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Hubert G. M. Leufkens

Hubert G. M. Leufkens

D-Index & Metrics

Medicine

D-Index
95
Citations
39458
World Ranking
9952
National Ranking
391

Overview

Hubert G. M. Leufkens is affiliated with Utrecht University in the Netherlands. Their research primarily spans the fields of Medicine as well as Economics, Econometrics, and Finance. This multidisciplinary approach is reflected in a substantial body of work across related subfields, including Economics and Econometrics, Pediatrics, Perinatology and Child Health, Physiology, Public Health, Environmental and Occupational Health, and Pulmonary and Respiratory Medicine.

The scientist's work encompasses several main research topics such as Health Systems, Economic Evaluations, Quality of Life; Pharmaceutical Economics and Policy; Pharmaceutical Studies and Practices; Biomedical Ethics and Regulation; Biosimilars and Bioanalytical Methods; Pharmaceutical Practices and Patient Outcomes; and CAR-T Cell Therapy Research.

Frequent publication venues highlight a focus on both clinical and policy-oriented journals, including:

  • Drug Discovery Today
  • Value in Health
  • Frontiers in Pharmacology
  • International Journal of Technology Assessment in Health Care
  • Journal of Pharmaceutical Policy and Practice

Common collaborators appear in the data as well, indicating a network of research partnerships. Frequent co-authors include Aukje K. Mantel-Teeuwisse, Wim Goettsch, Helga Gardarsdóttir, Rick A. Vreman, and Jarno Hoekman.

A selection of recent research articles illustrates the scope and focus of their work:

  • Decision Making Under Uncertainty: Comparing Regulatory and Health Technology Assessment Reviews of Medicines in the United States and Europe, 2020, Clinical Pharmacology & Therapeutics
  • What does cell therapy manufacturing cost? A framework and methodology to facilitate academic and other small-scale cell therapy manufacturing costings, 2020, Cytotherapy
  • Differences in Health Technology Assessment Recommendations Among European Jurisdictions: The Role of Practice Variations, 2020, Value in Health
  • The impact of FDA and EMA regulatory decision-making process on the access to CFTR modulators for the treatment of cystic fibrosis, 2022, Orphanet Journal of Rare Diseases
  • Drug Repurposing for Rare Diseases: A Role for Academia, 2021, Frontiers in Pharmacology

The publications demonstrate an interest in regulatory decision-making, health technology assessment, economics of cell therapy manufacturing, and rare disease drug repurposing, reflecting a blend of health policy, economic evaluation, and pharmaceutical regulation.

Best Publications

  • Use of oral corticosteroids and risk of fractures.

    T. P. Van Staa;T. P. Van Staa;H. G. M. Leufkens;L. Abenhaim;L. Abenhaim;B. Zhang

  • The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis.

    T. P. van Staa;H. G. M. Leufkens;C. Cooper

  • Epidemiology of fractures in England and Wales

    T.P van Staa;E.M Dennison;H.G.M Leufkens;C Cooper

  • A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions.

    Eugène P van Puijenbroek;Andrew Bate;Andrew Bate;Hubert G M Leufkens;Marie Lindquist

  • Oral corticosteroids and fracture risk: relationship to daily and cumulative doses

    T. P. van Staa;H. G. M. Leufkens;L. Abenhaim;B. Zhang

  • Dronedarone in High-Risk Permanent Atrial Fibrillation

    Amany N. Elgazayerly;Pieter A. de Graeff;Hubert G. Leufkens

  • Adverse drug events in hospitalized patients: A comparison of doctors, nurses and patients as sources of reports

    P. M. L. A. van den Bemt;A. C. G. Egberts;A. W. Lenderink;J. M. Verzijl

  • Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis

    T. P. Van Staa;P. Geusens;J. W. J. Bijlsma;H. G. M. Leufkens

  • Use of oral corticosteroids in the United Kingdom

    T.P. van Staa;H.G.M. Leufkens;L. Abenhaim;B. Begaud

  • Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case–control study

    P C Souverein;A Berard;T P Van Staa;C Cooper

  • Psychoactive substance use and the risk of motor vehicle accidents

    K.L.L. Movig;M.P.M. Mathijssen;P.H.A. Nagel;T. van Egmond

  • Beliefs about medicines predict refill adherence to inhaled corticosteroids.

    Tanja T. Menckeberg;Marcel L. Bouvy;Madelon Bracke;Ad A. Kaptein

  • NSAIDs Associated With Increased Risk of Congestive Heart Failure in Elderly Patients Taking Diuretics

    Eibert R. Heerdink;Hubert G. Leufkens;Ron M. C. Herings;Jan P. Ottervanger

  • Does a fracture at one site predict later fractures at other sites? A British cohort study.

    T. P. van Staa;H. G. M. Leufkens;C. Cooper

  • Incidence and natural history of Paget's disease of bone in England and Wales.

    T. P. Van Staa;P. Selby;H. G. M. Leufkens;K. Lyles;K. Lyles

  • Hospitalisations and emergency department visits due to drug–drug interactions: a literature review

    Matthijs L Becker;Marjon Kallewaard;Peter W J Caspers;Loes E Visser

  • Bridging the efficacy–effectiveness gap: a regulator's perspective on addressing variability of drug response

    Hans-Georg Eichler;Eric Abadie;Eric Abadie;Alasdair Breckenridge;Bruno Flamion

  • 5-Aminosalicylate use and colorectal cancer risk in inflammatory bowel disease: a large epidemiological study

    T P van Staa;T Card;R F Logan;H G M Leufkens

  • Safety-Related Regulatory Actions for Biologicals Approved in the United States and the European Union

    Thijs J. Giezen;Aukje K. Mantel-Teeuwisse;Sabine M. J. M. Straus;Huub Schellekens

  • Association of Risk of Abnormal Bleeding With Degree of Serotonin Reuptake Inhibition by Antidepressants

    Welmoed E. E. Meijer;Eibert R. Heerdink;Willem A. Nolen;Ron M. C. Herings

Frequent Co-Authors

Antoine C. G. Egberts
Antoine C. G. Egberts Utrecht University
Cyrus Cooper
Cyrus Cooper University of Southampton
Arno W. Hoes
Arno W. Hoes Utrecht University
Willem A. Nolen
Willem A. Nolen University Medical Center Groningen
Huub Schellekens
Huub Schellekens Utrecht University
Peter Vestergaard
Peter Vestergaard Aalborg University
Diederick E. Grobbee
Diederick E. Grobbee Utrecht University
Ronald P. Stolk
Ronald P. Stolk University Medical Center Groningen
Bruno H. Stricker
Bruno H. Stricker Erasmus University Rotterdam
Hans-Georg Eichler
Hans-Georg Eichler European Medicines Agency

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