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Overview

Dominique Larrey is affiliated with the University of Montpellier in France and has contributed extensively to the field of medicine, with a particular focus on hepatology and related subfields. Their research portfolio includes significant work in epidemiology, pharmacology, surgery, and oncology as they relate to liver diseases.

The researcher's work addresses core topics such as liver disease diagnosis and treatment, hepatitis C virus research, drug-induced hepatotoxicity and protection, lipoproteins and cardiovascular health, hepatitis B virus studies, liver disease and transplantation, and liver diseases and immunity.

Dominique Larrey's recent publications include:

  • Drug-Induced Liver Injury and COVID-19 Infection: The Rules Remain the Same, 2020, Drug Safety
  • Chemotherapy-associated steatohepatitis, 2020, Annals of Hepatology
  • Personalized surveillance for hepatocellular carcinoma in cirrhosis - using machine learning adapted to HCV status, 2020, Journal of Hepatology
  • Combination of fibrates with obeticholic acid is able to normalise biochemical liver tests in patients with difficult-to-treat primary biliary cholangitis, 2021, Alimentary Pharmacology & Therapeutics
  • Long-term safety and efficacy of lomitapide in patients with homozygous familial hypercholesterolemia: Five-year data from the Lomitapide Observational Worldwide Evaluation Registry (LOWER), 2020, Journal of clinical lipidology

Their frequent co-authors reflect a collaborative research environment and include:

  • Stanislas Pol
  • Lucy Meunier
  • Fabrice Carrat
  • Marc Bourlière
  • Victor de Lédinghen

Dominique Larrey publishes regularly in several key journals aligned with their research areas. The main publication venues include:

  • Journal of Hepatology
  • Liver International
  • Journal of clinical lipidology
  • Clinics and Research in Hepatology and Gastroenterology
  • Alimentary Pharmacology & Therapeutics

The overall research impact is shaped by a strong emphasis on liver-related diseases, spanning foundational clinical investigations and advanced applications such as machine learning for hepatocellular carcinoma surveillance adapted to viral hepatitis status. This interdisciplinary approach covers clinical and pharmacological aspects relevant to liver health, reflecting sustained contributions to the understanding and management of liver pathologies.

Best Publications

  • Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

    Vlad Ratziu;Vlad Ratziu;Stephen A. Harrison;Sven Francque;Pierre Bedossa

  • Case definition and phenotype standardization in drug-induced liver injury

    GP Aithal;PB Watkins;RJ Andrade;D Larrey

  • EASL Clinical Practice Guidelines: Drug-induced liver injury

    Raúl J. Andrade;Guruprasad P. Aithal;Einar S. Björnsson;Neil Kaplowitz

  • Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study

    Fabrice Carrat;Hélène Fontaine;Céline Dorival;Mélanie Simony

  • A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis.

    Christophe Corpechot;Olivier Chazouillères;Alexandra Rousseau;Antonia Le Gruyer

  • Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications

    Pierre Nahon;Pierre Nahon;Valérie Bourcier;Richard Layese;Etienne Audureau

  • Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890

    Christophe Hézode;Hélène Fontaine;Céline Dorival;Dominique Larrey

  • A randomized controlled trial of high-dose ursodesoxycholic acid for nonalcoholic steatohepatitis.

    Vlad Ratziu;Victor de Ledinghen;Fréderic Oberti;Philippe Mathurin

  • SCH 503034, a Novel Hepatitis C Virus Protease Inhibitor, Plus Pegylated Interferon α-2b for Genotype 1 Nonresponders

    Christoph Sarrazin;Christoph Sarrazin;Regine Rouzier;Frank Wagner;Nicole Forestier;Nicole Forestier

  • Epidemiology and individual susceptibility to adverse drug reactions affecting the liver.

    Dominique Larrey

  • Ledipasvir-sofosbuvir with or without ribavirin to treat patients with HCV genotype 1 infection and cirrhosis non-responsive to previous protease-inhibitor therapy: a randomised, double-blind, phase 2 trial (SIRIUS)

    Marc Bourlière;Jean Pierre Bronowicki;Victor de Ledinghen;Christophe Hézode

  • Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant.

    Philippe Lettéron;Gilles Labbe;Claude Degott;Alain Berson

  • Effectiveness of Telaprevir or Boceprevir in Treatment-Experienced Patients With HCV Genotype 1 Infection and Cirrhosis

    Christophe Hézode;Helene Fontaine;Celine Dorival;Fabien Zoulim

  • Drug-induced liver diseases

    Dominique Larrey

  • Alcohol relapse after liver transplantation for alcoholic liver disease: does it matter?

    Georges-Philippe Pageaux;Michael Bismuth;Pascal Perney;Valérie Costes

  • Comparison of nine blood tests and transient elastography for liver fibrosis in chronic hepatitis C: The ANRS HCEP-23 study

    Jean-Pierre Zarski;Nathalie Sturm;Jérôme Guechot;Adeline Paris

  • Hepatic Findings in Long-Term Clinical Trials of Ximelagatran

    William M. Lee;Dominique Larrey;Rolf Olsson;James H. Lewis

  • Drug-induced prolonged cholestasis in adults: A histological semiquantitative study demonstrating progressive ductopenia

    Claude Degott;Gérard Feldmann;Dominique Larrey;Anne-Marie Durand-Schneider

  • Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

    Paola Nicoletti;Guruprasad P. Aithal;Einar S. Bjornsson;Raul J. A Andrade

  • Risk factors for hepatic decompensation in patients with HIV/HCV coinfection and liver cirrhosis during interferon-based therapy

    Stefan Mauss;William Valenti;Jean DePamphilis;Frank Duff

Frequent Co-Authors

Stanislas Pol
Stanislas Pol Université Paris Cité
Christophe Hézode
Christophe Hézode Université Paris Cité
Jean-Pierre Bronowicki
Jean-Pierre Bronowicki University Hospital of Nancy
Marc Bourlière
Marc Bourlière Hôpital Saint Joseph
Albert Tran
Albert Tran Inserm : Institut national de la santé et de la recherche médicale
Claude Degott
Claude Degott Beaujon Hospital
Laurent Alric
Laurent Alric Federal University of Toulouse Midi-Pyrénées
Jean-Pierre Benhamou
Jean-Pierre Benhamou Grenoble Alpes University

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