstane receptor (38.14%)
What were the highlights of his more recent work (between 2014-2020)?
- Cancer research (26.27%)
- Cancer stem cell (19.49%)
- Colorectal cancer (20.34%)
In recent papers he was focusing on the following fields of study:
Jean-Marc Pascussi focuses on Cancer research, Cancer stem cell, Colorectal cancer, Pregnane X receptor and Internal medicine.
His studies in Cancer research integrate themes in fields like Cancer recurrence, Cancer and Adjuvant.
His research integrates issues of Cancer cell, Hepatocellular carcinoma, Metastasis and Cellular differentiation in his study of Cancer stem cell.
His Pregnane X receptor research is classified as research in Nuclear receptor.
He interconnects Endocrinology, Oncology and Drug metabolism in the investigation of issues within Internal medicine.
In the subject of general Receptor, his work in Ligand is often linked to Supramolecular chemistry, thereby combining diverse domains of study.
Between 2014 and 2020, his most popular works were:
- Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds (97 citations)
- Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds (97 citations)
- Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds (97 citations)
In his most recent research, the most cited papers focused on:
His scientific interests lie mostly in Cancer research, Cancer stem cell, Metastasis, Colorectal cancer and Cytotoxic T cell.
His Cancer research research incorporates elements of Cell, microRNA, Stem cell and Cell growth.
His Cytotoxic T cell research incorporates Pathology, Cellular differentiation and Ex vivo.
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