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Medicine

D-Index
84
Citations
23690
World Ranking
15198
National Ranking
1398

Overview

Malcolm Rowland is affiliated with the University of Manchester in the United Kingdom and operates primarily within the fields of Medicine and Pharmacology, Toxicology and Pharmaceutics. Their body of work broadly covers pharmacogenetics, drug metabolism, and various drug transport and resistance mechanisms.

Recent publications by Malcolm Rowland span several journals and years. Notable papers include:

  • Phase 0/microdosing approaches: time for mainstream application in drug development?, 2020, Nature Reviews Drug Discovery
  • In Defense of Current Concepts and Applications of Clearance in Drug Development and Therapeutics, 2021, Drug Metabolism and Disposition
  • Kirchhoff's Laws and Hepatic Clearance, Well-Stirred Model - Is There Common Ground?, 2023, Drug Metabolism and Disposition
  • Hepatic clearance models and IVIVE predictions, 2022, Clinical Pharmacology & Therapeutics
  • Target Reserve and Turnover Parameters Determine Rightward Shift of Enalaprilat Potency From its Binding Affinity to the Angiotensin Converting Enzyme, 2023, Journal of Pharmaceutical Sciences

Their frequent co-authors include K. Sandy Pang, Tal Burt, Graeme Young, Wooin Lee, and Hiroyuki Kusuhara. This collaboration network reflects a focus on detailed pharmacological research and drug metabolism studies.

Malcolm Rowland's research interests cover specialized topics such as:

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Biosimilars and Bioanalytical Methods
  • Microfluidic and Capillary Electrophoresis Applications
  • Cardiac electrophysiology and arrhythmias
  • Liver Disease Diagnosis and Treatment

Their publication venues also indicate a focus on journals like Drug Metabolism and Disposition, Nature Reviews Drug Discovery, Clinical Pharmacology & Therapeutics, and the Journal of Pharmaceutical Sciences, consistent with their areas of pharmacology and therapeutics research.

Best Publications

  • Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

    Trudy Rodgers;Malcolm Rowland

  • Clearance concepts in pharmacokinetics

    Malcolm Rowland;Leslie Z. Benet;Garry G. Graham

  • Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate‐to‐strong bases

    Trudy Rodgers;David Leahy;Malcolm Rowland

  • Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans.

    Pate D. Thomson;Kenneth L. Melmon;James A. Richardson;Keith Cohn

  • Physiologically-based pharmacokinetics in drug development and regulatory science.

    Malcolm Rowland;Carl Peck;Geoffrey Tucker

  • Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single Compartment

    S. Riegelman;J.C.K. Loo;M. Rowland

  • Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine

    Chi Yuan Wu;Leslie Z. Benet;Mary F. Hebert;Suneel K. Gupta

  • Absorption kinetics of aspirin in man following oral administration of an aqueous solution

    Malcolm Rowland;Sidney Riegelman;Phillip A. Harris;Stephen D. Sholkoff

  • Influence of Route of Administration on Drug Availability

    Malcolm Rowland

  • Bridging the efficacy–effectiveness gap: a regulator's perspective on addressing variability of drug response

    Hans-Georg Eichler;Eric Abadie;Eric Abadie;Alasdair Breckenridge;Bruno Flamion

  • A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations

    Michael S. Roberts;Malcolm Rowland

  • Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion model

    Neal Benowitz;Ralph P. Forsyth;Kenneth L. Melmon;Malcolm Rowland

  • Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.

    Mohamad Shebley;Punam Sandhu;Arian Emami Riedmaier;Masoud Jamei

  • Use of microdosing to predict pharmacokinetics at the therapeutic dose: Experience with 5 drugs

    Graham Lappin;Wilhelm Kuhnz;Roeline Jochemsen;Johannes Kneer

  • Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers.

    C. J. Watson;M. Rowland;G. Warhurst

  • Best Practice in the Use of Physiologically Based Pharmacokinetic Modeling and Simulation to Address Clinical Pharmacology Regulatory Questions

    Ping Zhao;Malcolm Rowland;Malcolm Rowland;Shiew-Mei Huang

  • Physiologic modeling of cyclosporin kinetics in rat and man

    Alberto Bernareggi;Malcolm Rowland

  • Pharmacokinetics of Acetylsalicylic Acid and Salicylic Acid After Intravenous Administration in Man

    Malcolm Rowland;Sidney Riegelman

  • PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

    Patrick Poulin;Rhys D.O. Jones;Hannah M. Jones;Christopher R. Gibson

  • Physiologically Based Pharmacokinetics of Cyclosporine A: Extension to Tissue Distribution Kinetics in Rats and Scale-up to Human

    Ryosei Kawai;Diane Mathew;Chiaki Tanaka;Malcolm Rowland

Frequent Co-Authors

Andrew J. McLachlan
Andrew J. McLachlan University of Sydney
Michael S. Roberts
Michael S. Roberts University of Queensland
Leslie Z. Benet
Leslie Z. Benet University of California, San Francisco
Amin Rostami-Hodjegan
Amin Rostami-Hodjegan University of Manchester
J. Brian Houston
J. Brian Houston University of Manchester
Lawrence J. Lesko
Lawrence J. Lesko University of Florida
Hubert G. M. Leufkens
Hubert G. M. Leufkens Utrecht University
Gordon L. Amidon
Gordon L. Amidon University of Michigan–Ann Arbor
Kenneth T. Douglas
Kenneth T. Douglas University of Manchester
Nancy J. Rothwell
Nancy J. Rothwell University of Manchester

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