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Medicine

D-Index
104
Citations
48814
World Ranking
6960
National Ranking
3664

Research.com Recognitions

  • 1987 - Member of the National Academy of Medicine (NAM)
  • 1978 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Leslie Z. Benet is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Medicine and Pharmacology, Toxicology and Pharmaceutics, with extensive work in subfields such as Pharmacology, Oncology, Pediatrics, Perinatology and Child Health, Statistics and Probability, and Immunology.

The scientist's work has contributed notably to several research topics, including:

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Statistical Methods in Clinical Trials
  • Biosimilars and Bioanalytical Methods
  • Analytical Chemistry and Chromatography
  • Drug-Induced Hepatotoxicity and Protection

Leslie Z. Benet has published extensively in various scientific journals. Frequent publication venues include:

  • The AAPS Journal
  • Pharmaceutical Research
  • Drug Metabolism and Disposition
  • Clinical Pharmacology & Therapeutics
  • Drug Metabolism and Pharmacokinetics

Selected recent papers illustrate the thematic focus and evolution of their research:

  • "The Critical Role of Passive Permeability in Designing Successful Drugs," 2020, ChemMedChem
  • "Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization," 2021, Journal of Medicinal Chemistry
  • "Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis," 2020, Pharmacology
  • "State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References," 2022, The AAPS Journal
  • "Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination?," 2020, Drug Metabolism and Disposition

The scientist has collaborated regularly with several coauthors, including Jasleen K. Sodhi, Yue Xiang, Shuaibing Liu, Wei Liu, and Suodi Zhai. Notably, collaboration with Jasleen K. Sodhi stands out with a higher number of joint works.

Leslie Z. Benet has received professional recognition by being named a Member of the National Academy of Medicine in 1987 and as a Fellow of the American Association for the Advancement of Science in 1978.

Best Publications

  • Membrane transporters in drug development.

    Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet

  • Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

    Chi-Yuan Wu;Leslie Z. Benet

  • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

    Vincent J. Wacher;Chi‐Yuan Wu;Leslie Z. Benet

  • Clearance concepts in pharmacokinetics

    Malcolm Rowland;Leslie Z. Benet;Garry G. Graham

  • Changes in plasma protein binding have little clinical relevance.

    Leslie Z. Benet;Betty‐Ann Hoener

  • Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

    Kenneth S. Lown;Kenneth S. Lown;Robert R. Mayo;Robert R. Mayo;Alan B. Leichtman;Alan B. Leichtman;Hsiu Ling Hsiao;Hsiu Ling Hsiao

  • BDDCS, the Rule of 5 and drugability.

    Leslie Z. Benet;Chelsea M. Hosey;Oleg Ursu;Tudor I. Oprea

  • The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein.

    Yuanchao Zhang;Leslie Z. Benet

  • BDDCS Applied to Over 900 Drugs

    Leslie Z. Benet;Fabio Broccatelli;Fabio Broccatelli;Tudor I. Oprea;Tudor I. Oprea

  • Gender Effects in Pharmacokinetics and Pharmacodynamics

    Robert Z. Harris;Leslie Z. Benet;Janice B. Schwartz

  • Role of P‐glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics

    Vincent J. Wacher;Jeffrey A. Silverman;Yuanchao Zhang;Leslie Z. Benet

  • Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

    Spahn-Langguth H;Benet Lz

  • PREDICTING DRUG DISPOSITION, ABSORPTION / ELIMINATION / TRANSPORTER INTERPLAY AND THE ROLE OF FOOD ON DRUG ABSORPTION

    Joseph M. Custodio;Chi-Yuan Wu;Leslie Z. Benet

  • The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

    Sarah Shugarts;Leslie Z. Benet

  • Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction.

    Mary F Hebert;John P Roberts;Thomayant Prueksaritanont;Leslie Z Benet

  • Active secretion and enterocytic drug metabolism barriers to drug absorption

    Vincent J. Wacher;Laurent Salphati;Leslie Z. Benet

  • effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.

    Y Y Lau;Y Huang;L Frassetto;L Z Benet

  • Opportunities for Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

    Carl C. Peck;William H. Barr;Leslie Z. Benet;Jerry Collins

  • Mechanisms of clinically relevant drug interactions associated with tacrolimus.

    Uwe Christians;Uwe Christians;Wolfgang Jacobsen;Leslie Z. Benet;Alfonso Lampen

  • Unmasking the Dynamic Interplay between Intestinal P-Glycoprotein and CYP3A4

    Carolyn L. Cummins;Wolfgang Jacobsen;Leslie Z. Benet

Frequent Co-Authors

Uwe Christians
Uwe Christians University of Colorado Anschutz Medical Campus
Gerhard Levy
Gerhard Levy University at Buffalo, State University of New York
Abraham M. Rudolph
Abraham M. Rudolph University of California, San Francisco
Dieter Leibfritz
Dieter Leibfritz University of Bremen
Gordon L. Amidon
Gordon L. Amidon University of Michigan–Ann Arbor
Gerald J. Berry
Gerald J. Berry Stanford University
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco
John P. Roberts
John P. Roberts University of California, San Francisco
Jerry M. Collins
Jerry M. Collins National Institutes of Health
Malcolm Rowland
Malcolm Rowland University of Manchester

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